Anesthetized Guinea Pig as a Model for Drug Testing

J 2022

Anesthetized Guinea Pig as a Model for Drug Testing

BARTÁKOVÁ, Anna, Marie NOVÁKOVÁ a Tibor STRAČINA

Základní údaje

Originální název

Anesthetized Guinea Pig as a Model for Drug Testing

Autoři

BARTÁKOVÁ, Anna (203 Česká republika, domácí), Marie NOVÁKOVÁ (203 Česká republika, domácí) a Tibor STRAČINA (703 Slovensko, garant, domácí)

Vydání

Physiological Research, PRAGUE, ACAD SCIENCES CZECH REPUBLIC, 2022, 0862-8408

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.100

Kód RIV

RIV/00216224:14110/22:00128065

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.33549/physiolres.934994

UT WoS

000924861700006

Klíčová slova anglicky

Adrenergic agents; Animal model; Cardiovascular system; Drug testing; Guinea pig

Štítky

14110515, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 4. 2023 08:26, Mgr. Tereza Miškechová

Anotace

V originále

Based on the World Health Organization statistics, cardiovascular diseases represent the major cause of death worldwide. Although a wide range of treatment approaches and pharmaceuticals is available, the therapy is often not effective enough and therefore health risks for the patient persist. Thus, it is still essential to test new drug candidates for the treatment of various pathophysiological conditions related to cardiovascular system. In vivo models represent indispensable part of preclinical testing of such substances. Anesthetized guinea pig as a whole-body model allows to evaluate complex reactions of cardiovascular system to tested substance. Moreover, action potential of guinea pig cardiomyocyte is quite comparable to that of human. Hence, the results from this model are then quite well translatable to clinical medicine. Aim of this paper was to summarize the methodology of this model, including its advantages and/or limitations and risks, based on the effects of two substances with adrenergic activity on the ECG parameters. The model of anesthetized guinea pig proved to be valuable and suitable for testing of drugs with cardiovascular effects.

Návaznosti

EF19_073/0016943, projekt VaV

Název: Interní grantová agentura Masarykovy univerzity

MUNI/IGA/1098/2020, interní kód MU

Název: Arrhythmogenic potential of TP-1 in animal model

Investor: Masarykova univerzita, Arrhythmogenic potential of TP-1 in animal model

Citovat

BARTÁKOVÁ, Anna, Marie NOVÁKOVÁ a Tibor STRAČINA. Anesthetized Guinea Pig as a Model for Drug Testing. Physiological Research. PRAGUE: ACAD SCIENCES CZECH REPUBLIC, 2022, roč. 71, Supplement 2, s. "S211"-"S218", 8 s. ISSN 0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.934994.

@article{2247518,
   author = {Bartáková, Anna and Nováková, Marie and Stračina, Tibor},
   article_location = {PRAGUE},
   article_number = {Supplement 2},
   doi = {http://dx.doi.org/10.33549/physiolres.934994},
   keywords = {Adrenergic agents; Animal model; Cardiovascular system; Drug testing; Guinea pig},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Anesthetized Guinea Pig as a Model for Drug Testing},
   url = {https://www.biomed.cas.cz/physiolres/pdf/2022/71_S211.pdf},
   volume = {71},
   year = {2022}
}

TY  - JOUR
ID  - 2247518
AU  - Bartáková, Anna - Nováková, Marie - Stračina, Tibor
PY  - 2022
TI  - Anesthetized Guinea Pig as a Model for Drug Testing
JF  - Physiological Research
VL  - 71
IS  - Supplement 2
SP  - "S211"-"S218"
EP  - "S211"-"S218"
PB  - ACAD SCIENCES CZECH REPUBLIC
SN  - 08628408
KW  - Adrenergic agents
KW  - Animal model
KW  - Cardiovascular system
KW  - Drug testing
KW  - Guinea pig
UR  - https://www.biomed.cas.cz/physiolres/pdf/2022/71_S211.pdf
N2  - Based on the World Health Organization statistics, cardiovascular diseases represent the major cause of death worldwide. Although a wide range of treatment approaches and pharmaceuticals is available, the therapy is often not effective enough and therefore health risks for the patient persist. Thus, it is still essential to test new drug candidates for the treatment of various pathophysiological conditions related to cardiovascular system. In vivo models represent indispensable part of preclinical testing of such substances. Anesthetized guinea pig as a whole-body model allows to evaluate complex reactions of cardiovascular system to tested substance. Moreover, action potential of guinea pig cardiomyocyte is quite comparable to that of human. Hence, the results from this model are then quite well translatable to clinical medicine. Aim of this paper was to summarize the methodology of this model, including its advantages and/or limitations and risks, based on the effects of two substances with adrenergic activity on the ECG parameters. The model of anesthetized guinea pig proved to be valuable and suitable for testing of drugs with cardiovascular effects.
ER  -

BARTÁKOVÁ, Anna, Marie NOVÁKOVÁ a Tibor STRAČINA. Anesthetized Guinea Pig as a Model for Drug Testing. \textit{Physiological Research}. PRAGUE: ACAD SCIENCES CZECH REPUBLIC, 2022, roč.~71, Supplement 2, s.~''S211''-''S218'', 8 s. ISSN~0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.934994.

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