Language impairment in Parkinson’s disease: fMRI study of
sentence reading comprehension

J 2023

Language impairment in Parkinson’s disease: fMRI study of sentence reading comprehension

NOVÁKOVÁ, Ľubomíra, Martin GAJDOŠ, Jana MARKOVA, Alice MARTINKOVICOVA, Zuzana KOSUTZKA et. al.

Základní údaje

Originální název

Language impairment in Parkinson’s disease: fMRI study of sentence reading comprehension

Autoři

NOVÁKOVÁ, Ľubomíra (703 Slovensko, domácí), Martin GAJDOŠ (203 Česká republika, domácí), Jana MARKOVA (703 Slovensko), Alice MARTINKOVICOVA (703 Slovensko), Zuzana KOSUTZKA (703 Slovensko), Jana SVANTNEROVA (703 Slovensko), Peter VALKOVIC (703 Slovensko), Cséfalvay ZSOLT (703 Slovensko) a Irena REKTOROVÁ (203 Česká republika, garant, domácí)

Vydání

Frontiers in aging neuroscience, LAUSANNE, FRONTIERS MEDIA SA, 2023, 1663-4365

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.800 v roce 2022

Kód RIV

RIV/00216224:14740/23:00130414

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.3389/fnagi.2023.1117473

UT WoS

000951311600001

Klíčová slova anglicky

Parkinson’s disease; language impairment; sentence reading comprehension; task fMRI; functional connectivity; striatum

Štítky

CF MAFIL, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 10. 2024 08:58, Mgr. Adéla Pešková

Anotace

V originále

Parkinson’s disease (PD) affects the language processes, with a significant impact on the patients’ daily communication. We aimed to describe specific alterations in the comprehension of syntactically complex sentences in patients with PD (PwPD) as compared to healthy controls (HC) and to identify the neural underpinnings of these deficits using a functional connectivity analysis of the striatum. A total of 20 patients PwPD and 15 HC participated in the fMRI study. We analyzed their performance of a Test of sentence comprehension (ToSC) adjusted for fMRI. A task-dependent functional connectivity analysis of the striatum was conducted using the psychophysiological interaction method (PPI). On the behavioral level, the PwPD scored significantly lower (mean sd: 77.3 12.6) in the total ToSC score than the HC did (mean sd: 86.6 8.0), p = 0.02, and the difference was also significant specifically for sentences with a noncanonical word order (PD-mean sd: 69.9 14.1, HC-mean sd: 80.2 11.5, p = 0.04). Using PPI, we found a statistically significant difference between the PwPD and the HC in connectivity from the right striatum to the supplementary motor area [SMA, (4 8 53)] for non-canonical sentences. This PPI connectivity was negatively correlated with the ToSC accuracy of non-canonical sentences in the PwPD. Our results showed disturbed sentence reading comprehension in the PwPD with altered task-dependent functional connectivity from the right striatum to the SMA, which supports the synchronization of the temporal and sequential aspects of language processing. The study revealed that subcorticalcortical networks (striatal-frontal loop) in PwPD are compromised, leading to impaired comprehension of syntactically complex sentences.

Návaznosti

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

NOVÁKOVÁ, Ľubomíra, Martin GAJDOŠ, Jana MARKOVA, Alice MARTINKOVICOVA, Zuzana KOSUTZKA, Jana SVANTNEROVA, Peter VALKOVIC, Cséfalvay ZSOLT a Irena REKTOROVÁ. Language impairment in Parkinson’s disease: fMRI study of sentence reading comprehension. Frontiers in aging neuroscience. LAUSANNE: FRONTIERS MEDIA SA, 2023, roč. 15, č. 15, s. 1-8. ISSN 1663-4365. Dostupné z: https://dx.doi.org/10.3389/fnagi.2023.1117473.

@article{2264797,
   author = {Nováková, Ľubomíra and Gajdoš, Martin and Markova, Jana and Martinkovicova, Alice and Kosutzka, Zuzana and Svantnerova, Jana and Valkovic, Peter and Zsolt, Cséfalvay and Rektorová, Irena},
   article_location = {LAUSANNE},
   article_number = {15},
   doi = {http://dx.doi.org/10.3389/fnagi.2023.1117473},
   keywords = {Parkinson’s disease; language impairment; sentence reading comprehension; task fMRI; functional connectivity; striatum},
   language = {eng},
   issn = {1663-4365},
   journal = {Frontiers in aging neuroscience},
   title = {Language impairment in Parkinson’s disease: fMRI study of sentence reading comprehension},
   url = {https://www.frontiersin.org/articles/10.3389/fnagi.2023.1117473},
   volume = {15},
   year = {2023}
}

TY  - JOUR
ID  - 2264797
AU  - Nováková, Ľubomíra - Gajdoš, Martin - Markova, Jana - Martinkovicova, Alice - Kosutzka, Zuzana - Svantnerova, Jana - Valkovic, Peter - Zsolt, Cséfalvay - Rektorová, Irena
PY  - 2023
TI  - Language impairment in Parkinson’s disease: fMRI study of sentence reading comprehension
JF  - Frontiers in aging neuroscience
VL  - 15
IS  - 15
SP  - 1-8
EP  - 1-8
PB  - FRONTIERS MEDIA SA
SN  - 16634365
KW  - Parkinson’s disease
KW  - language impairment
KW  - sentence reading comprehension
KW  - task fMRI
KW  - functional connectivity
KW  - striatum
UR  - https://www.frontiersin.org/articles/10.3389/fnagi.2023.1117473
N2  - Parkinson’s disease (PD) affects the language processes, with a significant impact on the patients’ daily communication. We aimed to describe specific alterations in the comprehension of syntactically complex sentences in patients with PD (PwPD) as compared to healthy controls (HC) and to identify the neural underpinnings of these deficits using a functional connectivity analysis of the striatum. A total of 20 patients PwPD and 15 HC participated in the fMRI study. We analyzed their performance of a Test of sentence comprehension (ToSC) adjusted for fMRI. A task-dependent functional connectivity analysis of the striatum was conducted using the psychophysiological interaction method (PPI). On the behavioral level, the PwPD scored significantly lower (mean sd: 77.3 12.6) in the total ToSC score than the HC did (mean sd: 86.6 8.0), p = 0.02, and the difference was also significant specifically for sentences with a noncanonical word order (PD-mean sd: 69.9 14.1, HC-mean sd: 80.2 11.5, p = 0.04). Using PPI, we found a statistically significant difference between the PwPD and the HC in connectivity from the right striatum to the supplementary motor area [SMA, (4 8 53)] for non-canonical sentences. This PPI connectivity was negatively correlated with the ToSC accuracy of non-canonical sentences in the PwPD. Our results showed disturbed sentence reading comprehension in the PwPD with altered task-dependent functional connectivity from the right striatum to the SMA, which supports the synchronization of the temporal and sequential aspects of language processing. The study revealed that subcorticalcortical networks (striatal-frontal loop) in PwPD are compromised, leading to impaired comprehension of syntactically complex sentences.
ER  -

NOVÁKOVÁ, Ľubomíra, Martin GAJDOŠ, Jana MARKOVA, Alice MARTINKOVICOVA, Zuzana KOSUTZKA, Jana SVANTNEROVA, Peter VALKOVIC, Cséfalvay ZSOLT a Irena REKTOROVÁ. Language impairment in Parkinson’s disease: fMRI study of sentence reading comprehension. \textit{Frontiers in aging neuroscience}. LAUSANNE: FRONTIERS MEDIA SA, 2023, roč.~15, č.~15, s.~1-8. ISSN~1663-4365. Dostupné z: https://dx.doi.org/10.3389/fnagi.2023.1117473.

Podrobný výpis o publikaci