WEISEROVA, Zuzana, Viola ZENTRICHOVA, Denisa MEDKOVA, Jana BLAHOVA, Aleš FRANC, Michaela GARAJOVA, Jan MARES, Eva POSTULKOVA, Roman FRANEK, Martin PSENICKA, Petr MARSALEK a Zdenka SVOBODOVA. Use of all-male triploid population of zebrafish (Danio rerio) for evaluation of 17 alpha-ethinylestradiol effects. Neuroendocrinology letters. MUNSBACH: MAGHIRA & MAAS PUBLICATIONS, 2022, roč. 43, č. 5, s. 281-290. ISSN 0172-780X. |
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@article{2270797, author = {Weiserova, Zuzana and Zentrichova, Viola and Medkova, Denisa and Blahova, Jana and Franc, Aleš and Garajova, Michaela and Mares, Jan and Postulkova, Eva and Franek, Roman and Psenicka, Martin and Marsalek, Petr and Svobodova, Zdenka}, article_location = {MUNSBACH}, article_number = {5}, keywords = {EE2; feed contamination; oral intake; vitellogenin; xenoestrogen testing}, language = {eng}, issn = {0172-780X}, journal = {Neuroendocrinology letters}, title = {Use of all-male triploid population of zebrafish (Danio rerio) for evaluation of 17 alpha-ethinylestradiol effects}, url = {https://www.nel.edu/userfiles/articlesnew/1674499217_43_5_weiserova_281-pdf.pdf}, volume = {43}, year = {2022} }
TY - JOUR ID - 2270797 AU - Weiserova, Zuzana - Zentrichova, Viola - Medkova, Denisa - Blahova, Jana - Franc, Aleš - Garajova, Michaela - Mares, Jan - Postulkova, Eva - Franek, Roman - Psenicka, Martin - Marsalek, Petr - Svobodova, Zdenka PY - 2022 TI - Use of all-male triploid population of zebrafish (Danio rerio) for evaluation of 17 alpha-ethinylestradiol effects JF - Neuroendocrinology letters VL - 43 IS - 5 SP - 281-290 EP - 281-290 PB - MAGHIRA & MAAS PUBLICATIONS SN - 0172780X KW - EE2 KW - feed contamination KW - oral intake KW - vitellogenin KW - xenoestrogen testing UR - https://www.nel.edu/userfiles/articlesnew/1674499217_43_5_weiserova_281-pdf.pdf N2 - OBJECTIVES: We tested the toxicity of ethinylestradiol, a semisynthetic estrogen used in oral contraceptives, on all-male triploid zebrafish using commercial feeds and three different doses concentrations. We aimed to determine whether ethinylestradiol peroral administration resulted in vitellogenin production and whether all-male triploid zebrafish could serve as a model species for xenoestrogen testing. METHODS: The actual concentrations of 17 alpha-ethinylestradiol were 0.0035 (low); 0.0315 (medium) and 0.365 (high) mu g/g. Positive control represented commercial feeds containing 0.0465 mu g/g of beta-estradiol. The experiment lasted 8 weeks. RESULTS: Our results indicate that 17 alpha-ethinylestradiol consumption does induce vitellogenin production in triploid zebrafish. CONCLUSIONS: The simple presence of vitellogenin is a definite symptom indicative of the potential for such changes due to the action of estrogenic substances. As such, this experiment has shown that the use of all-male triploid zebrafish populations, rather than the mixed-sex populations of other species previously used, could serve as a suitable alternative model population for controlled testing of the effects of xenoestrogens on fish. ER -
WEISEROVA, Zuzana, Viola ZENTRICHOVA, Denisa MEDKOVA, Jana BLAHOVA, Aleš FRANC, Michaela GARAJOVA, Jan MARES, Eva POSTULKOVA, Roman FRANEK, Martin PSENICKA, Petr MARSALEK a Zdenka SVOBODOVA. Use of all-male triploid population of zebrafish (Danio rerio) for evaluation of 17 alpha-ethinylestradiol effects. \textit{Neuroendocrinology letters}. MUNSBACH: MAGHIRA \&{} MAAS PUBLICATIONS, 2022, roč.~43, č.~5, s.~281-290. ISSN~0172-780X.
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