The Significance of MicroRNAs in the Molecular Pathology of
Brain Metastases

J 2022

The Significance of MicroRNAs in the Molecular Pathology of Brain Metastases

SIEGL, František, Marek VEČEŘA, Ivana ROŠKOVÁ, Martin SMRČKA, Radim JANČÁLEK et. al.

Základní údaje

Originální název

The Significance of MicroRNAs in the Molecular Pathology of Brain Metastases

Autoři

SIEGL, František (203 Česká republika, domácí), Marek VEČEŘA (703 Slovensko, domácí), Ivana ROŠKOVÁ (703 Slovensko, domácí), Martin SMRČKA (203 Česká republika, domácí), Radim JANČÁLEK (203 Česká republika, domácí), Tomáš KAZDA (203 Česká republika, domácí), Ondřej SLABÝ (203 Česká republika, domácí) a Jiří ŠÁNA (203 Česká republika, garant, domácí)

Vydání

Cancers, Basel, MDPI, 2022, 2072-6694

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.200

Kód RIV

RIV/00216224:14740/22:00129731

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.3390/cancers14143386

UT WoS

000832241700001

Klíčová slova anglicky

brain metastases; microRNA; metastatic cascade; biomarkers

Štítky

14110131, 14110224, 14110513, 14110811, 14110812, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 2. 2023 20:42, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Simple Summary Brain metastases are increasingly common in cancer patients and hurt survival and quality of life. Therefore, efforts are increasingly devoted to research into brain metastases and discovering new diagnostic approaches and therapeutic targets. MicroRNAs, which are involved in regulating most cellular processes, including metastasis, appear to be promising molecules in this regard. The number of studies on microRNAs is constantly increasing. This review aims to summarize the current knowledge on the importance of microRNAs in the pathobiology of brain metastases and to suggest possibilities for their use in diagnostic and therapeutic practice. Brain metastases are the most frequent intracranial tumors in adults and the cause of death in almost one-fourth of cases. The incidence of brain metastases is steadily increasing. The main reason for this increase could be the introduction of new and more efficient therapeutic strategies that lead to longer survival but, at the same time, cause a higher risk of brain parenchyma infiltration. In addition, the advances in imaging methodology, which provide earlier identification of brain metastases, may also be a reason for the higher recorded number of patients with these tumors. Metastasis is a complex biological process that is still largely unexplored, influenced by many factors and involving many molecules. A deeper understanding of the process will allow the discovery of more effective diagnostic and therapeutic approaches that could improve the quality and length of patient survival. Recent studies have shown that microRNAs (miRNAs) are essential molecules that are involved in specific steps of the metastatic cascade. MiRNAs are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression and thus regulate most cellular processes. The dysregulation of these molecules has been implicated in many cancers, including brain metastases. Therefore, miRNAs represent promising diagnostic molecules and therapeutic targets in brain metastases. This review summarizes the current knowledge on the importance of miRNAs in brain metastasis, focusing on their involvement in the metastatic cascade and their potential clinical implications.

Návaznosti

NV18-03-00398, projekt VaV

Název: Rozšíření současných prognostických skórovacích systémů u mozkových metastáz o mikroRNA profilování s cílem individualizace pooperační péče

Investor: Ministerstvo zdravotnictví ČR, Rozšíření současných prognostických skórovacích systémů u mozkových metastáz o mikroRNA profilování s cílem individualizace pooperační péče

Citovat

SIEGL, František, Marek VEČEŘA, Ivana ROŠKOVÁ, Martin SMRČKA, Radim JANČÁLEK, Tomáš KAZDA, Ondřej SLABÝ a Jiří ŠÁNA. The Significance of MicroRNAs in the Molecular Pathology of Brain Metastases. Cancers. Basel: MDPI, 2022, roč. 14, č. 14, s. 1-23. ISSN 2072-6694. Dostupné z: https://dx.doi.org/10.3390/cancers14143386.

@article{2249822,
   author = {Siegl, František and Večeřa, Marek and Rošková, Ivana and Smrčka, Martin and Jančálek, Radim and Kazda, Tomáš and Slabý, Ondřej and Šána, Jiří},
   article_location = {Basel},
   article_number = {14},
   doi = {http://dx.doi.org/10.3390/cancers14143386},
   keywords = {brain metastases; microRNA; metastatic cascade; biomarkers},
   language = {eng},
   issn = {2072-6694},
   journal = {Cancers},
   title = {The Significance of MicroRNAs in the Molecular Pathology of Brain Metastases},
   url = {https://www.mdpi.com/2072-6694/14/14/3386},
   volume = {14},
   year = {2022}
}

TY  - JOUR
ID  - 2249822
AU  - Siegl, František - Večeřa, Marek - Rošková, Ivana - Smrčka, Martin - Jančálek, Radim - Kazda, Tomáš - Slabý, Ondřej - Šána, Jiří
PY  - 2022
TI  - The Significance of MicroRNAs in the Molecular Pathology of Brain Metastases
JF  - Cancers
VL  - 14
IS  - 14
SP  - 1-23
EP  - 1-23
PB  - MDPI
SN  - 20726694
KW  - brain metastases
KW  - microRNA
KW  - metastatic cascade
KW  - biomarkers
UR  - https://www.mdpi.com/2072-6694/14/14/3386
N2  - Simple Summary Brain metastases are increasingly common in cancer patients and hurt survival and quality of life. Therefore, efforts are increasingly devoted to research into brain metastases and discovering new diagnostic approaches and therapeutic targets. MicroRNAs, which are involved in regulating most cellular processes, including metastasis, appear to be promising molecules in this regard. The number of studies on microRNAs is constantly increasing. This review aims to summarize the current knowledge on the importance of microRNAs in the pathobiology of brain metastases and to suggest possibilities for their use in diagnostic and therapeutic practice. Brain metastases are the most frequent intracranial tumors in adults and the cause of death in almost one-fourth of cases. The incidence of brain metastases is steadily increasing. The main reason for this increase could be the introduction of new and more efficient therapeutic strategies that lead to longer survival but, at the same time, cause a higher risk of brain parenchyma infiltration. In addition, the advances in imaging methodology, which provide earlier identification of brain metastases, may also be a reason for the higher recorded number of patients with these tumors. Metastasis is a complex biological process that is still largely unexplored, influenced by many factors and involving many molecules. A deeper understanding of the process will allow the discovery of more effective diagnostic and therapeutic approaches that could improve the quality and length of patient survival. Recent studies have shown that microRNAs (miRNAs) are essential molecules that are involved in specific steps of the metastatic cascade. MiRNAs are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression and thus regulate most cellular processes. The dysregulation of these molecules has been implicated in many cancers, including brain metastases. Therefore, miRNAs represent promising diagnostic molecules and therapeutic targets in brain metastases. This review summarizes the current knowledge on the importance of miRNAs in brain metastasis, focusing on their involvement in the metastatic cascade and their potential clinical implications.
ER  -

SIEGL, František, Marek VEČEŘA, Ivana ROŠKOVÁ, Martin SMRČKA, Radim JANČÁLEK, Tomáš KAZDA, Ondřej SLABÝ a Jiří ŠÁNA. The Significance of MicroRNAs in the Molecular Pathology of Brain Metastases. \textit{Cancers}. Basel: MDPI, 2022, roč.~14, č.~14, s.~1-23. ISSN~2072-6694. Dostupné z: https://dx.doi.org/10.3390/cancers14143386.

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