J 2022

Insomnia in patients treated with checkpoint inhibitors for cancer: A meta-analysis

KISS, Igor, Matyáš KUHN, Kristian HRUSAK, Benjamin BUCHLER, Ludmila BOUBLIKOVA et. al.

Základní údaje

Originální název

Insomnia in patients treated with checkpoint inhibitors for cancer: A meta-analysis

Autoři

KISS, Igor (203 Česká republika, domácí), Matyáš KUHN (203 Česká republika, domácí), Kristian HRUSAK (203 Česká republika), Benjamin BUCHLER (203 Česká republika), Ludmila BOUBLIKOVA (203 Česká republika) a Tomas BUCHLER (203 Česká republika, garant)

Vydání

Frontiers in Oncology, Lausanne, Frontiers Media S.A. 2022, 2234-943X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 4.700

Kód RIV

RIV/00216224:14110/22:00128174

Organizační jednotka

Lékařská fakulta

UT WoS

000841262600001

Klíčová slova anglicky

immunotherapy; cancer; checkpoint inhibitors; insomnia; systematic analysis

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 20. 1. 2023 13:53, Mgr. Tereza Miškechová

Anotace

V originále

Purpose: Insomnia in cancer patients is a common symptom contributing to poor quality of life and poor functioning. Sleep disturbances have been associated with inflammatory activity, and systemic cancer therapies chemotherapy, hormonal therapy, and immunotherapy may cause insomnia. We have carried out a meta-analysis to estimate the occurrence of insomnia in patients with solid cancer treated with immunotherapy using checkpoint inhibitors (CPI). Methods: PubMed and ClinicalTrials.gov were searched for phase 3 studies in solid tumours where treatment included a checkpoint inhibitor in the experimental arm. Data on the incidence of insomnia were acquired from the adverse events tables available from clinicaltrials.gov and/or from the full texts. Random effect logistic model was used to compare pooled data. Heterogeneity between studies was assessed using Cochrane Q statistics and I-2 statistics. Results: A total of 54 studies (including six three-arm studies) involving 37,352 patients were included in the analysis. Insomnia was reported in 8.3% of subjects (95% confidence interval [CI] 8.0%-8.7%) treated with immunotherapy. Insomnia was significantly more common in patients receiving immunotherapy compared to those enrolled in study arms with inactive treatment (odds ratio [OR] 1.49, 95% CI 1.13-1.96). The odds for insomnia were similar between the arms for studies comparing CPI versus chemotherapy and CPI versus non-immunologic targeted therapies (OR 1.07, 95% CI 0.94-1.22 and OR 1.40, 95% CI 0.90-2.18, respectively). The OR for insomnia was higher for cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor inhibitors compared to the inhibitors of programmed death-1 (PD-1) receptor (OR 1.36, 95% CI 1.06 - 1.74). Conclusion: Cancer immunotherapy using CPI is associated with insomnia but the odds of developing the symptom are not greater with immunotherapy than with other systemic modalities including chemotherapy and non-immunologic targeted therapies.