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@article{2250035,
author = {Ilaria, Del Principe Maria and Seidel, Danila and Criscuolo, Marianna and Dargenio, Michelina and Ráčil, Zdeněk and Piedimonte, Monica and Marchesi, Francesco and Nadali, Gianpaolo and Koehler, Philipp and Fracchiolla, Nicola and Cattaneo, Chiara and Klimko, Nikolai and Spolzino, Angelica and Karapinar, Deniz Yilmaz and Demiraslan, Hayati and Duarte, Rafael F and Demeter, Judit and Stanzani, Marta and Melillo, Lorella Maria Antonia and Basilico, Claudia Maria and Cesaro, Simone and Paterno, Giovangiacinto and Califano, Catello and Delia, Mario and Buzzatti, Elisa and Busca, Alessandro and Cornely, Oliver A and Pagano, Livio and Alakel, Nael and Arsenijevi'c, Valentina Arsi and Camus, Vincent and FalcesandRomero, Iker and Itzhak, Levy and Kouba, Michal and Martino, Rodrigo and Sedlacek, Petr and Weinbergerová, Barbora},
article_location = {Hoboken},
article_number = {1},
doi = {http://dx.doi.org/10.1111/myc.13524},
keywords = {antifungal treatment; Candidemia; fungal infection; Geotrichum; Magnusiomyces; Saprochaete},
language = {eng},
issn = {0933-7407},
journal = {Mycoses},
title = {Clinical features and prognostic factors of Magnusiomyces (Saprochaete) infections in haematology. A multicentre study of SEIFEM/Fungiscope},
url = {https://onlinelibrary.wiley.com/doi/10.1111/myc.13524},
volume = {66},
year = {2023}
}
TY - JOUR
ID - 2250035
AU - Ilaria, Del Principe Maria - Seidel, Danila - Criscuolo, Marianna - Dargenio, Michelina - Ráčil, Zdeněk - Piedimonte, Monica - Marchesi, Francesco - Nadali, Gianpaolo - Koehler, Philipp - Fracchiolla, Nicola - Cattaneo, Chiara - Klimko, Nikolai - Spolzino, Angelica - Karapinar, Deniz Yilmaz - Demiraslan, Hayati - Duarte, Rafael F - Demeter, Judit - Stanzani, Marta - Melillo, Lorella Maria Antonia - Basilico, Claudia Maria - Cesaro, Simone - Paterno, Giovangiacinto - Califano, Catello - Delia, Mario - Buzzatti, Elisa - Busca, Alessandro - Cornely, Oliver A - Pagano, Livio - Alakel, Nael - Arsenijevi'c, Valentina Arsi - Camus, Vincent - Falces-Romero, Iker - Itzhak, Levy - Kouba, Michal - Martino, Rodrigo - Sedlacek, Petr - Weinbergerová, Barbora
PY - 2023
TI - Clinical features and prognostic factors of Magnusiomyces (Saprochaete) infections in haematology. A multicentre study of SEIFEM/Fungiscope
JF - Mycoses
VL - 66
IS - 1
SP - 35-46
EP - 35-46
PB - Wiley-Blackwell
SN - 09337407
KW - antifungal treatment
KW - Candidemia
KW - fungal infection
KW - Geotrichum
KW - Magnusiomyces
KW - Saprochaete
UR - https://onlinelibrary.wiley.com/doi/10.1111/myc.13524
N2 - Background Our multicentre study aims to identify baseline factors and provide guidance for therapeutic decisions regarding Magnusiomyces-associated infections, an emerging threat in patients with haematological malignancies. Methods HM patients with proven (Magnusiomyces capitatus) M. capitatus or (Magnusiomyces clavatus) M. clavatus (formerly Saprochaete capitata and Saprochaete clavata) infection diagnosed between January 2010 and December 2020 were recorded from the SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group and FungiScope (Global Emerging Fungal Infection Registry). Cases of Magnusiomyces fungemia were compared with candidemia. Results Among 90 Magnusiomyces cases (60 [66%] M. capitatus and 30 (34%) M. clavatus), median age was 50 years (range 2-78), 46 patients (51%) were female and 67 (74%) had acute leukaemia. Thirty-six (40%) of Magnusiomyces-associated infections occurred during antifungal prophylaxis, mainly with posaconazole (n = 13, 36%) and echinocandins (n = 12, 34%). Instead, the candidemia rarely occurred during prophylaxis (p < .0001). First-line antifungal therapy with azoles, alone or in combination, was associated with improved response compared to other antifungals (p = .001). Overall day-30 mortality rate was 43%. Factors associated with higher mortality rates were septic shock (HR 2.696, 95% CI 1.396-5.204, p = .003), corticosteroid treatment longer than 14 days (HR 2.245, 95% CI 1.151-4.376, p = .018) and lack of neutrophil recovery (HR 3.997, 95% CI 2.102-7.601, p < .001). The latter was independently associated with poor outcome (HR 2.495, 95% CI 1.192-5.222, p = .015). Conclusions Magnusiomyces-associated infections are often breakthrough infections. Effective treatment regimens of these infections remain to be determined, but neutrophil recovery appears to play an important role in the favourable outcome.
ER -
ILARIA, Del Principe Maria, Danila SEIDEL, Marianna CRISCUOLO, Michelina DARGENIO, Zdeněk RÁČIL, Monica PIEDIMONTE, Francesco MARCHESI, Gianpaolo NADALI, Philipp KOEHLER, Nicola FRACCHIOLLA, Chiara CATTANEO, Nikolai KLIMKO, Angelica SPOLZINO, Deniz Yilmaz KARAPINAR, Hayati DEMIRASLAN, Rafael F DUARTE, Judit DEMETER, Marta STANZANI, Lorella Maria Antonia MELILLO, Claudia Maria BASILICO, Simone CESARO, Giovangiacinto PATERNO, Catello CALIFANO, Mario DELIA, Elisa BUZZATTI, Alessandro BUSCA, Oliver A CORNELY, Livio PAGANO, Nael ALAKEL, Valentina Arsi ARSENIJEVI'C, Vincent CAMUS, Iker FALCES-ROMERO, Levy ITZHAK, Michal KOUBA, Rodrigo MARTINO, Petr SEDLACEK a Barbora WEINBERGEROVÁ. Clinical features and prognostic factors of Magnusiomyces (Saprochaete) infections in haematology. A multicentre study of SEIFEM/Fungiscope. \textit{Mycoses}. Hoboken: Wiley-Blackwell, 2023, roč.~66, č.~1, s.~35-46. ISSN~0933-7407. Dostupné z: https://dx.doi.org/10.1111/myc.13524.
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