MACKŮ, Jan, Kateřina KUBOVÁ, Martina ČUBOVÁ URBANOVÁ, Jiří BRUS, Jan MUSELÍK, Daniela HLAVATÁ, Miroslava PAVELKOVÁ, Sylvie PAVLOKOVÁ, Jakub VYSLOUŽIL and David VETCHÝ. Stability of thymol self-emulsifying chitosan pellets for the potential treatment of intestinal mucosa. In 4th European Conference on Pharmaceutics -20&21 March 2023, Marseille – France. 2023.
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Basic information
Original name Stability of thymol self-emulsifying chitosan pellets for the potential treatment of intestinal mucosa
Name in Czech Stabilita samoemulgujících chitosanových pelet s obsahem thymolu pro potenciální léčbu střevní sliznice
Authors MACKŮ, Jan (203 Czech Republic, belonging to the institution), Kateřina KUBOVÁ (203 Czech Republic, guarantor, belonging to the institution), Martina ČUBOVÁ URBANOVÁ (203 Czech Republic), Jiří BRUS (203 Czech Republic), Jan MUSELÍK (203 Czech Republic, belonging to the institution), Daniela HLAVATÁ (203 Czech Republic, belonging to the institution), Miroslava PAVELKOVÁ (203 Czech Republic, belonging to the institution), Sylvie PAVLOKOVÁ (203 Czech Republic, belonging to the institution), Jakub VYSLOUŽIL (203 Czech Republic, belonging to the institution) and David VETCHÝ (203 Czech Republic, belonging to the institution).
Edition 4th European Conference on Pharmaceutics -20&21 March 2023, Marseille – France, 2023.
Other information
Original language English
Type of outcome Presentations at conferences
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization unit Faculty of Pharmacy
Keywords (in Czech) thymol; pevné samoemulgující systémy; ssNMR; pelety; stabilita
Keywords in English thymol; solid self-emulsifying systems; ssNMR; pellets; stability
Tags rivok, ÚFT
Tags International impact
Changed by Changed by: doc. PharmDr. Kateřina Kubová, Ph.D., učo 233198. Changed: 14/4/2023 14:58.
Abstract
The aim of the presented experimental study was to determine the stability of the Eugragit®L-coated chitosan/ Neusilin®US2 pellets containing thymol SEDDS. The first results confirmed the stability of uncoated self-emulsifying pellets with thymol in a half-year stability study in both storage conditions. On the contrary, the enteric-coated pellet formulation was stable only in the condition 25 °C/ 60 RH. Moreover, a mild deterioration of dissolution characteristics was reported.
Abstract (in Czech)
Cílem předložené experimentální studie bylo stanovit stabilitu pelet na bázi chitosanu a Neusilinu®US2 obalených Eugragitem®L, které obsahovaly SEDDS s thymolem. První výsledky potvrdily stabilitu neobalených samoemulgujících pelet v půlroční stabilitní studii v obou skladovacích podmínkách. Naopak, pelety obalené enterosolventním obalem byly stabilní pouze v podmínkách 25 °C/ 60 RH. Navíc bylo zaznamenáno mírné zhoršení disolučních vlastností.
Links
GA22-03187S, research and development projectName: Racionální design částicových polysacharidových systémů pro přívod léčiv s širokým spekterem biologické aktivity k terapii sliznic (Acronym: 22-03187S)
Investor: Czech Science Foundation
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