Kinetics of D-lactate and ischemia-modified albumin after
abdominal aortic surgery and their ability to predict
intestinal ischemia

J 2023

Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia

TOMANDLOVÁ, Marie, Tomáš NOVOTNÝ, Robert STAFFA, Jindra SMUTNÁ, Tomáš KŘIVKA et. al.

Základní údaje

Originální název

Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia

Autoři

TOMANDLOVÁ, Marie (203 Česká republika, domácí), Tomáš NOVOTNÝ (203 Česká republika, domácí), Robert STAFFA (203 Česká republika, domácí), Jindra SMUTNÁ (203 Česká republika, domácí), Tomáš KŘIVKA (203 Česká republika, domácí), Peter KRUŽLIAK (703 Slovensko, domácí), Ondřej SLABÝ (203 Česká republika, domácí), Luboš KUBÍČEK (203 Česká republika, domácí), Robert VLACHOVSKÝ (203 Česká republika, domácí), Lenka RADOVÁ (203 Česká republika, domácí) a Josef TOMANDL (203 Česká republika, garant, domácí)

Vydání

Clinical Biochemistry, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2023, 0009-9120

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.800 v roce 2022

Kód RIV

RIV/00216224:14110/23:00134627

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.clinbiochem.2022.12.002

UT WoS

000923758200001

Klíčová slova anglicky

Acute intestinal ischemia; D -Lactate; Ischemia-modified albumin; Abdominal aortic aneurysm; Aortoiliac occlusive disease; Perioperative kinetics

Štítky

14110119, 14110121, 14110512, 14110513, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 3. 2024 10:50, Mgr. Tereza Miškechová

Anotace

V originále

Objectives: Acute intestinal ischemia is a severe complication of abdominal aortic surgery that is difficult to diagnose early and therefore to treat adequately and timely. In this study the perioperative kinetics of D-lactate and ischemia-modified albumin (IMA) are described and the predictive value of these markers for the early diagnosis of acute intestinal ischemia is assessed.Design & methods: This non-randomised, single-centre cohort study enrolled 50 patients with abdominal aortic aneurysm (AAA) and 30 patients with aortoiliac occlusive disease (AOID). Serum D-lactate and IMA were assessed pre-, intra-, and postoperatively at eight defined time points.Results: The highest serum D-lactate was at 6 h after complete declamping of the vascular graft. The highest predictive power of D-lactate was at 3 h after complete declamping (AUC 0.857). IMA was found to be higher in the AAA group in ischemic patients 10 min after complete declamping than in the AOID group. The highest predictive values of IMA were at 1 h after aortic cross-clamping (AUC 0.758) and 3 and 6 h after complete declamping (0.745 and 0.721, respectively). Moreover, the multivariate model with both markers at 3 h after complete declamping improved the detection of intestinal ischemia (AUC 0.894).Conclusions: Serum levels of IMA and D-lactate seem to be influential predictive markers for postoperative intestinal ischemia, especially after 3 h from complete declamping of vascular reconstruction.

Návaznosti

NV17-29701A, projekt VaV

Název: Ischémií modifikovaný albumin a cirkulující mikroRNA jako nové technologie k monitorování tkáňové ischémie po cévních rekonstrukcích na břišní aortě

Citovat

TOMANDLOVÁ, Marie, Tomáš NOVOTNÝ, Robert STAFFA, Jindra SMUTNÁ, Tomáš KŘIVKA, Peter KRUŽLIAK, Ondřej SLABÝ, Luboš KUBÍČEK, Robert VLACHOVSKÝ, Lenka RADOVÁ a Josef TOMANDL. Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia. Clinical Biochemistry. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2023, roč. 112, February 2023, s. 43-47. ISSN 0009-9120. Dostupné z: https://dx.doi.org/10.1016/j.clinbiochem.2022.12.002.

@article{2266100,
   author = {Tomandlová, Marie and Novotný, Tomáš and Staffa, Robert and Smutná, Jindra and Křivka, Tomáš and Kružliak, Peter and Slabý, Ondřej and Kubíček, Luboš and Vlachovský, Robert and Radová, Lenka and Tomandl, Josef},
   article_location = {OXFORD},
   article_number = {February 2023},
   doi = {http://dx.doi.org/10.1016/j.clinbiochem.2022.12.002},
   keywords = {Acute intestinal ischemia; D -Lactate; Ischemia-modified albumin; Abdominal aortic aneurysm; Aortoiliac occlusive disease; Perioperative kinetics},
   language = {eng},
   issn = {0009-9120},
   journal = {Clinical Biochemistry},
   title = {Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia},
   url = {https://www.sciencedirect.com/science/article/pii/S0009912022002715?via%3Dihub},
   volume = {112},
   year = {2023}
}

TY  - JOUR
ID  - 2266100
AU  - Tomandlová, Marie - Novotný, Tomáš - Staffa, Robert - Smutná, Jindra - Křivka, Tomáš - Kružliak, Peter - Slabý, Ondřej - Kubíček, Luboš - Vlachovský, Robert - Radová, Lenka - Tomandl, Josef
PY  - 2023
TI  - Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia
JF  - Clinical Biochemistry
VL  - 112
IS  - February 2023
SP  - 43-47
EP  - 43-47
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 00099120
KW  - Acute intestinal ischemia
KW  - D -Lactate
KW  - Ischemia-modified albumin
KW  - Abdominal aortic aneurysm
KW  - Aortoiliac occlusive disease
KW  - Perioperative kinetics
UR  - https://www.sciencedirect.com/science/article/pii/S0009912022002715?via%3Dihub
N2  - Objectives: Acute intestinal ischemia is a severe complication of abdominal aortic surgery that is difficult to diagnose early and therefore to treat adequately and timely. In this study the perioperative kinetics of D-lactate and ischemia-modified albumin (IMA) are described and the predictive value of these markers for the early diagnosis of acute intestinal ischemia is assessed.Design & methods: This non-randomised, single-centre cohort study enrolled 50 patients with abdominal aortic aneurysm (AAA) and 30 patients with aortoiliac occlusive disease (AOID). Serum D-lactate and IMA were assessed pre-, intra-, and postoperatively at eight defined time points.Results: The highest serum D-lactate was at 6 h after complete declamping of the vascular graft. The highest predictive power of D-lactate was at 3 h after complete declamping (AUC 0.857). IMA was found to be higher in the AAA group in ischemic patients 10 min after complete declamping than in the AOID group. The highest predictive values of IMA were at 1 h after aortic cross-clamping (AUC 0.758) and 3 and 6 h after complete declamping (0.745 and 0.721, respectively). Moreover, the multivariate model with both markers at 3 h after complete declamping improved the detection of intestinal ischemia (AUC 0.894).Conclusions: Serum levels of IMA and D-lactate seem to be influential predictive markers for postoperative intestinal ischemia, especially after 3 h from complete declamping of vascular reconstruction.
ER  -

TOMANDLOVÁ, Marie, Tomáš NOVOTNÝ, Robert STAFFA, Jindra SMUTNÁ, Tomáš KŘIVKA, Peter KRUŽLIAK, Ondřej SLABÝ, Luboš KUBÍČEK, Robert VLACHOVSKÝ, Lenka RADOVÁ a Josef TOMANDL. Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia. \textit{Clinical Biochemistry}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2023, roč.~112, February 2023, s.~43-47. ISSN~0009-9120. Dostupné z: https://dx.doi.org/10.1016/j.clinbiochem.2022.12.002.

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