Tremor associated with similar structural networks in
Parkinson's disease and essential tremor

J 2022

Tremor associated with similar structural networks in Parkinson's disease and essential tremor

FILIP, Pavel, Kristina BURDOVA, Zdenek VALENTA, Robert JECH, Viktória KOKOŠOVÁ et. al.

Základní údaje

Originální název

Tremor associated with similar structural networks in Parkinson's disease and essential tremor

Autoři

FILIP, Pavel (703 Slovensko, garant), Kristina BURDOVA (203 Česká republika), Zdenek VALENTA (203 Česká republika), Robert JECH (203 Česká republika), Viktória KOKOŠOVÁ (703 Slovensko, domácí), Marek BALÁŽ (703 Slovensko, domácí), Silvia MANGIA, Shalom MICHAELI, Martin BAREŠ (203 Česká republika, domácí) a Lubomír VOJTÍŠEK (203 Česká republika, domácí)

Vydání

PARKINSONISM & RELATED DISORDERS, OXFORD, ELSEVIER SCI LTD, 2022, 1353-8020

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.100

Kód RIV

RIV/00216224:14110/22:00128076

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.parkreldis.2021.12.014

UT WoS

000749847700006

Klíčová slova anglicky

Tremor; Probabilistic tractography; Structural connectome; Parkinson 's disease; Essential tremor

Štítky

14110127, 14110221, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 10. 2024 10:06, Ing. Jana Kuchtová

Anotace

V originále

Introduction: Despite substantial clinical and pathophysiological differences, the characteristics of tremor in Parkinson's disease (PD) and essential tremor (ET) patients bear certain similarities. The presented study delineates tremor-related structural networks in these two disorders. Methods: 42 non-advanced PD patients (18 tremor-dominant, 24 without substantial tremor), 17 ET, and 45 healthy controls underwent high-angular resolution diffusion-weighted imaging acquisition to reconstruct their structural motor connectomes as a proxy of the anatomical interconnections between motor network regions, implementing state-of-the-art globally optimised probabilistic tractography. Results: When compared to healthy controls, ET patients exhibited higher structural connectivity in the cerebellothalamo-cortical network. Interestingly, the comparison of tremor-dominant PD patients and PD patients without tremor yielded very similar results - higher structural connectivity in tremor-dominant PD sharing multiple nodes with the tremor network detected in ET, despite the generally lower structural connectivity between basal ganglia and frontal cortex in the whole PD group when compared to healthy controls. Conclusion: The higher structural connectivity of the cerebello-thalamo-cortical network seems to be the dominant tremor driver in both PD and ET. While it appears to be the only tremor-related network in ET, its combination with large scale hypoconnectivity in the frontal cortico-subcortical network in PD may explain different clinical features of tremor in these two disorders.

Návaznosti

691110, interní kód MU

Název: Advanced MR methods for characterization of microstructural brain damage (MICROBRADAM) (Akronym: MICROBRADAM)

Investor: Evropská unie, Advanced MR methods for characterization of microstructural brain damage (MICROBRADAM), MSCA Marie Skłodowska-Curie Actions (Excellent Science)

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

FILIP, Pavel, Kristina BURDOVA, Zdenek VALENTA, Robert JECH, Viktória KOKOŠOVÁ, Marek BALÁŽ, Silvia MANGIA, Shalom MICHAELI, Martin BAREŠ a Lubomír VOJTÍŠEK. Tremor associated with similar structural networks in Parkinson's disease and essential tremor. PARKINSONISM & RELATED DISORDERS. OXFORD: ELSEVIER SCI LTD, 2022, roč. 95, February 2022, s. 28-34. ISSN 1353-8020. Dostupné z: https://dx.doi.org/10.1016/j.parkreldis.2021.12.014.

@article{2247547,
   author = {Filip, Pavel and Burdova, Kristina and Valenta, Zdenek and Jech, Robert and Kokošová, Viktória and Baláž, Marek and Mangia, Silvia and Michaeli, Shalom and Bareš, Martin and Vojtíšek, Lubomír},
   article_location = {OXFORD},
   article_number = {February 2022},
   doi = {http://dx.doi.org/10.1016/j.parkreldis.2021.12.014},
   keywords = {Tremor; Probabilistic tractography; Structural connectome; Parkinson 's disease; Essential tremor},
   language = {eng},
   issn = {1353-8020},
   journal = {PARKINSONISM & RELATED DISORDERS},
   title = {Tremor associated with similar structural networks in Parkinson's disease and essential tremor},
   url = {https://www.sciencedirect.com/science/article/pii/S1353802021004697?via%3Dihub},
   volume = {95},
   year = {2022}
}

TY  - JOUR
ID  - 2247547
AU  - Filip, Pavel - Burdova, Kristina - Valenta, Zdenek - Jech, Robert - Kokošová, Viktória - Baláž, Marek - Mangia, Silvia - Michaeli, Shalom - Bareš, Martin - Vojtíšek, Lubomír
PY  - 2022
TI  - Tremor associated with similar structural networks in Parkinson's disease and essential tremor
JF  - PARKINSONISM & RELATED DISORDERS
VL  - 95
IS  - February 2022
SP  - 28-34
EP  - 28-34
PB  - ELSEVIER SCI LTD
SN  - 13538020
KW  - Tremor
KW  - Probabilistic tractography
KW  - Structural connectome
KW  - Parkinson 's disease
KW  - Essential tremor
UR  - https://www.sciencedirect.com/science/article/pii/S1353802021004697?via%3Dihub
N2  - Introduction: Despite substantial clinical and pathophysiological differences, the characteristics of tremor in Parkinson's disease (PD) and essential tremor (ET) patients bear certain similarities. The presented study delineates tremor-related structural networks in these two disorders. Methods: 42 non-advanced PD patients (18 tremor-dominant, 24 without substantial tremor), 17 ET, and 45 healthy controls underwent high-angular resolution diffusion-weighted imaging acquisition to reconstruct their structural motor connectomes as a proxy of the anatomical interconnections between motor network regions, implementing state-of-the-art globally optimised probabilistic tractography. Results: When compared to healthy controls, ET patients exhibited higher structural connectivity in the cerebellothalamo-cortical network. Interestingly, the comparison of tremor-dominant PD patients and PD patients without tremor yielded very similar results - higher structural connectivity in tremor-dominant PD sharing multiple nodes with the tremor network detected in ET, despite the generally lower structural connectivity between basal ganglia and frontal cortex in the whole PD group when compared to healthy controls. Conclusion: The higher structural connectivity of the cerebello-thalamo-cortical network seems to be the dominant tremor driver in both PD and ET. While it appears to be the only tremor-related network in ET, its combination with large scale hypoconnectivity in the frontal cortico-subcortical network in PD may explain different clinical features of tremor in these two disorders.
ER  -

FILIP, Pavel, Kristina BURDOVA, Zdenek VALENTA, Robert JECH, Viktória KOKOŠOVÁ, Marek BALÁŽ, Silvia MANGIA, Shalom MICHAELI, Martin BAREŠ a Lubomír VOJTÍŠEK. Tremor associated with similar structural networks in Parkinson's disease and essential tremor. \textit{PARKINSONISM \&{} RELATED DISORDERS}. OXFORD: ELSEVIER SCI LTD, 2022, roč.~95, February 2022, s.~28-34. ISSN~1353-8020. Dostupné z: https://dx.doi.org/10.1016/j.parkreldis.2021.12.014.

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