A haemochromatosis-causing HFE mutation is associated with
SARS-CoV-2 susceptibility in the Czech population

J 2023

A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population

HUBACEK, J. A., T. PHILIPP, V. ADAMKOVA, Ondřej MÁJEK, Ladislav DUŠEK et. al.

Základní údaje

Originální název

A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population

Autoři

HUBACEK, J. A. (203 Česká republika, garant), T. PHILIPP (203 Česká republika), V. ADAMKOVA (203 Česká republika), Ondřej MÁJEK (203 Česká republika, domácí) a Ladislav DUŠEK (203 Česká republika, domácí)

Vydání

Clinica Chimica Acta, AMSTERDAM, ELSEVIER SCIENCE BV, 2023, 0009-8981

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30230 Other clinical medicine subjects

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.000 v roce 2022

Kód RIV

RIV/00216224:14110/23:00130381

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.cca.2022.12.025

UT WoS

000923428500001

Klíčová slova anglicky

COVID-19; HFE; Iron; Polymorphism; Susceptibility

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 2. 2023 08:21, Mgr. Tereza Miškechová

Anotace

V originále

Background: Coronavirus disease (COVID-19), which is caused by the SARS-CoV-2 virus, has become a global pandemic. While susceptibility to COVID-19 is subject to several external factors, including hypertension, BMI, and the presence of diabetes, it is also genetically determined to a significant extent. Infectious agents require iron (Fe) for proper functioning. Carriers of mutations resulting in increased iron concentrations are understood to be at increased risk of COVID-19.Methods: We examined HFE genotypes associated with hereditary haemochromatosis (rs1800562 and rs1799945 SNPs) in 617 COVID-19 patients (166 asymptomatic, 246 symptomatic and 205 hospitalised survivors) and 2 559 population-based controls.Results: We found a higher frequency of the minor allele (Tyr282) of the rs1800562 polymorphism (P < 0.002) in patients compared to controls (8.5 % vs 5.5 %). Non-carriers of the minor allele were protected against SARS-Cov-2 infection (OR, 95 %CI; 0.59, 0.42-0.82). The frequency of minor allele carriers was almost identical across asymptomatic, symptomatic, and hospitalised survivors. The rs1799945 variant did not affect disease severity and its occurrence was almost identical in patients and controls (P between 0.58 and 0.84).Conclusions: In conclusion, our results indicate that presence of the rs1800562 minor allele, which is associated with hereditary haemochromatosis (thus increased levels of plasma Fe), increases susceptibility to SARS-CoV-2.

Citovat

HUBACEK, J. A., T. PHILIPP, V. ADAMKOVA, Ondřej MÁJEK a Ladislav DUŠEK. A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population. Clinica Chimica Acta. AMSTERDAM: ELSEVIER SCIENCE BV, 2023, roč. 538, January 2023, s. 211-215. ISSN 0009-8981. Dostupné z: https://dx.doi.org/10.1016/j.cca.2022.12.025.

@article{2262097,
   author = {Hubacek, J. A. and Philipp, T. and Adamkova, V. and Májek, Ondřej and Dušek, Ladislav},
   article_location = {AMSTERDAM},
   article_number = {January 2023},
   doi = {http://dx.doi.org/10.1016/j.cca.2022.12.025},
   keywords = {COVID-19; HFE; Iron; Polymorphism; Susceptibility},
   language = {eng},
   issn = {0009-8981},
   journal = {Clinica Chimica Acta},
   title = {A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population},
   url = {https://www.sciencedirect.com/science/article/pii/S0009898122014279?via%3Dihub},
   volume = {538},
   year = {2023}
}

TY  - JOUR
ID  - 2262097
AU  - Hubacek, J. A. - Philipp, T. - Adamkova, V. - Májek, Ondřej - Dušek, Ladislav
PY  - 2023
TI  - A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population
JF  - Clinica Chimica Acta
VL  - 538
IS  - January 2023
SP  - 211-215
EP  - 211-215
PB  - ELSEVIER SCIENCE BV
SN  - 00098981
KW  - COVID-19
KW  - HFE
KW  - Iron
KW  - Polymorphism
KW  - Susceptibility
UR  - https://www.sciencedirect.com/science/article/pii/S0009898122014279?via%3Dihub
N2  - Background: Coronavirus disease (COVID-19), which is caused by the SARS-CoV-2 virus, has become a global pandemic. While susceptibility to COVID-19 is subject to several external factors, including hypertension, BMI, and the presence of diabetes, it is also genetically determined to a significant extent. Infectious agents require iron (Fe) for proper functioning. Carriers of mutations resulting in increased iron concentrations are understood to be at increased risk of COVID-19.Methods: We examined HFE genotypes associated with hereditary haemochromatosis (rs1800562 and rs1799945 SNPs) in 617 COVID-19 patients (166 asymptomatic, 246 symptomatic and 205 hospitalised survivors) and 2 559 population-based controls.Results: We found a higher frequency of the minor allele (Tyr282) of the rs1800562 polymorphism (P < 0.002) in patients compared to controls (8.5 % vs 5.5 %). Non-carriers of the minor allele were protected against SARS-Cov-2 infection (OR, 95 %CI; 0.59, 0.42-0.82). The frequency of minor allele carriers was almost identical across asymptomatic, symptomatic, and hospitalised survivors. The rs1799945 variant did not affect disease severity and its occurrence was almost identical in patients and controls (P between 0.58 and 0.84).Conclusions: In conclusion, our results indicate that presence of the rs1800562 minor allele, which is associated with hereditary haemochromatosis (thus increased levels of plasma Fe), increases susceptibility to SARS-CoV-2.
ER  -

HUBACEK, J. A., T. PHILIPP, V. ADAMKOVA, Ondřej MÁJEK a Ladislav DUŠEK. A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population. \textit{Clinica Chimica Acta}. AMSTERDAM: ELSEVIER SCIENCE BV, 2023, roč.~538, January 2023, s.~211-215. ISSN~0009-8981. Dostupné z: https://dx.doi.org/10.1016/j.cca.2022.12.025.

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