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@article{2262407,
author = {Muenster, Lukas and Capakova, Zdenka and Humpolicek, Petr and Kuritka, Ivo and Christensen, Bjorn E and Vicha, Jan},
article_location = {Oxford},
article_number = {SEP},
doi = {http://dx.doi.org/10.1016/j.carbpol.2022.119661},
keywords = {Sodium hyaluronate; Selective oxidation; Periodate oxidation; Chlorite oxidation; Dicarboxylated hyaluronate; Cisplatin},
language = {eng},
issn = {0144-8617},
journal = {Carbohydrate Polymers},
title = {Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative},
url = {https://www.sciencedirect.com/science/article/pii/S0144861722005665?via%3Dihub},
volume = {292},
year = {2022}
}
TY - JOUR
ID - 2262407
AU - Muenster, Lukas - Capakova, Zdenka - Humpolicek, Petr - Kuritka, Ivo - Christensen, Bjorn E - Vicha, Jan
PY - 2022
TI - Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative
JF - Carbohydrate Polymers
VL - 292
IS - SEP
SP - 119661
EP - 119661
PB - ELSEVIER SCI LTD
SN - 01448617
KW - Sodium hyaluronate
KW - Selective oxidation
KW - Periodate oxidation
KW - Chlorite oxidation
KW - Dicarboxylated hyaluronate
KW - Cisplatin
UR - https://www.sciencedirect.com/science/article/pii/S0144861722005665?via%3Dihub
N2 - Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of -COOH groups at C2 and C3 carbons of oxidized ?-glucuronic acid units, is investigated. The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties. Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines. DCH derivatives were found to be superior in every aspect, having nearly twice the carrier capacity, significantly slower release rates, and higher efficacy. DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications.
ER -
MUENSTER, Lukas, Zdenka CAPAKOVA, Petr HUMPOLICEK, Ivo KURITKA, Bjorn E CHRISTENSEN and Jan VICHA. Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative. \textit{Carbohydrate Polymers}. Oxford: ELSEVIER SCI LTD, 2022, vol.~292, SEP, p.~119661-119673. ISSN~0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2022.119661.
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