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@article{2253648,
author = {Fajkus, Petr and Adámik, Matej and Nelson, Andrew D L and Kilar, Agata Magdalena and Franek, Michal and Bubeník, Michal and Frydrychova, Radmila Capkova and Votavova, Alena and Sýkorová, Eva and Fajkus, Jiří and Peška, Vratislav},
article_location = {Oxford},
article_number = {1},
doi = {http://dx.doi.org/10.1093/nar/gkac1202},
keywords = {TEMPLATE-BOUNDARY DEFINITION;PSEUDOKNOT;SEQUENCE;IDENTIFICATION},
language = {eng},
issn = {0305-1048},
journal = {Nucleic acids research},
title = {Telomerase RNA in Hymenoptera (Insecta) switched to plant/ciliate-like biogenesis},
url = {https://academic.oup.com/nar/article/51/1/420/6956357},
volume = {51},
year = {2023}
}
TY - JOUR
ID - 2253648
AU - Fajkus, Petr - Adámik, Matej - Nelson, Andrew D L - Kilar, Agata Magdalena - Franek, Michal - Bubeník, Michal - Frydrychova, Radmila Capkova - Votavova, Alena - Sýkorová, Eva - Fajkus, Jiří - Peška, Vratislav
PY - 2023
TI - Telomerase RNA in Hymenoptera (Insecta) switched to plant/ciliate-like biogenesis
JF - Nucleic acids research
VL - 51
IS - 1
SP - 420-433
EP - 420-433
PB - Oxford University Press
SN - 03051048
KW - TEMPLATE-BOUNDARY DEFINITION;PSEUDOKNOT;SEQUENCE;IDENTIFICATION
UR - https://academic.oup.com/nar/article/51/1/420/6956357
N2 - In contrast to the catalytic subunit of telomerase, its RNA subunit (TR) is highly divergent in size, sequence and biogenesis pathways across eukaryotes. Current views on TR evolution assume a common origin of TRs transcribed with RNA polymerase II in Opisthokonta (the supergroup including Animalia and Fungi) and Trypanosomida on one hand, and TRs transcribed with RNA polymerase III under the control of type 3 promoter, found in TSAR and Archaeplastida supergroups (including e.g. ciliates and Viridiplantae taxa, respectively). Here, we focus on unknown TRs in one of the largest Animalia order - Hymenoptera (Arthropoda) with more than 300 available representative genomes. Using a combination of bioinformatic and experimental approaches, we identify their TRs. In contrast to the presumed type of TRs (H/ACA box snoRNAs transcribed with RNA Polymerase II) corresponding to their phylogenetic position, we find here short TRs of the snRNA type, likely transcribed with RNA polymerase III under the control of the type 3 promoter. The newly described insect TRs thus question the hitherto assumed monophyletic origin of TRs across Animalia and point to an evolutionary switch in TR type and biogenesis that was associated with the divergence of Arthropods.
ER -
FAJKUS, Petr, Matej ADÁMIK, Andrew D L NELSON, Agata Magdalena KILAR, Michal FRANEK, Michal BUBENÍK, Radmila Capkova FRYDRYCHOVA, Alena VOTAVOVA, Eva SÝKOROVÁ, Jiří FAJKUS and Vratislav PEŠKA. Telomerase RNA in Hymenoptera (Insecta) switched to plant/ciliate-like biogenesis. \textit{Nucleic acids research}. Oxford: Oxford University Press, 2023, vol.~51, No~1, p.~420-433. ISSN~0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkac1202.
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