2023
Brain Tissue Oxygen Levels as a Perspective Therapeutic Target in Traumatic Brain Injury. Retrospective Cohort Study
GÁL, Roman, Ondřej HRDÝ, Kamil VRBICA, Jan HUDEC, Andrej MRLIAN et. al.Základní údaje
Originální název
Brain Tissue Oxygen Levels as a Perspective Therapeutic Target in Traumatic Brain Injury. Retrospective Cohort Study
Autoři
GÁL, Roman (203 Česká republika, domácí), Ondřej HRDÝ (203 Česká republika, garant, domácí), Kamil VRBICA (203 Česká republika, domácí), Jan HUDEC (203 Česká republika, domácí), Andrej MRLIAN (703 Slovensko, domácí) a Martin SMRČKA (203 Česká republika, domácí)
Vydání
The Journal of Critical Care Medicine, MAZOVIA, SCIENDO, 2023, 2393-1809
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30221 Critical care medicine and Emergency medicine
Stát vydavatele
Polsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 1.100 v roce 2022
Kód RIV
RIV/00216224:14110/23:00130280
Organizační jednotka
Lékařská fakulta
UT WoS
000930691100003
Klíčová slova anglicky
critical care; traumatic brain injury; Glasgow Outcome Scale; brain tissue oxygen
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 5. 4. 2024 07:44, Mgr. Tereza Miškechová
Anotace
V originále
Introduction: Management of traumatic brain injury (TBI) requires a multidisciplinary approach and represents a significant challenge for both neurosurgeons and intensivists. The role of brain tissue oxygenation (PbtO2) monitoring and its impact on posttraumatic outcomes remains a controversial topic. Aim of the study: Our study aimed to evaluate the impact of PbtO2 monitoring on mortality, 30 days and 6 months neurological outcomes in patients with severe TBI compared with those resulting from standard intracranial pressure (ICP) monitoring. Material and methods: In this retrospective cohort study, we analysed the outcomes of 77 patients with severe TBI who met the inclusion criteria. These patients were divided into two groups, including 37 patients who were managed with ICP and PbtO2 monitoring protocols and 40 patients who were managed using ICP protocols alone. Results: There were no significant differences in demographic data between the two groups. We found no statistically significant differences in mortality or Glasgow Outcome Scale (GOS) scores one month after TBI. However, our results revealed that GOS scores at 6 months had improved significantly among patients managed with PbtO2; this finding was particularly notable for Glasgow Outcome Scale (GOS) scores of 4–5. Close monitoring and management of reductions in PbtO2, particularly by increasing the fraction of inspired oxygen, was associated with higher partial pressures of oxygen in this group. Conclusions: Monitoring of PbtO2 may facilitate the appropriate evaluation and treatment of low PbtO2 and represents a promising tool for the management of patients with severe TBI. Additional studies will be needed to confirm these findings.
Návaznosti
MUNI/A/1058/2019, interní kód MU |
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MUNI/A/1091/2020, interní kód MU |
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