Myocardial injury in stress echocardiography: Comparison of
dobutamine, dipyridamole and dynamic stressors-single center
study

J 2022

Myocardial injury in stress echocardiography: Comparison of dobutamine, dipyridamole and dynamic stressors-single center study

MEDILEK, Karel, Lenka ZALOUDKOVA, Alexander BORG, Lucie KUBÍNOVÁ, Josef STASEK et. al.

Základní údaje

Originální název

Myocardial injury in stress echocardiography: Comparison of dobutamine, dipyridamole and dynamic stressors-single center study

Autoři

MEDILEK, Karel (203 Česká republika, garant), Lenka ZALOUDKOVA (203 Česká republika), Alexander BORG, Lucie KUBÍNOVÁ (203 Česká republika, domácí) a Josef STASEK (203 Česká republika)

Vydání

Echocardiography - A Journal of Cardiovascular Ultrasound and Allied Techniques, HOBOKEN, WILEY, 2022, 0742-2822

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.500

Kód RIV

RIV/00216224:14110/22:00128278

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/echo.15411

UT WoS

000838624800001

Klíčová slova anglicky

negative stress echocardiography; myocardial injury; hsTnT

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 1. 2023 14:06, Mgr. Tereza Miškechová

Anotace

V originále

Objectives: In stress echocardiography (SE), dipyridamole (DIP) and dynamic stress (ExSE) are reported as being safer than dobutamine stress echocardiography (DSE). We investigated whether these commonly used stressors cause myocardial injury, measured by high sensitivity troponin T (hsTnT). Methods: One hundred and thirty five patients (DSE n = 46, ExsE n = 46, DIP n = 43) with negative result of SE were studied. The exclusion criteria were known ischaemic heart disease (IHD), baseline wall motion abnormalities, left ventricle systolic dysfunction/regional wall motion abnormalities, septum/posterior wall >= 13 mm, diabetes/pre-diabetes, baseline hsTnT level >= 14 ng/L, baseline blood pressure >= 160/100 mmHg, peak pulmonary pressure >= 45mmHg, eGFR <1ml/s/1.73m(2), more than mild to moderate valvular disease and dobutamine side effects. HsTnT was measured before and 180 minutes after the test. Results: All patients had low pre-test probabilities of having obstructive IHD. HsTnT increased in DSE, less so in ExSE, and was unchanged in the DIP group (Delta hsTnT 9.4 [1.5-58.6], 1.1 [-0.9-15.7], -0.1 [-1.4-2.1] ng/L, respectively, p<0.001). In DSE, the Delta hsTnT was associated with peak dobutamine dose (r = 0.30, p = 0.045), test length (r = 0.43, p = 0.003) and atropine use (p<0.001). In ExSE, the hsTnT increase was more likely in females (p = 0.012) and the elderly (>65 years) (r = 0.32, p = 0.03); no association was found between atropine use (p = 0.786) or test length and AhsTnT (r = 0.10, p = 0.530). Conclusions: DSE is associated with myocardial injury in patients with negative SE, no injury was observed in DIP and only mild case in ExSE. Whether myocardial injury is causative of the higher reported adverse event rates in DSE remains to be determined.

Citovat

MEDILEK, Karel, Lenka ZALOUDKOVA, Alexander BORG, Lucie KUBÍNOVÁ a Josef STASEK. Myocardial injury in stress echocardiography: Comparison of dobutamine, dipyridamole and dynamic stressors-single center study. Echocardiography - A Journal of Cardiovascular Ultrasound and Allied Techniques. HOBOKEN: WILEY, 2022, roč. 39, č. 9, s. 1171-1179. ISSN 0742-2822. Dostupné z: https://dx.doi.org/10.1111/echo.15411.

@article{2249628,
   author = {Medilek, Karel and Zaloudkova, Lenka and Borg, Alexander and Kubínová, Lucie and Stasek, Josef},
   article_location = {HOBOKEN},
   article_number = {9},
   doi = {http://dx.doi.org/10.1111/echo.15411},
   keywords = {negative stress echocardiography; myocardial injury; hsTnT},
   language = {eng},
   issn = {0742-2822},
   journal = {Echocardiography - A Journal of Cardiovascular Ultrasound and Allied Techniques},
   title = {Myocardial injury in stress echocardiography: Comparison of dobutamine, dipyridamole and dynamic stressors-single center study},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/echo.15411},
   volume = {39},
   year = {2022}
}

TY  - JOUR
ID  - 2249628
AU  - Medilek, Karel - Zaloudkova, Lenka - Borg, Alexander - Kubínová, Lucie - Stasek, Josef
PY  - 2022
TI  - Myocardial injury in stress echocardiography: Comparison of dobutamine, dipyridamole and dynamic stressors-single center study
JF  - Echocardiography - A Journal of Cardiovascular Ultrasound and Allied Techniques
VL  - 39
IS  - 9
SP  - 1171-1179
EP  - 1171-1179
PB  - WILEY
SN  - 07422822
KW  - negative stress echocardiography
KW  - myocardial injury
KW  - hsTnT
UR  - https://onlinelibrary.wiley.com/doi/10.1111/echo.15411
N2  - Objectives: In stress echocardiography (SE), dipyridamole (DIP) and dynamic stress (ExSE) are reported as being safer than dobutamine stress echocardiography (DSE). We investigated whether these commonly used stressors cause myocardial injury, measured by high sensitivity troponin T (hsTnT). Methods: One hundred and thirty five patients (DSE n = 46, ExsE n = 46, DIP n = 43) with negative result of SE were studied. The exclusion criteria were known ischaemic heart disease (IHD), baseline wall motion abnormalities, left ventricle systolic dysfunction/regional wall motion abnormalities, septum/posterior wall >= 13 mm, diabetes/pre-diabetes, baseline hsTnT level >= 14 ng/L, baseline blood pressure >= 160/100 mmHg, peak pulmonary pressure >= 45mmHg, eGFR <1ml/s/1.73m(2), more than mild to moderate valvular disease and dobutamine side effects. HsTnT was measured before and 180 minutes after the test. Results: All patients had low pre-test probabilities of having obstructive IHD. HsTnT increased in DSE, less so in ExSE, and was unchanged in the DIP group (Delta hsTnT 9.4 [1.5-58.6], 1.1 [-0.9-15.7], -0.1 [-1.4-2.1] ng/L, respectively, p<0.001). In DSE, the Delta hsTnT was associated with peak dobutamine dose (r = 0.30, p = 0.045), test length (r = 0.43, p = 0.003) and atropine use (p<0.001). In ExSE, the hsTnT increase was more likely in females (p = 0.012) and the elderly (>65 years) (r = 0.32, p = 0.03); no association was found between atropine use (p = 0.786) or test length and AhsTnT (r = 0.10, p = 0.530). Conclusions: DSE is associated with myocardial injury in patients with negative SE, no injury was observed in DIP and only mild case in ExSE. Whether myocardial injury is causative of the higher reported adverse event rates in DSE remains to be determined.
ER  -

MEDILEK, Karel, Lenka ZALOUDKOVA, Alexander BORG, Lucie KUBÍNOVÁ a Josef STASEK. Myocardial injury in stress echocardiography: Comparison of dobutamine, dipyridamole and dynamic stressors-single center study. \textit{Echocardiography - A Journal of Cardiovascular Ultrasound and Allied Techniques}. HOBOKEN: WILEY, 2022, roč.~39, č.~9, s.~1171-1179. ISSN~0742-2822. Dostupné z: https://dx.doi.org/10.1111/echo.15411.

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