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@article{2249569,
author = {Kincl, Vladimír and Panovský, Roman and Kepák, Tomáš and Bajčiová, Viera and Bednárová, Veronika and Opatřil, Lukáš and Máchal, Jan},
article_location = {HOBOKEN},
article_number = {8},
doi = {http://dx.doi.org/10.1002/cam4.4564},
keywords = {late cardiotoxic effects; cancer in childhood},
language = {eng},
issn = {2045-7634},
journal = {Cancer Medicine},
title = {Assessment of late cardiotoxic effects in patients treated for cancer in childhood},
url = {https://onlinelibrary.wiley.com/doi/10.1002/cam4.4564},
volume = {11},
year = {2022}
}
TY - JOUR
ID - 2249569
AU - Kincl, Vladimír - Panovský, Roman - Kepák, Tomáš - Bajčiová, Viera - Bednárová, Veronika - Opatřil, Lukáš - Máchal, Jan
PY - 2022
TI - Assessment of late cardiotoxic effects in patients treated for cancer in childhood
JF - Cancer Medicine
VL - 11
IS - 8
SP - 1763-1768
EP - 1763-1768
PB - John Wiley & Sons Ltd.
SN - 20457634
KW - late cardiotoxic effects
KW - cancer in childhood
UR - https://onlinelibrary.wiley.com/doi/10.1002/cam4.4564
N2 - Background: The most frequent chemotherapeutic regimens used in children's cancer contain anthracyclines, which may have potentially cardiotoxic effects even at a later point in time. Echocardiography including tissue Doppler imaging is well-proved noninvasive method to assess cardiac function. Objectives: To assess the late cardiotoxic effects in young adults treated for various cancer types in childhood. Methods: Ninety-eight young adults who were treated for childhood cancer (CCS), median time 12.1 years after finishing the therapy, were comprised into study. All subjects underwent echocardiographic examination including tissue Doppler imaging. The echocardiographic parameters were compared to 57 healthy age-matched subjects. The CCS group also underwent 24-h ECG Holter monitoring to reveal any arrhythmias. Results: The subjects in CCS group had lower E' velocities from lateral (15.6 vs. 17.6 cm/s) and septal part (12.2 vs. 14.4 cm/s) of mitral annulus (p for both <0.001) and also lower S' velocity from the tricuspid annulus (12.4. vs. 13.3 cm/s, p = 0.013) and tricuspid annulus peak systolic excursion (TAPSE; 22.2 vs. 23.9 mm, p = 0.017). There were no significant differences in left ventricular systolic velocities or ejection fraction. The occurrence of arrhythmias did not differ among subgroups of CCS with or without anthracycline therapy. Conclusion: Childhood cancer survivors had subclinical cardiac impairment in comparison with healthy controls, particularly in left ventricular diastolic function.
ER -
KINCL, Vladimír, Roman PANOVSKÝ, Tomáš KEPÁK, Viera BAJČIOVÁ, Veronika BEDNÁROVÁ, Lukáš OPATŘIL and Jan MÁCHAL. Assessment of late cardiotoxic effects in patients treated for cancer in childhood. \textit{Cancer Medicine}. HOBOKEN: John Wiley \&{} Sons Ltd., 2022, vol.~11, No~8, p.~1763-1768. ISSN~2045-7634. Available from: https://dx.doi.org/10.1002/cam4.4564.
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