Photoinduced water-chromophore electron transfer causes
formation of guanosine photodamage

J 2022

Photoinduced water-chromophore electron transfer causes formation of guanosine photodamage

JANICKI, Mikolaj J., Rafal Kazimierz SZABLA, Jiří ŠPONER a Robert W. GORA

Základní údaje

Originální název

Photoinduced water-chromophore electron transfer causes formation of guanosine photodamage

Autoři

JANICKI, Mikolaj J., Rafal Kazimierz SZABLA, Jiří ŠPONER (203 Česká republika, domácí) a Robert W. GORA (garant)

Vydání

Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2022, 1463-9076

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10403 Physical chemistry

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.300

Kód RIV

RIV/00216224:14310/22:00127885

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1039/d2cp00801g

UT WoS

000772126600001

Klíčová slova anglicky

2ND-ORDER PERTURBATION-THEORY; INDUCED DNA-DAMAGE; GUANINE DERIVATIVES; MAJOR PRODUCTS; BASIS-SETS; UV; DYNAMICS; STATE; PHOTOCHEMISTRY; ABSORPTION

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 1. 2023 14:55, Mgr. Marie Šípková, DiS.

Anotace

V originále

UV-induced photolysis of aqueous guanine nucleosides produces 8-oxo-guanine and Fapy-guanine, which can induce various types of cellular malfunction. The mechanistic rationale underlying photodestructive processes of guanine nucleosides is still largely obscure. Here, we employ accurate quantum chemical calculations and demonstrate that an excited-state non-bonding interaction of guanosine and a water molecule facilitates the electron-driven proton transfer process from water to the chromophore fragment. This subsequently allows for the formation of a crucial intermediate, namely guanosine photohydrate. Further (photo)chemical reactions of this intermediate lead to the known products of guanine photodamage.

Citovat

JANICKI, Mikolaj J., Rafal Kazimierz SZABLA, Jiří ŠPONER a Robert W. GORA. Photoinduced water-chromophore electron transfer causes formation of guanosine photodamage. Physical Chemistry Chemical Physics. Royal Society of Chemistry, 2022, roč. 24, č. 14, s. 8217-8224. ISSN 1463-9076. Dostupné z: https://dx.doi.org/10.1039/d2cp00801g.

@article{2245535,
   author = {Janicki, Mikolaj J. and Szabla, Rafal Kazimierz and Šponer, Jiří and Gora, Robert W.},
   article_number = {14},
   doi = {http://dx.doi.org/10.1039/d2cp00801g},
   keywords = {2ND-ORDER PERTURBATION-THEORY; INDUCED DNA-DAMAGE; GUANINE DERIVATIVES; MAJOR PRODUCTS; BASIS-SETS; UV; DYNAMICS; STATE; PHOTOCHEMISTRY; ABSORPTION},
   language = {eng},
   issn = {1463-9076},
   journal = {Physical Chemistry Chemical Physics},
   title = {Photoinduced water-chromophore electron transfer causes formation of guanosine photodamage},
   url = {https://pubs.rsc.org/en/content/articlelanding/2022/cp/d2cp00801g},
   volume = {24},
   year = {2022}
}

TY  - JOUR
ID  - 2245535
AU  - Janicki, Mikolaj J. - Szabla, Rafal Kazimierz - Šponer, Jiří - Gora, Robert W.
PY  - 2022
TI  - Photoinduced water-chromophore electron transfer causes formation of guanosine photodamage
JF  - Physical Chemistry Chemical Physics
VL  - 24
IS  - 14
SP  - 8217-8224
EP  - 8217-8224
PB  - Royal Society of Chemistry
SN  - 14639076
KW  - 2ND-ORDER PERTURBATION-THEORY
KW  - INDUCED DNA-DAMAGE
KW  - GUANINE DERIVATIVES
KW  - MAJOR PRODUCTS
KW  - BASIS-SETS
KW  - UV
KW  - DYNAMICS
KW  - STATE
KW  - PHOTOCHEMISTRY
KW  - ABSORPTION
UR  - https://pubs.rsc.org/en/content/articlelanding/2022/cp/d2cp00801g
N2  - UV-induced photolysis of aqueous guanine nucleosides produces 8-oxo-guanine and Fapy-guanine, which can induce various types of cellular malfunction. The mechanistic rationale underlying photodestructive processes of guanine nucleosides is still largely obscure. Here, we employ accurate quantum chemical calculations and demonstrate that an excited-state non-bonding interaction of guanosine and a water molecule facilitates the electron-driven proton transfer process from water to the chromophore fragment. This subsequently allows for the formation of a crucial intermediate, namely guanosine photohydrate. Further (photo)chemical reactions of this intermediate lead to the known products of guanine photodamage.
ER  -

JANICKI, Mikolaj J., Rafal Kazimierz SZABLA, Jiří ŠPONER a Robert W. GORA. Photoinduced water-chromophore electron transfer causes formation of guanosine photodamage. \textit{Physical Chemistry Chemical Physics}. Royal Society of Chemistry, 2022, roč.~24, č.~14, s.~8217-8224. ISSN~1463-9076. Dostupné z: https://dx.doi.org/10.1039/d2cp00801g.

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