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@article{2255498,
author = {Juráček, Jaroslav and Mądrzyk, Marie and Staník, Michal and Slabý, Ondřej},
article_number = {13},
doi = {http://dx.doi.org/10.3390/cancers14133157},
keywords = {prostate cancer; microRNA; urine; extracellular vesicles; diagnosis},
language = {eng},
issn = {2072-6694},
journal = {CANCERS},
title = {Urinary microRNAs and Their Significance in Prostate Cancer Diagnosis: A 5-Year Update},
url = {https://www.mdpi.com/2072-6694/14/13/3157},
volume = {14},
year = {2022}
}
TY - JOUR
ID - 2255498
AU - Juráček, Jaroslav - Mądrzyk, Marie - Staník, Michal - Slabý, Ondřej
PY - 2022
TI - Urinary microRNAs and Their Significance in Prostate Cancer Diagnosis: A 5-Year Update
JF - CANCERS
VL - 14
IS - 13
SP - 3157
EP - 3157
PB - MDPI
SN - 20726694
KW - prostate cancer
KW - microRNA
KW - urine
KW - extracellular vesicles
KW - diagnosis
UR - https://www.mdpi.com/2072-6694/14/13/3157
N2 - Simple Summary Current diagnostics of prostate cancer often show unsatisfactory results, leading to delayed detection or overtreatment. Urinary microRNAs are a class of promising non-invasive biomarkers. Although many studies have been conducted on this topic in the last five years, there is little agreement on the data obtained. This review aims to discuss new knowledge but also focuses on technical aspects affecting urinary miRNA analysis. Current routine screening methods for the diagnosis of prostate cancer (PCa) have significantly increased early detection of the disease but often show unsatisfactory analytical parameters. A class of promising markers represents urinary microRNAs (miRNAs). In the last five years, there has been an extensive increase in the number of studies on this topic. Thus, this review aims to update knowledge and point out technical aspects affecting urinary miRNA analysis. The review of relevant literature was carried out by searching the PubMed database for the keywords: microRNA, miRNA, urine, urinary, prostate cancer, and diagnosis. Papers discussed in this review were retrieved using PubMed, and the search strategy was as follows: (urine OR urinary) WITH (microRNA OR miRNA) AND prostate cancer. The search was limited to the last 5 years, January 2017 to December 2021. Based on the defined search strategy, 31 original publications corresponding to the research topic were identified, read and reviewed to present the latest findings and to assess possible translation of urinary miRNAs into clinical practice. Reviews or older publications were read and cited if they valuably extended the context and contributed to a better understanding. Urinary miRNAs are potentially valuable markers for the diagnosis of prostate cancer. Despite promising results, there is still a need for independent validation of exploratory data, which follows a strict widely accepted methodology taking into account the shortcomings and factors influencing the analysis.
ER -
JURÁČEK, Jaroslav, Marie MĄDRZYK, Michal STANÍK a Ondřej SLABÝ. Urinary microRNAs and Their Significance in Prostate Cancer Diagnosis: A 5-Year Update. \textit{CANCERS}. MDPI, 2022, roč.~14, č.~13, s.~3157-3173. ISSN~2072-6694. Dostupné z: https://dx.doi.org/10.3390/cancers14133157.
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