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@article{2245219,
author = {Vitale, Chiara Maria and Price, Elliott James and Miller, Gary W and David, Arthur and Antignac, JeanandPhilippe and Barouki, Robert and Klánová, Jana},
article_number = {1},
doi = {http://dx.doi.org/10.1093/exposome/osab003},
keywords = {trace analysis of environmental contaminants; suspect screening and non-target analysis; exposome and metabolome; SPE and passive sampling/SPME; LC-HRMS and GC-HRMS; chemicals of emerging concern},
language = {eng},
issn = {2635-2265},
journal = {Exposome},
title = {Analytical strategies for chemical exposomics: exploring limits and feasibility},
url = {https://academic.oup.com/exposome/article/1/1/osab003/6372691},
volume = {1},
year = {2021}
}
TY - JOUR
ID - 2245219
AU - Vitale, Chiara Maria - Price, Elliott James - Miller, Gary W - David, Arthur - Antignac, Jean-Philippe - Barouki, Robert - Klánová, Jana
PY - 2021
TI - Analytical strategies for chemical exposomics: exploring limits and feasibility
JF - Exposome
VL - 1
IS - 1
SP - 1-18
EP - 1-18
PB - Oxford University Press
SN - 26352265
KW - trace analysis of environmental contaminants
KW - suspect screening and non-target analysis
KW - exposome and metabolome
KW - SPE and passive sampling/SPME
KW - LC-HRMS and GC-HRMS
KW - chemicals of emerging concern
UR - https://academic.oup.com/exposome/article/1/1/osab003/6372691
N2 - Tackling the challenges of chemical exposomics will require the implementation of diverse analytical strategies and technological advancements. Herein, high-resolution mass spectrometry-based methods applied in current chemical exposome studies have been surveyed and are shown to be limited. Notably, liquid chromatography separations almost exclusively employ reversed-phase C18 columns using water/methanol gradients with formic acid additive, while gas chromatography is underexploited in the field at this stage. A systematic evaluation of strategies applied in related disciplines (i.e. metabolomics, proteomics, multiresidue trace analysis) was undertaken to provide practical guidance for the development of chemical exposomics. The approaches were assessed on the basis of their costs (i.e. capital expenditure, overhead and maintenance fees, expertise required, consumables) and potential benefits (i.e. improvements to sensitivity, coverage, reproducibility, throughput, ease of use) to prioritize those with promise for chemical exposomics application. Alongside a need for technological investments (e.g. advanced hardware updates), numerous low-cost strategies showed high potential benefits (e.g. different column phases, enhanced sample fractionation) and are feasible for rapid adoption.
ER -
VITALE, Chiara Maria, Elliott James PRICE, Gary W MILLER, Arthur DAVID, Jean-Philippe ANTIGNAC, Robert BAROUKI a Jana KLÁNOVÁ. Analytical strategies for chemical exposomics: exploring limits and feasibility. \textit{Exposome}. Oxford University Press, 2021, roč.~1, č.~1, s.~1-18. ISSN~2635-2265. Dostupné z: https://dx.doi.org/10.1093/exposome/osab003.
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