| KRACIKOVA, Lucie, Natalia ZIOLKOWSKA, Ladislav ANDROVIC, Iveta KLIMANKOVA, David CERVENY, Martin VIT, Petr POMPACH, Rafal KONEFAL, Olga JANOUSKOVA, Martin HRUBY, Daniel JIRAK a Richard LAGA. Phosphorus-Containing Polymeric Zwitterion: A Pioneering Bioresponsive Probe for P-31-Magnetic Resonance Imaging. Macromolecular Bioscience. WEINHEIM: Wiley-VCH, 2022, roč. 22, č. 5, s. 2100523-2100532. ISSN 1616-5187. Dostupné z: https://dx.doi.org/10.1002/mabi.202100523. |
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@article{2262445,
author = {Kracikova, Lucie and Ziolkowska, Natalia and Androvic, Ladislav and Klimankova, Iveta and Cerveny, David and Vit, Martin and Pompach, Petr and Konefal, Rafal and Janouskova, Olga and Hruby, Martin and Jirak, Daniel and Laga, Richard},
article_location = {WEINHEIM},
article_number = {5},
doi = {http://dx.doi.org/10.1002/mabi.202100523},
keywords = {P-31-MRI; MRI probes; polymer zwitterions; RAFT polymerization; ROS detection},
language = {eng},
issn = {1616-5187},
journal = {Macromolecular Bioscience},
title = {Phosphorus-Containing Polymeric Zwitterion: A Pioneering Bioresponsive Probe for P-31-Magnetic Resonance Imaging},
url = {https://onlinelibrary.wiley.com/doi/10.1002/mabi.202100523},
volume = {22},
year = {2022}
}
TY - JOUR
ID - 2262445
AU - Kracikova, Lucie - Ziolkowska, Natalia - Androvic, Ladislav - Klimankova, Iveta - Cerveny, David - Vit, Martin - Pompach, Petr - Konefal, Rafal - Janouskova, Olga - Hruby, Martin - Jirak, Daniel - Laga, Richard
PY - 2022
TI - Phosphorus-Containing Polymeric Zwitterion: A Pioneering Bioresponsive Probe for P-31-Magnetic Resonance Imaging
JF - Macromolecular Bioscience
VL - 22
IS - 5
SP - 2100523
EP - 2100523
PB - Wiley-VCH
SN - 16165187
KW - P-31-MRI
KW - MRI probes
KW - polymer zwitterions
KW - RAFT polymerization
KW - ROS detection
UR - https://onlinelibrary.wiley.com/doi/10.1002/mabi.202100523
N2 - P-31-magnetic resonance (MR) is an important diagnostic technique currently used for tissue metabolites assessing, but it also has great potential for visualizing the internal body structures. However, due to the low physiological level of phosphorus-containing biomolecules, precise imaging requires the administration of an exogenous probe. Herein, this work describes the synthesis and MR characterization of a pioneering metal-free P-31-MR probe based on phosphorus-containing polymeric zwitterion. The developed probe (pTMPC) is a well-defined water-soluble macromolecule characterized by a high content of naturally rare phosphorothioate groups providing a high-intensity P-31-MR signal clearly distinguishable from biological background both in vitro and in vitro. In addition, pTMPC can serve as a sensitive P-31-MR sensor of pathological conditions in vivo because it undergoes oxidation-induced structural changes in the presence of reactive oxygen species (ROS). Add to this the favorable H-1 and P-31 T-1/T-2 relaxation times and biocompatibility, pTMPC represents a conceptually new diagnostic, whose discovery opens up new possibilities in the field of P-31-MR spectroscopy and imaging.
ER -
KRACIKOVA, Lucie, Natalia ZIOLKOWSKA, Ladislav ANDROVIC, Iveta KLIMANKOVA, David CERVENY, Martin VIT, Petr POMPACH, Rafal KONEFAL, Olga JANOUSKOVA, Martin HRUBY, Daniel JIRAK a Richard LAGA. Phosphorus-Containing Polymeric Zwitterion: A Pioneering Bioresponsive Probe for P-31-Magnetic Resonance Imaging. \textit{Macromolecular Bioscience}. WEINHEIM: Wiley-VCH, 2022, roč.~22, č.~5, s.~2100523-2100532. ISSN~1616-5187. Dostupné z: https://dx.doi.org/10.1002/mabi.202100523.
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