Commercially Available Enteric Empty Hard Capsules, Production
Technology and Application

J 2022

Commercially Available Enteric Empty Hard Capsules, Production Technology and Application

FRANC, Aleš, David VETCHÝ a Nicole FÜLÖPOVÁ

Základní údaje

Originální název

Commercially Available Enteric Empty Hard Capsules, Production Technology and Application

Autoři

FRANC, Aleš (203 Česká republika, domácí), David VETCHÝ (203 Česká republika, domácí) a Nicole FÜLÖPOVÁ (703 Slovensko, garant, domácí)

Vydání

Pharmaceuticals, BASEL, MDPI, 2022, 1424-8247

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.600

Kód RIV

RIV/00216224:14160/22:00128472

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.3390/ph15111398

UT WoS

000910840300001

Klíčová slova anglicky

hard capsules; commercial capsules; enteric administration; acid resistance; encapsulation; ECDDT technology

Štítky

rivok, ÚFT

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 2. 2023 11:13, JUDr. Sabina Krejčiříková

Anotace

V originále

Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics or fecal material, in the fecal microbiota transplantation (FMT) process. A suitable method seems to be the encapsulation of drugs or lyophilized alternatively frozen biological suspensions in commercial hard enteric capsules prepared by so-called Enteric Capsule Drug Delivery Technology (ECDDT). Manufacturers supply these types of capsules, made from pH-soluble polymers, in products such as AR Caps®, EnTRinsicTM, and Vcaps® Enteric, or capsules made of gelling polymers that release their content as the gel erodes over time when passing through the digestive tract. These include DRcaps®, EMBO CAPS® AP, BioVXR®, or ACGcaps™ HD. Although not all capsules in all formulations meet pharmaceutical requirements for delayed-release dosage forms in disintegration and dissolution tests, they usually find practical application. This literature review presents their composition and properties. Since ECDDT is a new technology, this article is based on a limited number of references.

Citovat

FRANC, Aleš, David VETCHÝ a Nicole FÜLÖPOVÁ. Commercially Available Enteric Empty Hard Capsules, Production Technology and Application. Pharmaceuticals. BASEL: MDPI, 2022, roč. 15, č. 11, s. 1-19. ISSN 1424-8247. Dostupné z: https://dx.doi.org/10.3390/ph15111398.

@article{2251896,
   author = {Franc, Aleš and Vetchý, David and Fülöpová, Nicole},
   article_location = {BASEL},
   article_number = {11},
   doi = {http://dx.doi.org/10.3390/ph15111398},
   keywords = {hard capsules; commercial capsules; enteric administration; acid resistance; encapsulation; ECDDT technology},
   language = {eng},
   issn = {1424-8247},
   journal = {Pharmaceuticals},
   title = {Commercially Available Enteric Empty Hard Capsules, Production Technology and Application},
   url = {https://www.mdpi.com/1424-8247/15/11/1398},
   volume = {15},
   year = {2022}
}

TY  - JOUR
ID  - 2251896
AU  - Franc, Aleš - Vetchý, David - Fülöpová, Nicole
PY  - 2022
TI  - Commercially Available Enteric Empty Hard Capsules, Production Technology and Application
JF  - Pharmaceuticals
VL  - 15
IS  - 11
SP  - 1-19
EP  - 1-19
PB  - MDPI
SN  - 14248247
KW  - hard capsules
KW  - commercial capsules
KW  - enteric administration
KW  - acid resistance
KW  - encapsulation
KW  - ECDDT technology
UR  - https://www.mdpi.com/1424-8247/15/11/1398
N2  - Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics or fecal material, in the fecal microbiota transplantation (FMT) process. A suitable method seems to be the encapsulation of drugs or lyophilized alternatively frozen biological suspensions in commercial hard enteric capsules prepared by so-called Enteric Capsule Drug Delivery Technology (ECDDT). Manufacturers supply these types of capsules, made from pH-soluble polymers, in products such as AR Caps®, EnTRinsicTM, and Vcaps® Enteric, or capsules made of gelling polymers that release their content as the gel erodes over time when passing through the digestive tract. These include DRcaps®, EMBO CAPS® AP, BioVXR®, or ACGcaps™ HD. Although not all capsules in all formulations meet pharmaceutical requirements for delayed-release dosage forms in disintegration and dissolution tests, they usually find practical application. This literature review presents their composition and properties. Since ECDDT is a new technology, this article is based on a limited number of references.
ER  -

FRANC, Aleš, David VETCHÝ a Nicole FÜLÖPOVÁ. Commercially Available Enteric Empty Hard Capsules, Production Technology and Application. \textit{Pharmaceuticals}. BASEL: MDPI, 2022, roč.~15, č.~11, s.~1-19. ISSN~1424-8247. Dostupné z: https://dx.doi.org/10.3390/ph15111398.

Podrobný výpis o publikaci