Effects of Peroral Hormonal Contraception on Cardiovascular
System: Analysis of Selected Cardiovascular Parameters in an
Adolescent Cohort; a Pilot Project

J 2022

Effects of Peroral Hormonal Contraception on Cardiovascular System: Analysis of Selected Cardiovascular Parameters in an Adolescent Cohort; a Pilot Project

PÍREK, Ondřej, Xenie BUDÍNSKÁ a Zuzana NOVÁKOVÁ

Základní údaje

Originální název

Effects of Peroral Hormonal Contraception on Cardiovascular System: Analysis of Selected Cardiovascular Parameters in an Adolescent Cohort; a Pilot Project

Autoři

PÍREK, Ondřej (203 Česká republika, domácí), Xenie BUDÍNSKÁ (203 Česká republika, garant, domácí) a Zuzana NOVÁKOVÁ (203 Česká republika, domácí)

Vydání

Physiological Research, Praha, Akademie věd České republiky, 2022, 0862-8408

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.100

Kód RIV

RIV/00216224:14110/22:00128245

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.33549/physiolres.934997

UT WoS

000924861700005

Klíčová slova anglicky

Oral contraceptive pills; Arterial stiffness; Pulse wave velocity; Subendocardial viability index

Štítky

14110515, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 3. 2023 07:43, Mgr. Tereza Miškechová

Anotace

V originále

Oral contraceptive pills (OCPs) have some strong advantages over more traditional types of contraception, including their consistently high contraceptive effect as well as multiple additional positive side effects. OCPs went through decades of intense pharmaceutical development and current formulas are well optimized – however, a handful of their negative side effects remain, including some that affect cardiovascular system, for example higher risk of hypertension, venous thromboembolism and increased arterial stiffness. The gold standard for arterial stiffness assessment is currently applanation tonometry, a method that relies on arterial pulse wave velocity measurement (PWV). Another possible method for arterial stiffness measurement is the use of the VaSera device, which measures cardio-ankle vascular index (CAVI). The aim of this study was to discover the effect of OCPs use on selected cardiovascular parameters related to arterial stiffness. We measured these cardiovascular parameters in the OCPs using group (OCP) and in the control group (CTRL) using applanation tonometer Sphygmocor and the VaSera device. Comparison of the data from both groups showed us significantly increased diastolic blood pressure (DBP) and carotid-radial pulse wave velocity (crPWV) as well as significantly lower subendocardial viability index (SVI) in the OCP. These results imply a negative effect of hormonal contraceptives on the cardiovascular system with most of the negative changes affecting the peripheral arteries. Despite this evidence supporting the hypothesis of OCPs having a negative effect on cardiovascular health, further research is necessary.

Návaznosti

MUNI/A/1133/2021, interní kód MU

Název: Od buňky k medicíně (Akronym: CELLVIEW)

Investor: Masarykova univerzita, Od buňky k medicíně

Citovat

PÍREK, Ondřej, Xenie BUDÍNSKÁ a Zuzana NOVÁKOVÁ. Effects of Peroral Hormonal Contraception on Cardiovascular System: Analysis of Selected Cardiovascular Parameters in an Adolescent Cohort; a Pilot Project. Physiological Research. Praha: Akademie věd České republiky, 2022, roč. 71, Suppl. 2, s. "S203"-"S210", 8 s. ISSN 0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.934997.

@article{2249450,
   author = {Pírek, Ondřej and Budínská, Xenie and Nováková, Zuzana},
   article_location = {Praha},
   article_number = {Suppl. 2},
   doi = {http://dx.doi.org/10.33549/physiolres.934997},
   keywords = {Oral contraceptive pills; Arterial stiffness; Pulse wave velocity; Subendocardial viability index},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Effects of Peroral Hormonal Contraception on Cardiovascular System: Analysis of Selected Cardiovascular Parameters in an Adolescent Cohort; a Pilot Project},
   url = {https://www.biomed.cas.cz/physiolres/pdf/2022/71_S203.pdf},
   volume = {71},
   year = {2022}
}

TY  - JOUR
ID  - 2249450
AU  - Pírek, Ondřej - Budínská, Xenie - Nováková, Zuzana
PY  - 2022
TI  - Effects of Peroral Hormonal Contraception on Cardiovascular System: Analysis of Selected Cardiovascular Parameters in an Adolescent Cohort; a Pilot Project
JF  - Physiological Research
VL  - 71
IS  - Suppl. 2
SP  - "S203"-"S210"
EP  - "S203"-"S210"
PB  - Akademie věd České republiky
SN  - 08628408
KW  - Oral contraceptive pills
KW  - Arterial stiffness
KW  - Pulse wave velocity
KW  - Subendocardial viability index
UR  - https://www.biomed.cas.cz/physiolres/pdf/2022/71_S203.pdf
N2  - Oral contraceptive pills (OCPs) have some strong advantages over more traditional types of contraception, including their consistently high contraceptive effect as well as multiple additional positive side effects. OCPs went through decades of intense pharmaceutical development and current formulas are well optimized – however, a handful of their negative side effects remain, including some that affect cardiovascular system, for example higher risk of hypertension, venous thromboembolism and increased arterial stiffness. The gold standard for arterial stiffness assessment is currently applanation tonometry, a method that relies on arterial pulse wave velocity measurement (PWV). Another possible method for arterial stiffness measurement is the use of the VaSera device, which measures cardio-ankle vascular index (CAVI). The aim of this study was to discover the effect of OCPs use on selected cardiovascular parameters related to arterial stiffness. We measured these cardiovascular parameters in the OCPs using group (OCP) and in the control group (CTRL) using applanation tonometer Sphygmocor and the VaSera device. Comparison of the data from both groups showed us significantly increased diastolic blood pressure (DBP) and carotid-radial pulse wave velocity (crPWV) as well as significantly lower subendocardial viability index (SVI) in the OCP. These results imply a negative effect of hormonal contraceptives on the cardiovascular system with most of the negative changes affecting the peripheral arteries. Despite this evidence supporting the hypothesis of OCPs having a negative effect on cardiovascular health, further research is necessary.
ER  -

PÍREK, Ondřej, Xenie BUDÍNSKÁ a Zuzana NOVÁKOVÁ. Effects of Peroral Hormonal Contraception on Cardiovascular System: Analysis of Selected Cardiovascular Parameters in an Adolescent Cohort; a Pilot Project. \textit{Physiological Research}. Praha: Akademie věd České republiky, 2022, roč.~71, Suppl. 2, s.~''S203''-''S210'', 8 s. ISSN~0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.934997.

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