The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen
Metabolism in the Pathogenic Filamentous Fungus Aspergillus
fumigatus

J 2023

The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus

ŠÁMALOVÁ, Markéta; Patricia FLAMANT; Rémi BEAU; Mike BROMLEY; Maryse MOYA-NILGES et al.

Základní údaje

Originální název

The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus

Autoři

ŠÁMALOVÁ, Markéta; Patricia FLAMANT; Rémi BEAU; Mike BROMLEY; Maryse MOYA-NILGES; Thierry FONTAINE; Jean-Paul LATGÉ a Isabelle MOUYNA

Vydání

Journal of Fungi, MDPI, 2023, 2309-608X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10611 Plant sciences, botany

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.200

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/23:00130334

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Aspergillus fumigatus; conidia; cell wall; GPI-anchored protein; morphogenesis; nitrogen metabolism

Štítky

14314010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 3. 2023 09:55, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

GPI-anchored proteins display very diverse biological (biochemical and immunological) functions. An in silico analysis has revealed that the genome of Aspergillus fumigatus contains 86 genes coding for putative GPI-anchored proteins (GPI-APs). Past research has demonstrated the involvement of GPI-APs in cell wall remodeling, virulence, and adhesion. We analyzed a new GPI-anchored protein called SwgA. We showed that this protein is mainly present in the Clavati of Aspergillus and is absent from yeasts and other molds. The protein, localized in the membrane of A. fumigatus, is involved in germination, growth, and morphogenesis, and is associated with nitrogen metabolism and thermosensitivity. swgA is controlled by the nitrogen regulator AreA. This current study indicates that GPI-APs have more general functions in fungal metabolism than cell wall biosynthesis.

Přiložené soubory

Samalova_JoF_2023.pdf

Citovat

ŠÁMALOVÁ, Markéta; Patricia FLAMANT; Rémi BEAU; Mike BROMLEY; Maryse MOYA-NILGES; Thierry FONTAINE; Jean-Paul LATGÉ a Isabelle MOUYNA. The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus. Journal of Fungi. MDPI, 2023, roč. 9, č. 2, s. 1-15. ISSN 2309-608X. Dostupné z: https://doi.org/10.3390/jof9020256.

@article{2255797,
   author = {Šámalová, Markéta and Flamant, Patricia and Beau, Rémi and Bromley, Mike and MoyaandNilges, Maryse and Fontaine, Thierry and Latgé, JeanandPaul and Mouyna, Isabelle},
   article_number = {2},
   doi = {https://doi.org/10.3390/jof9020256},
   keywords = {Aspergillus fumigatus; conidia; cell wall; GPI-anchored protein; morphogenesis; nitrogen metabolism},
   language = {eng},
   issn = {2309-608X},
   journal = {Journal of Fungi},
   title = {The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus},
   url = {https://www.mdpi.com/2309-608X/9/2/256},
   volume = {9},
   year = {2023}
}

TY  - JOUR
ID  - 2255797
AU  - Šámalová, Markéta - Flamant, Patricia - Beau, Rémi - Bromley, Mike - Moya-Nilges, Maryse - Fontaine, Thierry - Latgé, Jean-Paul - Mouyna, Isabelle
PY  - 2023
TI  - The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus
JF  - Journal of Fungi
VL  - 9
IS  - 2
SP  - 1-15
EP  - 1-15
PB  - MDPI
SN  - 2309608X
KW  - Aspergillus fumigatus
KW  - conidia
KW  - cell wall
KW  - GPI-anchored protein
KW  - morphogenesis
KW  - nitrogen metabolism
UR  - https://www.mdpi.com/2309-608X/9/2/256
N2  - GPI-anchored proteins display very diverse biological (biochemical and immunological) functions. An in silico analysis has revealed that the genome of Aspergillus fumigatus contains 86 genes coding for putative GPI-anchored proteins (GPI-APs). Past research has demonstrated the involvement of GPI-APs in cell wall remodeling, virulence, and adhesion. We analyzed a new GPI-anchored protein called SwgA. We showed that this protein is mainly present in the Clavati of Aspergillus and is absent from yeasts and other molds. The protein, localized in the membrane of A. fumigatus, is involved in germination, growth, and morphogenesis, and is associated with nitrogen metabolism and thermosensitivity. swgA is controlled by the nitrogen regulator AreA. This current study indicates that GPI-APs have more general functions in fungal metabolism than cell wall biosynthesis.
ER  -

ŠÁMALOVÁ, Markéta; Patricia FLAMANT; Rémi BEAU; Mike BROMLEY; Maryse MOYA-NILGES; Thierry FONTAINE; Jean-Paul LATGÉ a Isabelle MOUYNA. The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus. \textit{Journal of Fungi}. MDPI, 2023, roč.~9, č.~2, s.~1-15. ISSN~2309-608X. Dostupné z: https://doi.org/10.3390/jof9020256.

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