The landscape of tumor cell states and spatial organization in
H3-K27M mutant diffuse midline glioma across age and location

J 2022

The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location

LIU, I., L. JIANG, E. R. SAMUELSSON, S. MARCO SALAS, A. BECK et. al.

Základní údaje

Originální název

The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location

Autoři

LIU, I. (garant), L. JIANG, E. R. SAMUELSSON, S. MARCO SALAS, A. BECK, O. A. HACK, D. JEONG, M. L. SHAW, B. ENGLINGER, J. LABELLE, H. M. MIRE, S. MADLENER, L. MAYR, M. A. QUEZADA, M. TRISSAL, E. PANDITHARATNA, K. J. ERNST, J. VOGELZANG, T. A. GATESMAN, M. E. HALBERT, Hana PÁLOVÁ (203 Česká republika, domácí), Petra POKORNÁ (203 Česká republika, domácí), Jaroslav ŠTĚRBA (203 Česká republika, domácí), Ondřej SLABÝ (203 Česká republika, domácí), R. GEYEREGGER, A. DIAZ, I. J. FINDLAY, M. D. DUN, A. RESNICK, M. L SUVÀ., D. T. W. JONES, S. AGNIHOTRI, J. SVEDLUND, C. KOSCHMANN, C. HABERLER, T. CZECH, I. SLAVC, J. A. COTTER, K. L. LIGON, S. ALEXANDRESCU, W. K. A. YUNG, I. ARRILLAGA-ROMANY, J. GOJO, M. MONJE, M. NILSSON a M. G. FILBIN

Vydání

Nature Genetics, BERLIN, NATURE PORTFOLIO, 2022, 1061-4036

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 30.800

Kód RIV

RIV/00216224:14110/22:00127554

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/s41588-022-01236-3

UT WoS

000920296200009

Klíčová slova anglicky

Ageing; Cancer microenvironment; CNS cancer; Transcriptomics

Štítky

14110321, 14110513, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 3. 2023 09:17, Mgr. Tereza Miškechová

Anotace

V originále

Histone 3 lysine27-to-methionine (H3-K27M) mutations most frequently occur in diffuse midline gliomas (DMGs) of the childhood pons but are also increasingly recognized in adults. Their potential heterogeneity at different ages and midline locations is vastly understudied. Here, through dissecting the single-cell transcriptomic, epigenomic and spatial architectures of a comprehensive cohort of patient H3-K27M DMGs, we delineate how age and anatomical location shape glioma cell-intrinsic and -extrinsic features in light of the shared driver mutation. We show that stem-like oligodendroglial precursor-like cells, present across all clinico-anatomical groups, display varying levels of maturation dependent on location. We reveal a previously underappreciated relationship between mesenchymal cancer cell states and age, linked to age-dependent differences in the immune microenvironment. Further, we resolve the spatial organization of H3-K27M DMG cell populations and identify a mitotic oligodendroglial-lineage niche. Collectively, our study provides a powerful framework for rational modeling and therapeutic interventions.

Návaznosti

LX22NPO5102, projekt VaV

Název: Národní ústav pro výzkum rakoviny (Akronym: NÚVR)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro výzkum rakoviny, 5.1 EXCELES

MUNI/A/1427/2021, interní kód MU

Název: Personalizovaná léčba v dětské onkologii: na cestě k „liquid dynamic medicine“ a „N-of-1 clinical trials“

Investor: Masarykova univerzita, Personalizovaná léčba v dětské onkologii: na cestě k „liquid dynamic medicine“ a „N-of-1 clinical trials“

NU20-03-00240, projekt VaV

Název: Celoexomové sekvenování, sekvenování genomu s nízkým pokrytím a transkriptomu pro účely precizní onkologie u dětských pacientů s vysoce rizikovými a relabovanými solidními nádory

Investor: Ministerstvo zdravotnictví ČR, Celoexomové sekvenování, sekvenování genomu s nízkým pokrytím a transkriptomu pro účely precizní onkologie u dětských pacientů s vysoce rizikovými a relabovanými solidními nádory, Podprogram 1 - standardní

Přiložené soubory

The_landscape_of_tumor_cell_states_and_spatial_organization_in_H3-K27M_mutant_diffuse_midline_glioma_across_age_and_locatio.pdf

Vyhledat podobné dokumenty

Citovat

LIU, I., L. JIANG, E. R. SAMUELSSON, S. MARCO SALAS, A. BECK, O. A. HACK, D. JEONG, M. L. SHAW, B. ENGLINGER, J. LABELLE, H. M. MIRE, S. MADLENER, L. MAYR, M. A. QUEZADA, M. TRISSAL, E. PANDITHARATNA, K. J. ERNST, J. VOGELZANG, T. A. GATESMAN, M. E. HALBERT, Hana PÁLOVÁ, Petra POKORNÁ, Jaroslav ŠTĚRBA, Ondřej SLABÝ, R. GEYEREGGER, A. DIAZ, I. J. FINDLAY, M. D. DUN, A. RESNICK, M. L SUVÀ., D. T. W. JONES, S. AGNIHOTRI, J. SVEDLUND, C. KOSCHMANN, C. HABERLER, T. CZECH, I. SLAVC, J. A. COTTER, K. L. LIGON, S. ALEXANDRESCU, W. K. A. YUNG, I. ARRILLAGA-ROMANY, J. GOJO, M. MONJE, M. NILSSON a M. G. FILBIN. The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location. Nature Genetics. BERLIN: NATURE PORTFOLIO, 2022, roč. 54, December 2022, s. 1881-1894. ISSN 1061-4036. Dostupné z: https://dx.doi.org/10.1038/s41588-022-01236-3.

@article{2241228,
   author = {Liu, I. and Jiang, L. and Samuelsson, E. R. and Marco Salas, S. and Beck, A. and Hack, O. A. and Jeong, D. and Shaw, M. L. and Englinger, B. and LaBelle, J. and Mire, H. M. and Madlener, S. and Mayr, L. and Quezada, M. A. and Trissal, M. and Panditharatna, E. and Ernst, K. J. and Vogelzang, J. and Gatesman, T. A. and Halbert, M. E. and Pálová, Hana and Pokorná, Petra and Štěrba, Jaroslav and Slabý, Ondřej and Geyeregger, R. and Diaz, A. and Findlay, I. J. and Dun, M. D. and Resnick, A. and Suvà., M. L and Jones, D. T. W. and Agnihotri, S. and Svedlund, J. and Koschmann, C. and Haberler, C. and Czech, T. and Slavc, I. and Cotter, J. A. and Ligon, K. L. and Alexandrescu, S. and Yung, W. K. A. and ArrillagaandRomany, I. and Gojo, J. and Monje, M. and Nilsson, M. and Filbin, M. G.},
   article_location = {BERLIN},
   article_number = {December 2022},
   doi = {http://dx.doi.org/10.1038/s41588-022-01236-3},
   keywords = {Ageing; Cancer microenvironment; CNS cancer; Transcriptomics},
   language = {eng},
   issn = {1061-4036},
   journal = {Nature Genetics},
   title = {The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location},
   url = {https://www.nature.com/articles/s41588-022-01236-3},
   volume = {54},
   year = {2022}
}

TY  - JOUR
ID  - 2241228
AU  - Liu, I. - Jiang, L. - Samuelsson, E. R. - Marco Salas, S. - Beck, A. - Hack, O. A. - Jeong, D. - Shaw, M. L. - Englinger, B. - LaBelle, J. - Mire, H. M. - Madlener, S. - Mayr, L. - Quezada, M. A. - Trissal, M. - Panditharatna, E. - Ernst, K. J. - Vogelzang, J. - Gatesman, T. A. - Halbert, M. E. - Pálová, Hana - Pokorná, Petra - Štěrba, Jaroslav - Slabý, Ondřej - Geyeregger, R. - Diaz, A. - Findlay, I. J. - Dun, M. D. - Resnick, A. - Suvà., M. L - Jones, D. T. W. - Agnihotri, S. - Svedlund, J. - Koschmann, C. - Haberler, C. - Czech, T. - Slavc, I. - Cotter, J. A. - Ligon, K. L. - Alexandrescu, S. - Yung, W. K. A. - Arrillaga-Romany, I. - Gojo, J. - Monje, M. - Nilsson, M. - Filbin, M. G.
PY  - 2022
TI  - The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location
JF  - Nature Genetics
VL  - 54
IS  - December 2022
SP  - 1881-1894
EP  - 1881-1894
PB  - NATURE PORTFOLIO
SN  - 10614036
KW  - Ageing
KW  - Cancer microenvironment
KW  - CNS cancer
KW  - Transcriptomics
UR  - https://www.nature.com/articles/s41588-022-01236-3
N2  - Histone 3 lysine27-to-methionine (H3-K27M) mutations most frequently occur in diffuse midline gliomas (DMGs) of the childhood pons but are also increasingly recognized in adults. Their potential heterogeneity at different ages and midline locations is vastly understudied. Here, through dissecting the single-cell transcriptomic, epigenomic and spatial architectures of a comprehensive cohort of patient H3-K27M DMGs, we delineate how age and anatomical location shape glioma cell-intrinsic and -extrinsic features in light of the shared driver mutation. We show that stem-like oligodendroglial precursor-like cells, present across all clinico-anatomical groups, display varying levels of maturation dependent on location. We reveal a previously underappreciated relationship between mesenchymal cancer cell states and age, linked to age-dependent differences in the immune microenvironment. Further, we resolve the spatial organization of H3-K27M DMG cell populations and identify a mitotic oligodendroglial-lineage niche. Collectively, our study provides a powerful framework for rational modeling and therapeutic interventions.
ER  -

LIU, I., L. JIANG, E. R. SAMUELSSON, S. MARCO SALAS, A. BECK, O. A. HACK, D. JEONG, M. L. SHAW, B. ENGLINGER, J. LABELLE, H. M. MIRE, S. MADLENER, L. MAYR, M. A. QUEZADA, M. TRISSAL, E. PANDITHARATNA, K. J. ERNST, J. VOGELZANG, T. A. GATESMAN, M. E. HALBERT, Hana PÁLOVÁ, Petra POKORNÁ, Jaroslav ŠTĚRBA, Ondřej SLABÝ, R. GEYEREGGER, A. DIAZ, I. J. FINDLAY, M. D. DUN, A. RESNICK, M. L SUVÀ., D. T. W. JONES, S. AGNIHOTRI, J. SVEDLUND, C. KOSCHMANN, C. HABERLER, T. CZECH, I. SLAVC, J. A. COTTER, K. L. LIGON, S. ALEXANDRESCU, W. K. A. YUNG, I. ARRILLAGA-ROMANY, J. GOJO, M. MONJE, M. NILSSON a M. G. FILBIN. The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location. \textit{Nature Genetics}. BERLIN: NATURE PORTFOLIO, 2022, roč.~54, December 2022, s.~1881-1894. ISSN~1061-4036. Dostupné z: https://dx.doi.org/10.1038/s41588-022-01236-3.

Podrobný výpis o publikaci