Some New Aspects of Genetic Variability in Patients with
Cutaneous T-Cell Lymphoma

J 2022

Some New Aspects of Genetic Variability in Patients with Cutaneous T-Cell Lymphoma

VAŠKŮ, Vladimír, Jan MÁCHAL, Filip ZLÁMAL a Anna VAŠKŮ

Základní údaje

Originální název

Some New Aspects of Genetic Variability in Patients with Cutaneous T-Cell Lymphoma

Autoři

VAŠKŮ, Vladimír (203 Česká republika, domácí), Jan MÁCHAL (203 Česká republika, domácí), Filip ZLÁMAL (203 Česká republika) a Anna VAŠKŮ (203 Česká republika, garant, domácí)

Vydání

Genes, BASEL, MDPI, 2022, 2073-4425

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30109 Pathology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.500

Kód RIV

RIV/00216224:14110/22:00128334

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/genes13122401

UT WoS

000902532500001

Klíčová slova anglicky

skin T-cell lymphoma; mycosis fungoides; CTCL; polymorphism-MDR1

Štítky

14110125, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 1. 2023 14:08, Mgr. Tereza Miškechová

Anotace

V originále

Aim: Cutaneous T-cell lymphoma (CTCL) is a group of T-cell malignancies that develop in the skin. Though studied intensively, the etiology and pathogenesis of CTCL remain elusive. This study evaluated the survival of CTCL patients in the 1st Department of Dermatovenereology of St. Anne's University Hospital Brno. It included analysis of 19 polymorphic gene variants based on their expected involvement in CTCL severity. Material and methods: 75 patients with CTCL, evaluated and treated at the 1st Department of Dermatovenereology of St. Anne ' s University Hospital Brno, Faculty of Medicine, Masaryk University, were recruited for the study over the last 28 years (44 men and 31 women, average age 58 years, range 20-82 years). All patients were genotyped for 19 chosen gene polymorphisms by the conventional PCR method with restriction analysis. A multivariate Cox regression model was calculated to reveal genetic polymorphisms and other risk factors for survival. Results: The model identified MDR Ex21 2677 (rs2032582) as a significant genetic factor influencing the survival of the patients, with the T-allele playing a protective role. A multivariate stepwise Cox regression model confirmed the following as significant independent risk factors for overall survival: increased age at admission, clinical staging of the tumor, and male sex. Conclusion: We showed that the TT genotype at position 2677 of the MDR1 gene exhibited statistically significant longer survival in CTCL patients. As such, the TT genotype of MDR1 confers a significant advantage for the CTCL patients who respond to treatment.

Citovat

VAŠKŮ, Vladimír, Jan MÁCHAL, Filip ZLÁMAL a Anna VAŠKŮ. Some New Aspects of Genetic Variability in Patients with Cutaneous T-Cell Lymphoma. Genes. BASEL: MDPI, 2022, roč. 13, č. 12, s. 1-7. ISSN 2073-4425. Dostupné z: https://dx.doi.org/10.3390/genes13122401.

@article{2250089,
   author = {Vašků, Vladimír and Máchal, Jan and Zlámal, Filip and Vašků, Anna},
   article_location = {BASEL},
   article_number = {12},
   doi = {http://dx.doi.org/10.3390/genes13122401},
   keywords = {skin T-cell lymphoma; mycosis fungoides; CTCL; polymorphism-MDR1},
   language = {eng},
   issn = {2073-4425},
   journal = {Genes},
   title = {Some New Aspects of Genetic Variability in Patients with Cutaneous T-Cell Lymphoma},
   url = {https://www.mdpi.com/2073-4425/13/12/2401},
   volume = {13},
   year = {2022}
}

TY  - JOUR
ID  - 2250089
AU  - Vašků, Vladimír - Máchal, Jan - Zlámal, Filip - Vašků, Anna
PY  - 2022
TI  - Some New Aspects of Genetic Variability in Patients with Cutaneous T-Cell Lymphoma
JF  - Genes
VL  - 13
IS  - 12
SP  - 1-7
EP  - 1-7
PB  - MDPI
SN  - 20734425
KW  - skin T-cell lymphoma
KW  - mycosis fungoides
KW  - CTCL
KW  - polymorphism-MDR1
UR  - https://www.mdpi.com/2073-4425/13/12/2401
N2  - Aim: Cutaneous T-cell lymphoma (CTCL) is a group of T-cell malignancies that develop in the skin. Though studied intensively, the etiology and pathogenesis of CTCL remain elusive. This study evaluated the survival of CTCL patients in the 1st Department of Dermatovenereology of St. Anne's University Hospital Brno. It included analysis of 19 polymorphic gene variants based on their expected involvement in CTCL severity. Material and methods: 75 patients with CTCL, evaluated and treated at the 1st Department of Dermatovenereology of St. Anne ' s University Hospital Brno, Faculty of Medicine, Masaryk University, were recruited for the study over the last 28 years (44 men and 31 women, average age 58 years, range 20-82 years). All patients were genotyped for 19 chosen gene polymorphisms by the conventional PCR method with restriction analysis. A multivariate Cox regression model was calculated to reveal genetic polymorphisms and other risk factors for survival. Results: The model identified MDR Ex21 2677 (rs2032582) as a significant genetic factor influencing the survival of the patients, with the T-allele playing a protective role. A multivariate stepwise Cox regression model confirmed the following as significant independent risk factors for overall survival: increased age at admission, clinical staging of the tumor, and male sex. Conclusion: We showed that the TT genotype at position 2677 of the MDR1 gene exhibited statistically significant longer survival in CTCL patients. As such, the TT genotype of MDR1 confers a significant advantage for the CTCL patients who respond to treatment.
ER  -

VAŠKŮ, Vladimír, Jan MÁCHAL, Filip ZLÁMAL a Anna VAŠKŮ. Some New Aspects of Genetic Variability in Patients with Cutaneous T-Cell Lymphoma. \textit{Genes}. BASEL: MDPI, 2022, roč.~13, č.~12, s.~1-7. ISSN~2073-4425. Dostupné z: https://dx.doi.org/10.3390/genes13122401.

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