Další formáty:
BibTeX
LaTeX
RIS
@article{2248076, author = {Dastych, Milan and Šenkyřík, Michal and Mikušková, Alena and Dastych, Milan}, article_location = {CAMBRIDGE}, article_number = {9}, doi = {http://dx.doi.org/10.1017/S0007114522002008}, keywords = {Home parenteral nutrition; Essential amino acids; Ion exchange chromatography; Quality of life}, language = {eng}, issn = {0007-1145}, journal = {British Journal of Nutrition}, title = {Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine}, url = {https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/longterm-home-parenteral-nutrition-and-profile-of-amino-acids-in-serum-and-their-loss-in-urine/F9AE53803D7AA9C4D5C24F1314EE51BF}, volume = {129}, year = {2023} }
TY - JOUR ID - 2248076 AU - Dastych, Milan - Šenkyřík, Michal - Mikušková, Alena - Dastych, Milan PY - 2023 TI - Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine JF - British Journal of Nutrition VL - 129 IS - 9 SP - 1537-1542 EP - 1537-1542 PB - Cambridge University Press SN - 00071145 KW - Home parenteral nutrition KW - Essential amino acids KW - Ion exchange chromatography KW - Quality of life UR - https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/longterm-home-parenteral-nutrition-and-profile-of-amino-acids-in-serum-and-their-loss-in-urine/F9AE53803D7AA9C4D5C24F1314EE51BF N2 - Amino acids are an essential part of parenteral nutrition. This study aimed to determine the serum profile of amino acids and their loss in urine in patients with long-term home parenteral nutrition (HPN) during 12 h of infusion in comparison with similar parameters in the remaining 12 has well as in healthy participants. We enrolled forty-five patients with long-term HPN for 6-75 (median, 33) months. The indication for HPN was short bowel syndrome secondary to radical resection of the small intestine following complications of Crohn's disease. HPN was administered via two-chamber all-in-one bags prepared in a hospital pharmacy overnight for 12 h each day. The average dose of amino acids, carbohydrates and fats administered was 1.5, 3.4 and 0.68 g/kg per d, respectively, at an infusion rate of 0.11, 0.28 and 0.06 g/kg per h, respectively. The levels of essential amino acids in the serum of the patients were not significantly different from those in healthy individuals; however, of the non-essential amino acids, cystine and glutamine levels were lower and glycine and ornithine levels were higher in the patients (P < 0.05). Excretion of amino acids in the urine during 12 h of infusion at an infusion rate of 0.11 g/kg per h was 301 mg, while it was 104 mg during the remaining 12 h (P < 0.0001). Our patients on long-term HPN had a normal serum profile of essential amino acids. The total urinary excretion of amino acids during 12 h of infusion accounted for only 0.34 % (0-23-0.46) of the administered dose. ER -
DASTYCH, Milan, Michal ŠENKYŘÍK, Alena MIKUŠKOVÁ a Milan DASTYCH. Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine. \textit{British Journal of Nutrition}. CAMBRIDGE: Cambridge University Press, 2023, roč.~129, č.~9, s.~1537-1542. ISSN~0007-1145. Dostupné z: https://dx.doi.org/10.1017/S0007114522002008.
|