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@proceedings{2244059,
author = {Škovranová, Gabriela and Čulenová, Marie and Molčanová, Lenka and Treml, Jakub and Alperth, Fabian and Bucar, Franz and Sychrová, Alice},
booktitle = {Natural Products in Drug Discovery and Development – Advances and Perspectives: PSE Meeting September 19–22, 2022, Iasi, Romania},
keywords = {antimicrobial activity; membrane disruption; mycobacterium; prenylated flavonoids},
language = {eng},
note = {PSE Meeting 2022, 19-22.9.2022 Iasi, Romania},
title = {Prenylated flavonoids combating mycobacteria},
url = {https://psemeetingiasi2022.eu/abstracts-book/},
year = {2022}
}
TY - CONF
ID - 2244059
AU - Škovranová, Gabriela - Čulenová, Marie - Molčanová, Lenka - Treml, Jakub - Alperth, Fabian - Bucar, Franz - Sychrová, Alice
PY - 2022
TI - Prenylated flavonoids combating mycobacteria
N1 - PSE Meeting 2022, 19-22.9.2022 Iasi, Romania
KW - antimicrobial activity
KW - membrane disruption
KW - mycobacterium
KW - prenylated flavonoids
UR - https://psemeetingiasi2022.eu/abstracts-book/
N2 - Globally, tuberculosis is one of the primary causes of death. Resistant strains of Mycobacterium tuberculosis as well as other strains of mycobacteria are prompting the search for new drugs and solutions. Twelve prenylated compounds were tested against mycobacterial strains, and the microdilution method revealed a significant antibacterial effect with minimal inhibitory concentrations ranging from 2-16 µg/mL. Membrane damage and permeability disruption is one of the mechanisms of action by which prenylated flavonoids exerted ≤40% effect. The effect of the compounds on the viability of THP-1 cells differentiated into macrophages demonstrated their toxicity with respect to the concentrations used. However, prenylated phenolics represent potential model structures for the development of new antituberculosis drugs.
ER -
ŠKOVRANOVÁ, Gabriela, Marie ČULENOVÁ, Lenka MOLČANOVÁ, Jakub TREML, Fabian ALPERTH, Franz BUCAR a Alice SYCHROVÁ. Prenylated flavonoids combating mycobacteria. In \textit{Natural Products in Drug Discovery and Development – Advances and Perspectives: PSE Meeting September 19–22, 2022, Iasi, Romania}. 2022.
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