Polymorphism Rs2421943 of the Insulin-Degrading Enzyme Gene and
the Risk of Late-Onset Alzheimer's Disease

J 2022

Polymorphism Rs2421943 of the Insulin-Degrading Enzyme Gene and the Risk of Late-Onset Alzheimer's Disease

ŠERÝ, Omar; Tomáš ZEMAN; Alice HÁLOVÁ; Vladimír JANOUT; Jana JANOUTOVÁ et. al.

Základní údaje

Originální název

Polymorphism Rs2421943 of the Insulin-Degrading Enzyme Gene and the Risk of Late-Onset Alzheimer's Disease

Autoři

ŠERÝ, Omar (203 Česká republika, garant, domácí); Tomáš ZEMAN (203 Česká republika, domácí); Alice HÁLOVÁ (203 Česká republika, domácí); Vladimír JANOUT (203 Česká republika); Jana JANOUTOVÁ (203 Česká republika); Jan LOCHMAN (203 Česká republika, domácí) a Vladimír Josef BALCAR (36 Austrálie)

Vydání

Current Alzheimer Research, Bentham Science Publishers, 2022, 1567-2050

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené arabské emiráty

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.100

Kód RIV

RIV/00216224:14310/22:00127713

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.2174/1567205019666220302120950

UT WoS

000836179200006

EID Scopus

2-s2.0-85128634714

Klíčová slova anglicky

Alzheimer's disease; mild cognitive impairment; insulin-degrading enzyme; type-2 diabetes mellitus; amyloid-beta peptide; single nucleotide polymorphisms

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 3. 2023 09:27, prof. RNDr. Omar Šerý, Ph.D.

Anotace

V originále

Background: Insulin-degrading enzyme (IDE) is a widely distributed Zn2+-binding metalloprotease that cleaves multiple short and medium-sized peptides prone to form β-structures. These include insulin and amyloid-β peptides. Accumulation and fibrillation of amyloid-β peptides leading to the formation of amyloid plaques is a characteristic sign of Alzheimer’s disease (AD) pathology. Objective: The study investigated the rs2421943 single nucleotide polymorphism (SNP) of the IDE gene as a risk factor for MCI (mild cognitive impairment) and AD. Methods: Two independent groups of 1670 patients and controls were included. The AD group consisted of 595 patients and 400 controls; the MCI group involved 135 patients and 540 matched controls. PCR and restriction fragment length analysis were used to analyze the rs2421943 polymorphism. Using the miRBase and RNA22 prediction tools in silico indicated that the rs2421943 polymorphism is a potential target for a specific miRNA (hsa-miR-7110-5p). Results: AG and GG genotypes of rs2421943 significantly increased the risk of AD, and the AG genotype increased the risk of MCI. It seems the G allele both increases the risk of AD and accelerates the transition through the MCI phase. In silico study revealed that rs2421943 is inside the sequence binding miRNA hsa-miR-7110-5p. The polymorphism could affect the rate of IDE pre-RNA (heterogeneous nuclear RNA, hnRNA) processing, resulting in slower translation, lower levels of IDE, deficient removal of amyloid-β fragments, and greater risk of and/or accelerated progression of AD. Conclusion: GG and AG genotypes of the single nucleotide polymorphism rs2421943 of insulindegrading enzyme gene increase the risk of AD and MCI.

Citovat

ŠERÝ, Omar; Tomáš ZEMAN; Alice HÁLOVÁ; Vladimír JANOUT; Jana JANOUTOVÁ; Jan LOCHMAN a Vladimír Josef BALCAR. Polymorphism Rs2421943 of the Insulin-Degrading Enzyme Gene and the Risk of Late-Onset Alzheimer's Disease. Current Alzheimer Research. Bentham Science Publishers, 2022, roč. 19, č. 3, s. 236-245. ISSN 1567-2050. Dostupné z: https://dx.doi.org/10.2174/1567205019666220302120950.

@article{2243704,
   author = {Šerý, Omar and Zeman, Tomáš and Hálová, Alice and Janout, Vladimír and Janoutová, Jana and Lochman, Jan and Balcar, Vladimír Josef},
   article_number = {3},
   doi = {http://dx.doi.org/10.2174/1567205019666220302120950},
   keywords = {Alzheimer's disease; mild cognitive impairment; insulin-degrading enzyme; type-2 diabetes mellitus; amyloid-beta peptide; single nucleotide polymorphisms},
   language = {eng},
   issn = {1567-2050},
   journal = {Current Alzheimer Research},
   title = {Polymorphism Rs2421943 of the Insulin-Degrading Enzyme Gene and the Risk of Late-Onset Alzheimer's Disease},
   url = {https://www.eurekaselect.com/article/121244},
   volume = {19},
   year = {2022}
}

TY  - JOUR
ID  - 2243704
AU  - Šerý, Omar - Zeman, Tomáš - Hálová, Alice - Janout, Vladimír - Janoutová, Jana - Lochman, Jan - Balcar, Vladimír Josef
PY  - 2022
TI  - Polymorphism Rs2421943 of the Insulin-Degrading Enzyme Gene and the Risk of Late-Onset Alzheimer's Disease
JF  - Current Alzheimer Research
VL  - 19
IS  - 3
SP  - 236-245
EP  - 236-245
PB  - Bentham Science Publishers
SN  - 15672050
KW  - Alzheimer's disease
KW  - mild cognitive impairment
KW  - insulin-degrading enzyme
KW  - type-2 diabetes mellitus
KW  - amyloid-beta peptide
KW  - single nucleotide polymorphisms
UR  - https://www.eurekaselect.com/article/121244
N2  - Background: Insulin-degrading enzyme (IDE) is a widely distributed Zn2+-binding metalloprotease that cleaves multiple short and medium-sized peptides prone to form β-structures. These include insulin and amyloid-β peptides. Accumulation and fibrillation of amyloid-β peptides leading to the formation of amyloid plaques is a characteristic sign of Alzheimer’s disease (AD) pathology. Objective: The study investigated the rs2421943 single nucleotide polymorphism (SNP) of the IDE gene as a risk factor for MCI (mild cognitive impairment) and AD. Methods: Two independent groups of 1670 patients and controls were included. The AD group consisted of 595 patients and 400 controls; the MCI group involved 135 patients and 540 matched controls. PCR and restriction fragment length analysis were used to analyze the rs2421943 polymorphism. Using the miRBase and RNA22 prediction tools in silico indicated that the rs2421943 polymorphism is a potential target for a specific miRNA (hsa-miR-7110-5p). Results: AG and GG genotypes of rs2421943 significantly increased the risk of AD, and the AG genotype increased the risk of MCI. It seems the G allele both increases the risk of AD and accelerates the transition through the MCI phase. In silico study revealed that rs2421943 is inside the sequence binding miRNA hsa-miR-7110-5p. The polymorphism could affect the rate of IDE pre-RNA (heterogeneous nuclear RNA, hnRNA) processing, resulting in slower translation, lower levels of IDE, deficient removal of amyloid-β fragments, and greater risk of and/or accelerated progression of AD. Conclusion: GG and AG genotypes of the single nucleotide polymorphism rs2421943 of insulindegrading enzyme gene increase the risk of AD and MCI.
ER  -

ŠERÝ, Omar; Tomáš ZEMAN; Alice HÁLOVÁ; Vladimír JANOUT; Jana JANOUTOVÁ; Jan LOCHMAN a Vladimír Josef BALCAR. Polymorphism Rs2421943 of the Insulin-Degrading Enzyme Gene and the Risk of Late-Onset Alzheimer's Disease. \textit{Current Alzheimer Research}. Bentham Science Publishers, 2022, roč.~19, č.~3, s.~236-245. ISSN~1567-2050. Dostupné z: https://dx.doi.org/10.2174/1567205019666220302120950.

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