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@article{2254099, author = {Eyer, Luděk and SeleyandRadtke, Katherine and Růžek, Daniel}, article_number = {February}, doi = {http://dx.doi.org/10.1016/j.antiviral.2022.105504}, keywords = {Tick-borne encephalitis; Tick-borne encephalitis virus; Antivirals; Monoclonal antibodies; Immunotherapy}, language = {eng}, issn = {0166-3542}, journal = {Antiviral Research}, title = {New directions in the experimental therapy of tick-borne encephalitis.}, url = {https://doi.org/10.1016/j.antiviral.2022.105504}, volume = {210}, year = {2023} }
TY - JOUR ID - 2254099 AU - Eyer, Luděk - Seley-Radtke, Katherine - Růžek, Daniel PY - 2023 TI - New directions in the experimental therapy of tick-borne encephalitis. JF - Antiviral Research VL - 210 IS - February SP - 1-6 EP - 1-6 PB - Elsevier B.V. SN - 01663542 KW - Tick-borne encephalitis KW - Tick-borne encephalitis virus KW - Antivirals KW - Monoclonal antibodies KW - Immunotherapy UR - https://doi.org/10.1016/j.antiviral.2022.105504 N2 - Tick-borne encephalitis (TBE) is a potentially fatal disease common in much of Europe and Asia. There is no specific therapy for the treatment of TBE patients. However, several efforts are being made to develop small molecules that specifically interfere with the life cycle of TBE virus. In particular, recently various nucleoside analogues that can inhibit the viral replicase, such as the RNA-dependent RNA polymerase or viral methyltransferases, have been explored. In addition, human or chimeric (i.e., structural chimeras that combine mouse variable domains with human constant domains) monoclonal antibodies with promising potential for post-exposure prophylaxis or early therapy have been developed. This review summarizes the latest directions and experimental approaches that may be used to combat TBE in humans. ER -
EYER, Luděk, Katherine SELEY-RADTKE a Daniel RŮŽEK. New directions in the experimental therapy of tick-borne encephalitis. \textit{Antiviral Research}. Elsevier B.V., 2023, roč.~210, February, s.~1-6. ISSN~0166-3542. Dostupné z: https://dx.doi.org/10.1016/j.antiviral.2022.105504.
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