| KAMEDA-SMITH, Michelle M. M., Helen ZHU, En-Ching LUO, Yujin SUK, Agata XELLA, Brian YEE, Chirayu CHOKSHI, Sansi XING, Frederick TAN, Raymond G. G. FOX, Ashley A. A. ADILE, David BAKHSHINYAN, Kevin BROWN, William D. D. GWYNNE, Minomi SUBAPANDITHA, Petar MILETIC, Daniel PICARD, Ian BURNS, Jason MOFFAT, Kamil PARUCH, Adam FLEMING, Kristin HOPE, John P P PROVIAS, Marc REMKE, Yu LU, Tannishtha REYA, Chitra VENUGOPAL, Juri REIMAND, Robert J J WECHSLER-REYA, Gene W W YEO a Sheila K K SINGH. Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma. Nature Communications. Nature Portfolio, 2022, roč. 13, č. 1, s. 1-19. ISSN 2041-1723. Dostupné z: https://dx.doi.org/10.1038/s41467-022-35118-3. |
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@article{2255537,
author = {KamedaandSmith, Michelle M. M. and Zhu, Helen and Luo, EnandChing and Suk, Yujin and Xella, Agata and Yee, Brian and Chokshi, Chirayu and Xing, Sansi and Tan, Frederick and Fox, Raymond G. G. and Adile, Ashley A. A. and Bakhshinyan, David and Brown, Kevin and Gwynne, William D. D. and Subapanditha, Minomi and Miletic, Petar and Picard, Daniel and Burns, Ian and Moffat, Jason and Paruch, Kamil and Fleming, Adam and Hope, Kristin and Provias, John P P and Remke, Marc and Lu, Yu and Reya, Tannishtha and Venugopal, Chitra and Reimand, Juri and WechslerandReya, Robert J J and Yeo, Gene W W and Singh, Sheila K K},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41467-022-35118-3},
keywords = {Cancer stem cells; Neural stem cells; Paediatric cancer},
language = {eng},
issn = {2041-1723},
journal = {Nature Communications},
title = {Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma},
url = {https://doi.org/10.1038/s41467-022-35118-3},
volume = {13},
year = {2022}
}
TY - JOUR
ID - 2255537
AU - Kameda-Smith, Michelle M. M. - Zhu, Helen - Luo, En-Ching - Suk, Yujin - Xella, Agata - Yee, Brian - Chokshi, Chirayu - Xing, Sansi - Tan, Frederick - Fox, Raymond G. G. - Adile, Ashley A. A. - Bakhshinyan, David - Brown, Kevin - Gwynne, William D. D. - Subapanditha, Minomi - Miletic, Petar - Picard, Daniel - Burns, Ian - Moffat, Jason - Paruch, Kamil - Fleming, Adam - Hope, Kristin - Provias, John P P - Remke, Marc - Lu, Yu - Reya, Tannishtha - Venugopal, Chitra - Reimand, Juri - Wechsler-Reya, Robert J J - Yeo, Gene W W - Singh, Sheila K K
PY - 2022
TI - Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma
JF - Nature Communications
VL - 13
IS - 1
SP - 1-19
EP - 1-19
PB - Nature Portfolio
SN - 20411723
KW - Cancer stem cells
KW - Neural stem cells
KW - Paediatric cancer
UR - https://doi.org/10.1038/s41467-022-35118-3
N2 - Pediatric medulloblastoma (MB) is the most common solid malignant brain neoplasm, with Group 3 (G3) MB representing the most aggressive subgroup. MYC amplification is an independent poor prognostic factor in G3 MB, however, therapeutic targeting of the MYC pathway remains limited and alternative therapies for G3 MB are urgently needed. Here we show that the RNA-binding protein, Musashi-1 (MSI1) is an essential mediator of G3 MB in both MYC-overexpressing mouse models and patient-derived xenografts. MSI1 inhibition abrogates tumor initiation and significantly prolongs survival in both models. We identify binding targets of MSI1 in normal neural and G3 MB stem cells and then cross referenced these data with unbiased large-scale screens at the transcriptomic, translatomic and proteomic levels to systematically dissect its functional role. Comparative integrative multi-omic analyses of these large datasets reveal cancer-selective MSI1-bound targets sharing multiple MYC associated pathways, providing a valuable resource for context-specific therapeutic targeting of G3 MB.
ER -
KAMEDA-SMITH, Michelle M. M., Helen ZHU, En-Ching LUO, Yujin SUK, Agata XELLA, Brian YEE, Chirayu CHOKSHI, Sansi XING, Frederick TAN, Raymond G. G. FOX, Ashley A. A. ADILE, David BAKHSHINYAN, Kevin BROWN, William D. D. GWYNNE, Minomi SUBAPANDITHA, Petar MILETIC, Daniel PICARD, Ian BURNS, Jason MOFFAT, Kamil PARUCH, Adam FLEMING, Kristin HOPE, John P P PROVIAS, Marc REMKE, Yu LU, Tannishtha REYA, Chitra VENUGOPAL, Juri REIMAND, Robert J J WECHSLER-REYA, Gene W W YEO a Sheila K K SINGH. Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma. \textit{Nature Communications}. Nature Portfolio, 2022, roč.~13, č.~1, s.~1-19. ISSN~2041-1723. Dostupné z: https://dx.doi.org/10.1038/s41467-022-35118-3.
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