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@proceedings{2277918,
author = {Peštálová, Andrea and Pavloková, Sylvie and Gajdziok, Jan},
booktitle = {Student scientific conference MUNI PHARM 2023},
keywords = {microparticles; spray drying; ciprofloxacin; cystic fibrosis},
language = {eng},
title = {Spray-dried microparticles containing ciprofloxacin for pulmonary delivery},
year = {2023}
}
TY - CONF
ID - 2277918
AU - Peštálová, Andrea - Pavloková, Sylvie - Gajdziok, Jan
PY - 2023
TI - Spray-dried microparticles containing ciprofloxacin for pulmonary delivery
KW - microparticles
KW - spray drying
KW - ciprofloxacin
KW - cystic fibrosis
N2 - Inhalation therapy of cystic fibrosis using a dry powder inhaler (DPI) is currently being studied in many clinical trials. One possible treatment option is the administration of fluroqinolones in the treatment of P. aeruginosa infections and have been proven to reduce the bacterial load in the lungs and improve patients’ lung function. In order for antibiotic therapy to be effective, the formulation should focus on the parameters particles should have, especially their size and shape, porosity or aerosolisation properties. For the formulation of dry powders, the most common are spray technologies and also the addition of excipients such as porogens or substances from the amino acid group can modify the resulting properties. The aim was to optimize the drying conditions to produce aerodynamically suitable particles. In the next step, particles containing ciprofloxacin were formulated. The resulting particles were evaluated in terms of morphology, flow properties and geometric or aerodynamic diameter respectively.
ER -
PEŠTÁLOVÁ, Andrea, Sylvie PAVLOKOVÁ a Jan GAJDZIOK. Spray-dried microparticles containing ciprofloxacin for pulmonary delivery. In \textit{Student scientific conference MUNI PHARM 2023}. 2023.
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