| ORAL, Cagatay M., Martina USSIA, Mario URSO, Jiří SALÁT, Adam NOVOBILSKY, Michal STEFANIK, Daniel RŮŽEK a Martin PUMERA. Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract. Advanced Healthcare Materials. Wiley, 2023, roč. 12, č. 8, s. 1-9. ISSN 2192-2640. Dostupné z: https://dx.doi.org/10.1002/adhm.202202682. |
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@article{2272057,
author = {Oral, Cagatay M. and Ussia, Martina and Urso, Mario and Salát, Jiří and Novobilsky, Adam and Stefanik, Michal and Růžek, Daniel and Pumera, Martin},
article_number = {8},
doi = {http://dx.doi.org/10.1002/adhm.202202682},
keywords = {computed tomography; gastrointestinal tract; magnetic actuation; medical imaging; nanomotors; nanoswimmers; tracking},
language = {eng},
issn = {2192-2640},
journal = {Advanced Healthcare Materials},
title = {Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract},
url = {https://doi.org/10.1002/adhm.202202682},
volume = {12},
year = {2023}
}
TY - JOUR
ID - 2272057
AU - Oral, Cagatay M. - Ussia, Martina - Urso, Mario - Salát, Jiří - Novobilsky, Adam - Stefanik, Michal - Růžek, Daniel - Pumera, Martin
PY - 2023
TI - Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract
JF - Advanced Healthcare Materials
VL - 12
IS - 8
SP - 1-9
EP - 1-9
PB - Wiley
SN - 21922640
KW - computed tomography
KW - gastrointestinal tract
KW - magnetic actuation
KW - medical imaging
KW - nanomotors
KW - nanoswimmers
KW - tracking
UR - https://doi.org/10.1002/adhm.202202682
N2 - Magnetic nanorobots offer wireless navigation capability in hard-to-reach areas of the human body for targeted therapy and diagnosis. Though in vivo imaging is required for guidance of the magnetic nanorobots toward the target areas, most of the imaging techniques are inadequate to reveal the potential locomotion routes. This work proposes the use of radiopaque magnetic nanorobots along with microcomputed tomography (microCT) for localized in vivo imaging applications. The nanorobots consist of a contrast agent, barium sulfate (BaSO4), magnetized by the decoration of magnetite (Fe3O4) particles. The magnetic features lead to actuation under rotating magnetic fields and enable precise navigation in a microfluidic channel used to simulate confined spaces of the body. In this channel, the intrinsic radiopacity of the nanorobots also provides the possibility to reveal the internal structures by X-ray contrast. Furthermore, in vitro analysis indicates nontoxicity of the nanorobots. In vivo experiments demonstrate localization of the nanorobots in a specific part of the gastrointestinal (GI) tract upon the influence of the magnetic field, indicating the efficient control even in the presence of natural peristaltic movements. The nanorobots reported here highlight that smart nanorobotic contrast agents can improve the current imaging-based diagnosis techniques by providing untethered controllability in vivo.
ER -
ORAL, Cagatay M., Martina USSIA, Mario URSO, Jiří SALÁT, Adam NOVOBILSKY, Michal STEFANIK, Daniel RŮŽEK a Martin PUMERA. Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract. \textit{Advanced Healthcare Materials}. Wiley, 2023, roč.~12, č.~8, s.~1-9. ISSN~2192-2640. Dostupné z: https://dx.doi.org/10.1002/adhm.202202682.
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