2022
Dental Stem Cells: Developmental Aspects
KŘIVÁNEK, Jan a Kaj FRIEDZákladní údaje
Originální název
Dental Stem Cells: Developmental Aspects
Autoři
KŘIVÁNEK, Jan a Kaj FRIED
Vydání
1st Edition. Berlin, Germany, Cell-to-Cell Communication: Cell-Atlas – Visual Biology in Oral Medicine, od s. 55-64, 10 s. Cell-to-Cell Communication, Volume 7, 2022
Nakladatel
Quintessence Publishing Deutschland
Další údaje
Jazyk
angličtina
Typ výsledku
Kapitola resp. kapitoly v odborné knize
Obor
10601 Cell biology
Stát vydavatele
Německo
Utajení
není předmětem státního či obchodního tajemství
Forma vydání
tištěná verze "print"
Odkazy
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14110/22:00127699
Organizační jednotka
Lékařská fakulta
ISBN
978-1-78698-107-3
Klíčová slova anglicky
dental stem cells
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 15. 3. 2023 13:23, Mgr. Tereza Miškechová
Anotace
V originále
Teeth in mammals develop through an interaction between cells of the ectoderm of the first pharyngeal arch in the fetus and neural crest–derived ectomesenchyme. After initiation, this process continues throughout human fetal life and is eventually finalized before adulthood, when progenitor cells vanish. The major types of basic cells involved have been identified for quite some time. However, not until recently has some light been shed on the stem cell heterogeneity in these populations. This heterogeneity reflects the mechanisms of tooth growth and pertains, among other things, to clonal development and to the identities of rare and transient cell types. Histologic identification cannot be made using pure morphologic criteria but requires specific molecular in situ protein or messenger RNA (mRNA) detection. Much of what we know regarding dental stem cells (first mentioned by E. Haeckel, 1868) derives from experimental studies with a focus on the self-renewing rodent incisor. Ample evidence indicates that this is a reasonable model for studies of tooth development in humans. However, human-specific patterns of cellular organization are clearly discernible, with subpopulations that probably contribute to human tooth development, homeostasis, and progression of disease in unique ways.