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@article{2262441, author = {Kanderova, Veronika and Svobodova, Tamara and Borna, Simon and Fejtkova, Martina and Martinu, Vendula and Paderova, Jana and Svaton, Michael and Kralova, Jarmila and Fronkova, Eva and Klocperk, Adam and Pruhova, Stepanka and LeeandKirsch, Min Ae and Hornofova, Ludmila and Koblizek, Miroslav and Novak, Petr and Zimmermannova, Olga and Parackova, Zuzana and Sediva, Anna and Kalina, Tomas and Janda, Ales and Kayserova, Jana and Dvorakova, Marcela and Macek, Milan and Pohunek, Petr and Sedlacek, Petr and Poh, Ashleigh and Ernst, Matthias and Brdicka, Tomas and Hrusak, Ondrej and Lebl, Jan}, article_location = {New York}, article_number = {4}, doi = {http://dx.doi.org/10.1016/j.jaci.2021.07.046}, keywords = {SRC-family kinase; hematopoietic cell kinase; inborn error of immunity; pulmonary hemorrhage; cutaneous vasculitis; autoinflammation; inflammatory cytokines; reactive oxygen species; ruxolitinib}, language = {eng}, issn = {0091-6749}, journal = {Journal of allergy and clinical immunology}, title = {Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK}, url = {https://www.sciencedirect.com/science/article/pii/S0091674921013956?via%3Dihub}, volume = {149}, year = {2022} }
TY - JOUR ID - 2262441 AU - Kanderova, Veronika - Svobodova, Tamara - Borna, Simon - Fejtkova, Martina - Martinu, Vendula - Paderova, Jana - Svaton, Michael - Kralova, Jarmila - Fronkova, Eva - Klocperk, Adam - Pruhova, Stepanka - Lee-Kirsch, Min Ae - Hornofova, Ludmila - Koblizek, Miroslav - Novak, Petr - Zimmermannova, Olga - Parackova, Zuzana - Sediva, Anna - Kalina, Tomas - Janda, Ales - Kayserova, Jana - Dvorakova, Marcela - Macek, Milan - Pohunek, Petr - Sedlacek, Petr - Poh, Ashleigh - Ernst, Matthias - Brdicka, Tomas - Hrusak, Ondrej - Lebl, Jan PY - 2022 TI - Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK JF - Journal of allergy and clinical immunology VL - 149 IS - 4 SP - 1464-1472 EP - 1464-1472 PB - Mosby-Elsevier SN - 00916749 KW - SRC-family kinase KW - hematopoietic cell kinase KW - inborn error of immunity KW - pulmonary hemorrhage KW - cutaneous vasculitis KW - autoinflammation KW - inflammatory cytokines KW - reactive oxygen species KW - ruxolitinib UR - https://www.sciencedirect.com/science/article/pii/S0091674921013956?via%3Dihub N2 - Background: Inborn errors of immunity are genetic disorders characterized by various degrees of immune dysregulation that can manifest as immune deficiency, autoimmunity, or autoinflammation. The routine use of next-generation sequencing in the clinic has facilitated the identification of an ever-increasing number of inborn errors of immunity, revealing the roles of immunologically important genes in human pathologies. However, despite this progress, treatment is still extremely challenging. Objective: We sought to report a new monogenic autoinflammatory disorder caused by a de novo activating mutation, p.Tyr515*, in hematopoietic cell kinase (HCK). The disease is characterized by cutaneous vasculitis and chronic pulmonary inflammation that progresses to fibrosis. Methods: Whole-exome sequencing, Sanger sequencing, mass spectrometry, and western blotting were performed to identify and characterize the pathogenic HCK mutation. Dysregulation of mutant HCK was confirmed ex vivo in primary cells and in vitro in transduced cell lines. Results: Mutant HCK lacking the C-terminal inhibitory tyrosine Tyr522 exhibited increased kinase activity and enhanced myeloid cell priming, migration and effector functions, such as production of the inflammatory cytokines IL-1 beta, IL-6, IL-8, and TNF-alpha, and production of reactive oxygen species. These aberrant functions were reflected by inflammatory leukocyte infiltration of the lungs and skin. Moreover, an overview of the clinical course of the disease, including therapies, provides evidence for the therapeutic efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in inflammatory lung disease. Conclusions: We propose HCK-driven pulmonary and cutaneous vasculitis as a novel autoinflammatory disorder of inborn errors of immunity. ER -
KANDEROVA, Veronika, Tamara SVOBODOVA, Simon BORNA, Martina FEJTKOVA, Vendula MARTINU, Jana PADEROVA, Michael SVATON, Jarmila KRALOVA, Eva FRONKOVA, Adam KLOCPERK, Stepanka PRUHOVA, Min Ae LEE-KIRSCH, Ludmila HORNOFOVA, Miroslav KOBLIZEK, Petr NOVAK, Olga ZIMMERMANNOVA, Zuzana PARACKOVA, Anna SEDIVA, Tomas KALINA, Ales JANDA, Jana KAYSEROVA, Marcela DVORAKOVA, Milan MACEK, Petr POHUNEK, Petr SEDLACEK, Ashleigh POH, Matthias ERNST, Tomas BRDICKA, Ondrej HRUSAK a Jan LEBL. Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK. \textit{Journal of allergy and clinical immunology}. New York: Mosby-Elsevier, 2022, roč.~149, č.~4, s.~1464-1472, 12 s. ISSN~0091-6749. Dostupné z: https://dx.doi.org/10.1016/j.jaci.2021.07.046.
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