Purification of human telomerase TEN domain and its interaction
partner TPP1

D 2018

Purification of human telomerase TEN domain and its interaction partner TPP1

VEVERKA, Pavel, Martin STOJASPAL, Tomáš JANOVIČ a Ctirad HOFR

Základní údaje

Originální název

Purification of human telomerase TEN domain and its interaction partner TPP1

Autoři

VEVERKA, Pavel, Martin STOJASPAL, Tomáš JANOVIČ a Ctirad HOFR

Vydání

Brno, 15 th International Interdisciplinary Meeting on Bioanalysis, od s. 210-215, 6 s. 2018

Nakladatel

Institute of Analytical Chemistry of the CAS, v. v. i., Brno, Czech Republic

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

elektronická verze "online"

Odkazy

URL

Organizační jednotka

Středoevropský technologický institut

ISBN

978-80-904959-7-5

Klíčová slova anglicky

TELOMERASE; TPP1; SHELTERIN

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 1. 2023 15:57, Mgr. Pavel Veverka, Ph.D.

Anotace

V originále

The telomerase adds telomeric repeats to chromosome ends to act against telomere shortening. Telomerase activation contributes to the immortality of cancer cells. Therefore, telomerase inhibition is an attractive target for cancer therapy. In this study we show initial results of preparation of recombinant construct of TEN domain from human telomerase and human protein TPP1 from shelterin complex, which is responsible for telomerase recruitment to telomeres and promotion of an effective DNA synthesis.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

VEVERKA, Pavel, Martin STOJASPAL, Tomáš JANOVIČ a Ctirad HOFR. Purification of human telomerase TEN domain and its interaction partner TPP1. Online. In František Foret, Jana Křenková, Iveta Drobníková, Karel Klepárník, Jan Přikryl. 15 th International Interdisciplinary Meeting on Bioanalysis. Brno: Institute of Analytical Chemistry of the CAS, v. v. i., Brno, Czech Republic, 2018, s. 210-215. ISBN 978-80-904959-7-5.

@inproceedings{2242998,
   author = {Veverka, Pavel and Stojaspal, Martin and Janovič, Tomáš and Hofr, Ctirad},
   address = {Brno},
   booktitle = {15 th International Interdisciplinary Meeting on Bioanalysis},
   editor = {František Foret, Jana Křenková, Iveta Drobníková, Karel Klepárník, Jan Přikryl},
   keywords = {TELOMERASE; TPP1; SHELTERIN},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {Brno},
   isbn = {978-80-904959-7-5},
   pages = {210-215},
   publisher = {Institute of Analytical Chemistry of the CAS, v. v. i., Brno, Czech Republic},
   title = {Purification of human telomerase TEN domain and its interaction partner TPP1},
   url = {https://www.ce-ce.org/},
   year = {2018}
}

TY  - JOUR
ID  - 2242998
AU  - Veverka, Pavel - Stojaspal, Martin - Janovič, Tomáš - Hofr, Ctirad
PY  - 2018
TI  - Purification of human telomerase TEN domain and its interaction partner TPP1
PB  - Institute of Analytical Chemistry of the CAS, v. v. i., Brno, Czech Republic
CY  - Brno
SN  - 9788090495975
KW  - TELOMERASE
KW  - TPP1
KW  - SHELTERIN
UR  - https://www.ce-ce.org/
N2  - The telomerase adds telomeric repeats to chromosome ends to act against telomere shortening. Telomerase activation contributes to the immortality of cancer cells. Therefore, telomerase inhibition is an attractive target for cancer therapy. In this study we show initial results of preparation of recombinant construct of TEN domain from human telomerase and human protein TPP1 from shelterin complex, which is responsible for telomerase recruitment to telomeres and promotion of an effective DNA synthesis.
ER  -

VEVERKA, Pavel, Martin STOJASPAL, Tomáš JANOVIČ a Ctirad HOFR. Purification of human telomerase TEN domain and its interaction partner TPP1. Online. In František Foret, Jana Křenková, Iveta Drobníková, Karel Klepárník, Jan Přikryl. \textit{15 th International Interdisciplinary Meeting on Bioanalysis}. Brno: Institute of Analytical Chemistry of the CAS, v. v. i., Brno, Czech Republic, 2018, s.~210-215. ISBN~978-80-904959-7-5.

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