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@article{2245230,
author = {Štundlová, Jana and Hospodářská, Monika and Lukšíková, Karolína and Voleníková, Anna and Pavlica, Tomáš and Altmanová, Marie and Richter, Annekatrin and Reichard, Martin and Dalíková, Martina and Pelikánová, Šárka and Marta, Anatolie and Simanovsky, Sergey A. and Hiřman, Matyáš and Jankásek, Marek and Dvořák, Tomáš and Bohlen, Joerg and Ráb, Petr and Englert, Christoph and Nguyen, Petr and Sember, Alexandr},
article_number = {4},
doi = {http://dx.doi.org/10.1007/s10577-022-09707-3},
keywords = {Inversion; Recombination suppression; Sex chromosome degeneration; Repeatome; RepeatExplorer; Sex chromosome polymorphism},
language = {eng},
issn = {0967-3849},
journal = {Chromosome Research},
title = {Sex chromosome differentiation via changes in the Y chromosome repeat landscape in African annual killifishes Nothobranchius furzeri and N. kadleci},
url = {https://doi.org/10.1007/s10577-022-09707-3},
volume = {30},
year = {2022}
}
TY - JOUR
ID - 2245230
AU - Štundlová, Jana - Hospodářská, Monika - Lukšíková, Karolína - Voleníková, Anna - Pavlica, Tomáš - Altmanová, Marie - Richter, Annekatrin - Reichard, Martin - Dalíková, Martina - Pelikánová, Šárka - Marta, Anatolie - Simanovsky, Sergey A. - Hiřman, Matyáš - Jankásek, Marek - Dvořák, Tomáš - Bohlen, Joerg - Ráb, Petr - Englert, Christoph - Nguyen, Petr - Sember, Alexandr
PY - 2022
TI - Sex chromosome differentiation via changes in the Y chromosome repeat landscape in African annual killifishes Nothobranchius furzeri and N. kadleci
JF - Chromosome Research
VL - 30
IS - 4
SP - 309-333
EP - 309-333
PB - Springer Netherlands
SN - 09673849
KW - Inversion
KW - Recombination suppression
KW - Sex chromosome degeneration
KW - Repeatome
KW - RepeatExplorer
KW - Sex chromosome polymorphism
UR - https://doi.org/10.1007/s10577-022-09707-3
N2 - Homomorphic sex chromosomes and their turnover are common in teleosts. We investigated the evolution of nascent sex chromosomes in several populations of two sister species of African annual killifishes, Nothobranchius furzeri and N. kadleci, focusing on their under-studied repetitive landscape. We combined bioinformatic analyses of the repeatome with molecular cytogenetic techniques, including comparative genomic hybridization, fluorescence in situ hybridization with satellite sequences, ribosomal RNA genes (rDNA) and bacterial artificial chromosomes (BACs), and immunostaining of SYCP3 and MLH1 proteins to mark lateral elements of synaptonemal complexes and recombination sites, respectively. Both species share the same heteromorphic XY sex chromosome system, which thus evolved prior to their divergence. This was corroborated by sequence analysis of a putative master sex determining (MSD) gene gdf6Y in both species. Based on their divergence, differentiation of the XY sex chromosome pair started approximately 2 million years ago. In all populations, the gdf6Y gene mapped within a region rich in satellite DNA on the Y chromosome long arms. Despite their heteromorphism, X and Y chromosomes mostly pair regularly in meiosis, implying synaptic adjustment. In N. kadleci, Y-linked paracentric inversions like those previously reported in N. furzeri were detected. An inversion involving the MSD gene may suppress occasional recombination in the region, which we otherwise evidenced in the N. furzeri population MZCS-121 of the Limpopo clade lacking this inversion. Y chromosome centromeric repeats were reduced compared with the X chromosome and autosomes, which points to a role of relaxed meiotic drive in shaping the Y chromosome repeat landscape. We speculate that the recombination rate between sex chromosomes was reduced due to heterochiasmy. The observed differences between the repeat accumulations on the X and Y chromosomes probably result from high repeat turnover and may not relate closely to the divergence inferred from earlier SNP analyses.
ER -
ŠTUNDLOVÁ, Jana, Monika HOSPODÁŘSKÁ, Karolína LUKŠÍKOVÁ, Anna VOLENÍKOVÁ, Tomáš PAVLICA, Marie ALTMANOVÁ, Annekatrin RICHTER, Martin REICHARD, Martina DALÍKOVÁ, Šárka PELIKÁNOVÁ, Anatolie MARTA, Sergey A. SIMANOVSKY, Matyáš HIŘMAN, Marek JANKÁSEK, Tomáš DVOŘÁK, Joerg BOHLEN, Petr RÁB, Christoph ENGLERT, Petr NGUYEN a Alexandr SEMBER. Sex chromosome differentiation via changes in the Y chromosome repeat landscape in African annual killifishes Nothobranchius furzeri and N. kadleci. \textit{Chromosome Research}. Springer Netherlands, 2022, roč.~30, č.~4, s.~309-333. ISSN~0967-3849. Dostupné z: https://dx.doi.org/10.1007/s10577-022-09707-3.
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