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@article{2251385,
author = {Micale, Vincenzo and Martina, Di Bartolomeo and Serena, Di Martino and Štark, Tibor and Dell'Osso, Bernardo and Drago, Filippo and Addario, Claudio},
article_location = {OXFORD},
article_number = {January 2023},
doi = {http://dx.doi.org/10.1016/j.pharmthera.2022.108279},
keywords = {Schizophrenia; Bipolar disorder; Depression; DNA methylation; Epigenetics; Antidepressants; Antipsychotics},
language = {eng},
issn = {0163-7258},
journal = {PHARMACOLOGY & THERAPEUTICS},
title = {Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets},
url = {https://www.sciencedirect.com/science/article/pii/S0163725822001735?via%3Dihub},
volume = {241},
year = {2023}
}
TY - JOUR
ID - 2251385
AU - Micale, Vincenzo - Martina, Di Bartolomeo - Serena, Di Martino - Štark, Tibor - Dell'Osso, Bernardo - Drago, Filippo - Addario, Claudio
PY - 2023
TI - Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets
JF - PHARMACOLOGY & THERAPEUTICS
VL - 241
IS - January 2023
SP - 1-39
EP - 1-39
PB - PERGAMON-ELSEVIER SCIENCE LTD
SN - 01637258
KW - Schizophrenia
KW - Bipolar disorder
KW - Depression
KW - DNA methylation
KW - Epigenetics
KW - Antidepressants
KW - Antipsychotics
UR - https://www.sciencedirect.com/science/article/pii/S0163725822001735?via%3Dihub
N2 - The etiopathogenesis of mental disorders is not fully understood and accumulating evidence support that clinical symptomatology cannot be assigned to a single gene mutation, but it involves several genetic factors. More specifically, a tight association between genes and environmental risk factors, which could be mediated by epigenetic mechanisms, may play a role in the development of mental disorders. Several data suggest that epigenetic modifications such as DNA methylation, post-translational histone modification and interference of microRNA (miRNA) or long non-coding RNA (lncRNA) may modify the severity of the disease and the outcome of the therapy. Indeed, the study of these mechanisms may help to identify patients particularly vulnerable to mental disorders and may have potential utility as biomarkers to facilitate diagnosis and treatment of psychiatric disorders. This article summarizes the most relevant preclinical and human data showing how epigenetic modifications can be central to the therapeutic efficacy of antidepressant and/or antipsychotic agents, as possible predictor of drugs response.
ER -
MICALE, Vincenzo, Di Bartolomeo MARTINA, Di Martino SERENA, Tibor ŠTARK, Bernardo DELL'OSSO, Filippo DRAGO and Claudio ADDARIO. Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets. \textit{PHARMACOLOGY \&{} THERAPEUTICS}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2023, vol.~241, January 2023, p.~1-39. ISSN~0163-7258. Available from: https://dx.doi.org/10.1016/j.pharmthera.2022.108279.
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