White matter alterations in MR-negative temporal and frontal
lobe epilepsy using fixel-based analysis

J 2023

White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis

BARTOŇOVÁ, Michaela, Jacques-Donald TOURNIER, Marek BARTOŇ, Pavel ŘÍHA, Lubomír VOJTÍŠEK et. al.

Základní údaje

Originální název

White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis

Autoři

BARTOŇOVÁ, Michaela (703 Slovensko, domácí), Jacques-Donald TOURNIER (826 Velká Británie a Severní Irsko), Marek BARTOŇ (203 Česká republika, domácí), Pavel ŘÍHA (203 Česká republika, domácí), Lubomír VOJTÍŠEK (203 Česká republika, domácí), Radek MAREČEK (203 Česká republika, domácí), Irena DOLEŽALOVÁ (203 Česká republika, domácí) a Ivan REKTOR (203 Česká republika, garant, domácí)

Vydání

Scientific Reports, Berlin, NATURE PORTFOLIO, 2023, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.600 v roce 2022

Kód RIV

RIV/00216224:14740/23:00130158

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1038/s41598-022-27233-4

UT WoS

000907164800057

Klíčová slova anglicky

Focal Epilepsy; Temporal Lobe Epilepsy (TLE); Frontal Lobe Epilepsy (FLE); MR-negative; Fixel-Based Analysis (FBA); Fibre Density; Fibre Cross-section

Štítky

14110127, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 10. 2024 10:07, Mgr. Adéla Pešková

Anotace

V originále

This study focuses on white matter alterations in pharmacoresistant epilepsy patients with no visible lesions in the temporal and frontal lobes on clinical MRI (i.e. MR-negative) with lesions confirmed by resective surgery. The aim of the study was to extend the knowledge about group-specific neuropathology in MR-negative epilepsy. We used the fixel-based analysis (FBA) that overcomes the limitations of traditional diffusion tensor image analysis, mainly within-voxel averaging of multiple crossing fibres. Group-wise comparisons of fixel parameters between healthy controls (N = 100) and: (1) frontal lobe epilepsy (FLE) patients (N = 9); (2) temporal lobe epilepsy (TLE) patients (N = 13) were performed. A significant decrease of the cross-section area of the fixels in the superior longitudinal fasciculus was observed in the FLE. Results in TLE reflected widespread atrophy of limbic, thalamic, and cortico-striatal connections and tracts directly connected to the temporal lobe (such as the anterior commissure, inferior fronto-occipital fasciculus, uncinate fasciculus, splenium of corpus callosum, and cingulum bundle). Alterations were also observed in extratemporal connections (brainstem connection, commissural fibres, and parts of the superior longitudinal fasciculus). To our knowledge, this is the first study to use an advanced FBA method not only on the datasets of MR-negative TLE patients, but also MR-negative FLE patients, uncovering new common tract-specific alterations on the group level.

Návaznosti

LM2018129, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, National research infrastructure for biological and medical imaging

MUNI/IGA/1044/2020, interní kód MU

Název: Localization of a seizure-onset zone in patients with epilepsy: A structural connectome study (Akronym: EPICOME)

Investor: Masarykova univerzita, Localization of a seizure-onset zone in patients with epilepsy: A structural connectome study

NU21-04-00254, projekt VaV

Název: Detekce zóny počátku záchvatu u multi-lezionální epilepsie s užitím multimodálního neurozobrazování (Akronym: MultiEPI)

Investor: Ministerstvo zdravotnictví ČR, Detekce zóny počátku záchvatu u multi-lezionální epilepsie s užitím multimodálního neurozobrazování, Podprogram 1 - standardní

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

BARTOŇOVÁ, Michaela, Jacques-Donald TOURNIER, Marek BARTOŇ, Pavel ŘÍHA, Lubomír VOJTÍŠEK, Radek MAREČEK, Irena DOLEŽALOVÁ a Ivan REKTOR. White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis. Scientific Reports. Berlin: NATURE PORTFOLIO, 2023, roč. 13, č. 1, s. 1-10. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-27233-4.

@article{2244942,
   author = {Bartoňová, Michaela and Tournier, JacquesandDonald and Bartoň, Marek and Říha, Pavel and Vojtíšek, Lubomír and Mareček, Radek and Doležalová, Irena and Rektor, Ivan},
   article_location = {Berlin},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-022-27233-4},
   keywords = {Focal Epilepsy; Temporal Lobe Epilepsy (TLE); Frontal Lobe Epilepsy (FLE); MR-negative; Fixel-Based Analysis (FBA); Fibre Density; Fibre Cross-section},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis},
   url = {https://www.nature.com/articles/s41598-022-27233-4},
   volume = {13},
   year = {2023}
}

TY  - JOUR
ID  - 2244942
AU  - Bartoňová, Michaela - Tournier, Jacques-Donald - Bartoň, Marek - Říha, Pavel - Vojtíšek, Lubomír - Mareček, Radek - Doležalová, Irena - Rektor, Ivan
PY  - 2023
TI  - White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis
JF  - Scientific Reports
VL  - 13
IS  - 1
SP  - 1-10
EP  - 1-10
PB  - NATURE PORTFOLIO
SN  - 20452322
KW  - Focal Epilepsy
KW  - Temporal Lobe Epilepsy (TLE)
KW  - Frontal Lobe Epilepsy (FLE)
KW  - MR-negative
KW  - Fixel-Based Analysis (FBA)
KW  - Fibre Density
KW  - Fibre Cross-section
UR  - https://www.nature.com/articles/s41598-022-27233-4
N2  - This study focuses on white matter alterations in pharmacoresistant epilepsy patients with no visible lesions in the temporal and frontal lobes on clinical MRI (i.e. MR-negative) with lesions confirmed by resective surgery. The aim of the study was to extend the knowledge about group-specific neuropathology in MR-negative epilepsy. We used the fixel-based analysis (FBA) that overcomes the limitations of traditional diffusion tensor image analysis, mainly within-voxel averaging of multiple crossing fibres. Group-wise comparisons of fixel parameters between healthy controls (N = 100) and: (1) frontal lobe epilepsy (FLE) patients (N = 9); (2) temporal lobe epilepsy (TLE) patients (N = 13) were performed. A significant decrease of the cross-section area of the fixels in the superior longitudinal fasciculus was observed in the FLE. Results in TLE reflected widespread atrophy of limbic, thalamic, and cortico-striatal connections and tracts directly connected to the temporal lobe (such as the anterior commissure, inferior fronto-occipital fasciculus, uncinate fasciculus, splenium of corpus callosum, and cingulum bundle). Alterations were also observed in extratemporal connections (brainstem connection, commissural fibres, and parts of the superior longitudinal fasciculus). To our knowledge, this is the first study to use an advanced FBA method not only on the datasets of MR-negative TLE patients, but also MR-negative FLE patients, uncovering new common tract-specific alterations on the group level.
ER  -

BARTOŇOVÁ, Michaela, Jacques-Donald TOURNIER, Marek BARTOŇ, Pavel ŘÍHA, Lubomír VOJTÍŠEK, Radek MAREČEK, Irena DOLEŽALOVÁ a Ivan REKTOR. White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis. \textit{Scientific Reports}. Berlin: NATURE PORTFOLIO, 2023, roč.~13, č.~1, s.~1-10. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-27233-4.

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