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@article{2244942, author = {Bartoňová, Michaela and Tournier, JacquesandDonald and Bartoň, Marek and Říha, Pavel and Vojtíšek, Lubomír and Mareček, Radek and Doležalová, Irena and Rektor, Ivan}, article_location = {Berlin}, article_number = {1}, doi = {http://dx.doi.org/10.1038/s41598-022-27233-4}, keywords = {Focal Epilepsy; Temporal Lobe Epilepsy (TLE); Frontal Lobe Epilepsy (FLE); MR-negative; Fixel-Based Analysis (FBA); Fibre Density; Fibre Cross-section}, language = {eng}, issn = {2045-2322}, journal = {Scientific Reports}, title = {White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis}, url = {https://www.nature.com/articles/s41598-022-27233-4}, volume = {13}, year = {2023} }
TY - JOUR ID - 2244942 AU - Bartoňová, Michaela - Tournier, Jacques-Donald - Bartoň, Marek - Říha, Pavel - Vojtíšek, Lubomír - Mareček, Radek - Doležalová, Irena - Rektor, Ivan PY - 2023 TI - White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis JF - Scientific Reports VL - 13 IS - 1 SP - 1-10 EP - 1-10 PB - NATURE PORTFOLIO SN - 20452322 KW - Focal Epilepsy KW - Temporal Lobe Epilepsy (TLE) KW - Frontal Lobe Epilepsy (FLE) KW - MR-negative KW - Fixel-Based Analysis (FBA) KW - Fibre Density KW - Fibre Cross-section UR - https://www.nature.com/articles/s41598-022-27233-4 N2 - This study focuses on white matter alterations in pharmacoresistant epilepsy patients with no visible lesions in the temporal and frontal lobes on clinical MRI (i.e. MR-negative) with lesions confirmed by resective surgery. The aim of the study was to extend the knowledge about group-specific neuropathology in MR-negative epilepsy. We used the fixel-based analysis (FBA) that overcomes the limitations of traditional diffusion tensor image analysis, mainly within-voxel averaging of multiple crossing fibres. Group-wise comparisons of fixel parameters between healthy controls (N = 100) and: (1) frontal lobe epilepsy (FLE) patients (N = 9); (2) temporal lobe epilepsy (TLE) patients (N = 13) were performed. A significant decrease of the cross-section area of the fixels in the superior longitudinal fasciculus was observed in the FLE. Results in TLE reflected widespread atrophy of limbic, thalamic, and cortico-striatal connections and tracts directly connected to the temporal lobe (such as the anterior commissure, inferior fronto-occipital fasciculus, uncinate fasciculus, splenium of corpus callosum, and cingulum bundle). Alterations were also observed in extratemporal connections (brainstem connection, commissural fibres, and parts of the superior longitudinal fasciculus). To our knowledge, this is the first study to use an advanced FBA method not only on the datasets of MR-negative TLE patients, but also MR-negative FLE patients, uncovering new common tract-specific alterations on the group level. ER -
BARTOŇOVÁ, Michaela, Jacques-Donald TOURNIER, Marek BARTOŇ, Pavel ŘÍHA, Lubomír VOJTÍŠEK, Radek MAREČEK, Irena DOLEŽALOVÁ a Ivan REKTOR. White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis. \textit{Scientific Reports}. Berlin: NATURE PORTFOLIO, 2023, roč.~13, č.~1, s.~1-10. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-27233-4.
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