IVANOV, Vladimir, Su-Peng YEH, Jiří MAYER, Lalit SAINI, Ali UNAL, Michael BOYIADZIS, David M HOFFMAN, Kingston KANG, Sadiya N ADDO, Wellington L MENDES a Amir T FATHI. Design of the VIALE-M phase III trial of venetoclax and oral azacitidine maintenance therapy in acute myeloid leukemia. Future Oncology. London: Future Medicine Ltd., 2022, roč. 18, č. 26, s. 2879-2889. ISSN 1479-6694. Dostupné z: https://dx.doi.org/10.2217/fon-2022-0450. |
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@article{2247606, author = {Ivanov, Vladimir and Yeh, SuandPeng and Mayer, Jiří and Saini, Lalit and Unal, Ali and Boyiadzis, Michael and Hoffman, David M and Kang, Kingston and Addo, Sadiya N and Mendes, Wellington L and Fathi, Amir T}, article_location = {London}, article_number = {26}, doi = {http://dx.doi.org/10.2217/fon-2022-0450}, keywords = {acute myeloid leukemia; BCL-2 inhibitor; CC-486 (oral azacitidine); first remission; maintenance therapy; minimal residual disease conversion; phase III; relapse-free survival; venetoclax}, language = {eng}, issn = {1479-6694}, journal = {Future Oncology}, title = {Design of the VIALE-M phase III trial of venetoclax and oral azacitidine maintenance therapy in acute myeloid leukemia}, url = {https://www.futuremedicine.com/doi/10.2217/fon-2022-0450}, volume = {18}, year = {2022} }
TY - JOUR ID - 2247606 AU - Ivanov, Vladimir - Yeh, Su-Peng - Mayer, Jiří - Saini, Lalit - Unal, Ali - Boyiadzis, Michael - Hoffman, David M - Kang, Kingston - Addo, Sadiya N - Mendes, Wellington L - Fathi, Amir T PY - 2022 TI - Design of the VIALE-M phase III trial of venetoclax and oral azacitidine maintenance therapy in acute myeloid leukemia JF - Future Oncology VL - 18 IS - 26 SP - 2879-2889 EP - 2879-2889 PB - Future Medicine Ltd. SN - 14796694 KW - acute myeloid leukemia KW - BCL-2 inhibitor KW - CC-486 (oral azacitidine) KW - first remission KW - maintenance therapy KW - minimal residual disease conversion KW - phase III KW - relapse-free survival KW - venetoclax UR - https://www.futuremedicine.com/doi/10.2217/fon-2022-0450 N2 - Prevention of relapse is a major therapeutic challenge and an unmet need for patients with acute myeloid leukemia (AML). Venetoclax is a highly selective, potent, oral BCL-2 inhibitor that induces apoptosis in AML cells. When combined with azacitidine, it leads to prolonged overall survival and rapid, durable remissions in treatment-naive AML patients ineligible for intensive chemotherapy. VIALE-M is a randomized, double-blind, two-arm study to evaluate the safety and efficacy of venetoclax in combination with oral azacitidine (CC-486) as maintenance therapy in patients in complete remission with incomplete blood count recovery after intensive induction and consolidation therapies. The primary end point is relapse-free survival. Secondary outcomes include overall survival, minimal residual disease conversion and improvement in quality-of-life. ER -
IVANOV, Vladimir, Su-Peng YEH, Jiří MAYER, Lalit SAINI, Ali UNAL, Michael BOYIADZIS, David M HOFFMAN, Kingston KANG, Sadiya N ADDO, Wellington L MENDES a Amir T FATHI. Design of the VIALE-M phase III trial of venetoclax and oral azacitidine maintenance therapy in acute myeloid leukemia. \textit{Future Oncology}. London: Future Medicine Ltd., 2022, roč.~18, č.~26, s.~2879-2889. ISSN~1479-6694. Dostupné z: https://dx.doi.org/10.2217/fon-2022-0450.
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