| TOPORCEROVA, Silvia, Ivana SPAKOVA, Katarina SOLTYS, Zuzana KLEPCOVA, Marek KLOC, Júlia BOHOŠOVÁ, Karolína TRACHTOVÁ, Lucia PETEROVA, Helena MICKOVA, Peter URDZIK, Maria MAREKOVA, Ondřej SLABÝ a Miroslava RABAJDOVA. Small Non-Coding RNAs as New Biomarkers to Evaluate the Quality of the Embryo in the IVF Process. Biomolecules. Basel, Switzerland: MDPI AG, 2022, roč. 12, č. 11, s. 1687-1702. ISSN 2218-273X. Dostupné z: https://dx.doi.org/10.3390/biom12111687. |
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@article{2252340,
author = {Toporcerova, Silvia and Spakova, Ivana and Soltys, Katarina and Klepcova, Zuzana and Kloc, Marek and Bohošová, Júlia and Trachtová, Karolína and Peterova, Lucia and Mickova, Helena and Urdzik, Peter and Marekova, Maria and Slabý, Ondřej and Rabajdova, Miroslava},
article_location = {Basel, Switzerland},
article_number = {11},
doi = {http://dx.doi.org/10.3390/biom12111687},
keywords = {miRNA; piRNA; biomarker; IVF; embryo selection; embryonic secretome},
language = {eng},
issn = {2218-273X},
journal = {Biomolecules},
title = {Small Non-Coding RNAs as New Biomarkers to Evaluate the Quality of the Embryo in the IVF Process},
url = {https://www.mdpi.com/2218-273X/12/11/1687},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 2252340
AU - Toporcerova, Silvia - Spakova, Ivana - Soltys, Katarina - Klepcova, Zuzana - Kloc, Marek - Bohošová, Júlia - Trachtová, Karolína - Peterova, Lucia - Mickova, Helena - Urdzik, Peter - Marekova, Maria - Slabý, Ondřej - Rabajdova, Miroslava
PY - 2022
TI - Small Non-Coding RNAs as New Biomarkers to Evaluate the Quality of the Embryo in the IVF Process
JF - Biomolecules
VL - 12
IS - 11
SP - 1687
EP - 1687
PB - MDPI AG
SN - 2218273X
KW - miRNA
KW - piRNA
KW - biomarker
KW - IVF
KW - embryo selection
KW - embryonic secretome
UR - https://www.mdpi.com/2218-273X/12/11/1687
N2 - The increased interest in assisted reproduction through in vitro fertilization (IVF) leads to an urgent need to identify biomarkers that reliably highly predict the success of pregnancy. Despite advances in diagnostics, treatment, and IVF approaches, the 30% success rate of IVF seems insurmountable. Idiopathic infertility does not have any explanation for IVF failure especially when a patient is treated with a healthy competitive embryo capable of implantation and development. Since appropriate intercellular communication is essential after embryo implantation, the emergence of the investigation of embryonic secretome including short non-coding RNA (sncRNA) molecules is crucial. That's why biomarker identification, sncRNAs secreted during the IVF process into the blastocyst's cultivation medium, by the implementation of artificial intelligence opens the door to a better understanding of the bidirectional communication between embryonic cells and the endometrium and so the success of the IVF. This study presents a set of promising new sncRNAs which are revealed to predictively distinguish a high-quality embryo, suitable for an embryo transfer in the IVF process, from a low-quality embryo with 86% accuracy. The identified exact combination of miRNAs/piRNAs as a non-invasively obtained biomarker for quality embryo determination, increasing the likelihood of implantation and the success of pregnancy after an embryo transfer.
ER -
TOPORCEROVA, Silvia, Ivana SPAKOVA, Katarina SOLTYS, Zuzana KLEPCOVA, Marek KLOC, Júlia BOHOŠOVÁ, Karolína TRACHTOVÁ, Lucia PETEROVA, Helena MICKOVA, Peter URDZIK, Maria MAREKOVA, Ondřej SLABÝ a Miroslava RABAJDOVA. Small Non-Coding RNAs as New Biomarkers to Evaluate the Quality of the Embryo in the IVF Process. \textit{Biomolecules}. Basel, Switzerland: MDPI AG, 2022, roč.~12, č.~11, s.~1687-1702. ISSN~2218-273X. Dostupné z: https://dx.doi.org/10.3390/biom12111687.
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