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@article{2247014,
author = {Izakovičová, Pavla and Slezáková, Simona and Zakostelska Jiraskova, Zuzana and Šístková, Jana and Mlčůchová, Natálie and Bartova, Jirina and Petanova, Jitka and Kuklínek, Pavel and Fassmann, Antonín and Dušek, Ladislav and Izakovičová Hollá, Lydie and Bořilová Linhartová, Petra},
article_location = {HOBOKEN},
article_number = {1},
doi = {http://dx.doi.org/10.1111/jop.13385},
keywords = {haplogenotype; haplotype; MBL; polymorphism; recurrent aphthous stomatitis},
language = {eng},
issn = {0904-2512},
journal = {JOURNAL OF ORAL PATHOLOGY & MEDICINE},
title = {Gene polymorphisms and serum levels of mannose-binding lectin in Czech patients with recurrent aphthous stomatitis: A case-control study},
url = {https://onlinelibrary.wiley.com/doi/10.1111/jop.13385},
volume = {52},
year = {2023}
}
TY - JOUR
ID - 2247014
AU - Izakovičová, Pavla - Slezáková, Simona - Zakostelska Jiraskova, Zuzana - Šístková, Jana - Mlčůchová, Natálie - Bartova, Jirina - Petanova, Jitka - Kuklínek, Pavel - Fassmann, Antonín - Dušek, Ladislav - Izakovičová Hollá, Lydie - Bořilová Linhartová, Petra
PY - 2023
TI - Gene polymorphisms and serum levels of mannose-binding lectin in Czech patients with recurrent aphthous stomatitis: A case-control study
JF - JOURNAL OF ORAL PATHOLOGY & MEDICINE
VL - 52
IS - 1
SP - 81-90
EP - 81-90
PB - WILEY
SN - 09042512
KW - haplogenotype
KW - haplotype
KW - MBL
KW - polymorphism
KW - recurrent aphthous stomatitis
UR - https://onlinelibrary.wiley.com/doi/10.1111/jop.13385
N2 - Background: Recurrent aphthous stomatitis is one of the most prevalent oral mucosal immunological diseases. A recent case-control study in the Egyptian population suggested that single nucleotide polymorphism Gly54Asp (rs1800450) of the mannose-binding lectin 2 gene might affect the mannose-binding lectin serum level and recurrent aphthous stomatitis development. The aim of this study was to determine the distribution of six functional mannose-binding lectin 2 gene polymorphisms and analyse their role in recurrent aphthous stomatitis susceptibility in the Czech population. Methods: The study included 227 subjects; 137 healthy people and 90 patients with recurrent aphthous stomatitis. Six mannose-binding lectin 2 gene polymorphisms (rs11003125, rs7096206, rs7095891, rs5030737, rs1800450, rs1800451) were analysed by the SNaPshot assay method, mannose-binding lectin serum levels were determined by enzyme-linked immunosorbent assay (ELISA) method in a subgroup of subjects (N = 87). Results: No significant differences in mean of mannose-binding lectin serum levels between healthy controls and patients with recurrent aphthous stomatitis were observed (383 ng/ml +/- 249 standard deviation (SD) vs. 316 ng/ml +/- 177 SD in remission phase vs. 343 ng/ml +/- 254 SD in active phase; p > 0.05), also the allele and genotype frequencies of the studied mannose-binding lectin 2 polymorphisms did not differ significantly between the two groups (p > 0.05, odds ratio (OR): 0.75-1.23). Moreover, the distribution of mannose-binding lectin 2 haplotypes and haplogenotypes was similar in the healthy subjects and patients with recurrent aphthous stomatitis (p > 0.05, OR: 0.75-1.23). Conclusions: This study did not confirm the previously reported association of the mannose-binding lectin 2 Gly54Asp gene variant and low mannose-binding lectin serum level as the risk factors for susceptibility to recurrent aphthous stomatitis. In addition, no significant relationships between mannose-binding lectin 2 functional haplotypes or haplogenotypes and recurrent aphthous stomatitis were observed.
ER -
IZAKOVIČOVÁ, Pavla, Simona SLEZÁKOVÁ, Zuzana ZAKOSTELSKA JIRASKOVA, Jana ŠÍSTKOVÁ, Natálie MLČŮCHOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLÍNEK, Antonín FASSMANN, Ladislav DUŠEK, Lydie IZAKOVIČOVÁ HOLLÁ a Petra BOŘILOVÁ LINHARTOVÁ. Gene polymorphisms and serum levels of mannose-binding lectin in Czech patients with recurrent aphthous stomatitis: A case-control study. \textit{JOURNAL OF ORAL PATHOLOGY \&{} MEDICINE}. HOBOKEN: WILEY, 2023, roč.~52, č.~1, s.~81-90. ISSN~0904-2512. Dostupné z: https://dx.doi.org/10.1111/jop.13385.
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