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@article{2279453, author = {Hillmen, Peter and Eichhorst, Barbara and Brown, Jennifer R and Lamanna, Nicole and Brien, Susan M and Tam, Constantine S and Qiu, Lugui and Kazmierczak, Maciej and Zhou, Keshu and Simkovic, Martin and Mayer, Jiří and GillespieandTwardy, Amanda and Shadman, Mazyar and Ferrajoli, Alessandra and Ganly, Peter S and Weinkove, Robert and Grosicki, Sebastian and Mital, Andrzej and Robak, Tadeusz and Osterborg, Anders and Yimer, Habte A and Salmi, Tommi and Ji, Meng and Yecies, Jessica and Idoine, Adam and Wu, Kenneth and Huang, Jane and Jurczak, Wojciech}, article_location = {United States}, article_number = {5}, doi = {http://dx.doi.org/10.1200/JCO.22.00510}, keywords = {Zanubrutinib; Ibrutinib; Relapsed/Refractory Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma}, language = {eng}, issn = {0732-183X}, journal = {Journal of clinical oncology}, title = {Zanubrutinib Versus Ibrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: Interim Analysis of a Randomized Phase III Trial}, url = {https://ascopubs.org/doi/10.1200/JCO.22.00510}, volume = {41}, year = {2023} }
TY - JOUR ID - 2279453 AU - Hillmen, Peter - Eichhorst, Barbara - Brown, Jennifer R - Lamanna, Nicole - Brien, Susan M - Tam, Constantine S - Qiu, Lugui - Kazmierczak, Maciej - Zhou, Keshu - Simkovic, Martin - Mayer, Jiří - Gillespie-Twardy, Amanda - Shadman, Mazyar - Ferrajoli, Alessandra - Ganly, Peter S - Weinkove, Robert - Grosicki, Sebastian - Mital, Andrzej - Robak, Tadeusz - Osterborg, Anders - Yimer, Habte A - Salmi, Tommi - Ji, Meng - Yecies, Jessica - Idoine, Adam - Wu, Kenneth - Huang, Jane - Jurczak, Wojciech PY - 2023 TI - Zanubrutinib Versus Ibrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: Interim Analysis of a Randomized Phase III Trial JF - Journal of clinical oncology VL - 41 IS - 5 SP - "1035"-"+" EP - "1035"-"+" PB - LIPPINCOTT WILLIAMS & WILKINS SN - 0732183X KW - Zanubrutinib KW - Ibrutinib KW - Relapsed/Refractory Chronic Lymphocytic Leukemia KW - Small Lymphocytic Lymphoma UR - https://ascopubs.org/doi/10.1200/JCO.22.00510 N2 - PURPOSE Zanubrutinib is a potent, irreversible next-generation Bruton tyrosine kinase (BTK) inhibitor designed to maximize BTK occupancy and minimize off-target kinase inhibition. We hypothesized that complete/sustained BTK occupancy may improve efficacy outcomes and increased BTK specificity may minimize off-target inhibition-related toxicities.PATIENTS AND METHODS ALPINE (ClinicalTrials.gov identifier: ) is a global, randomized, open-label phase III study of zanubrutinib versus ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia. The primary end point was investigator-assessed overall response rate (ORR). The preplanned interim analysis was scheduled approximately 12 months after the first 415 patients were enrolled.RESULTS Between November 1, 2018, and December 14, 2020, 652 patients were enrolled. We present the interim analysis of the first 415 enrolled patients randomly assigned to receive zanubrutinib (n = 207) or ibrutinib (n = 208). At 15 months of median follow-up, ORR (partial or complete response) was significantly higher with zanubrutinib (78.3%; 95% CI, 72.0 to 83.7) versus ibrutinib (62.5%; 95% CI, 55.5 to 69.1; two-sided P < .001). ORR was higher with zanubrutinib versus ibrutinib in subgroups with del(17p)/TP53 mutations (80.5% v 50.0%) and del(11q) (83.6% v 69.1%); 12-month progression-free survival in all patients was higher with zanubrutinib (94.9%) versus ibrutinib (84.0%; hazard ratio, 0.40; 95% CI, 0.23 to 0.69). Atrial fibrillation rate was significantly lower with zanubrutinib versus ibrutinib (2.5% v 10.1%; two-sided P = .001). Rates of cardiac events, major hemorrhages, and adverse events leading to treatment discontinuation/death were lower with zanubrutinib.CONCLUSION Zanubrutinib had a significantly higher ORR, lower atrial fibrillation rate, and improved progression-free survival and overall cardiac safety profile versus ibrutinib. These data support improved efficacy/safety outcomes with selective BTK inhibition. ER -
HILLMEN, Peter, Barbara EICHHORST, Jennifer R BROWN, Nicole LAMANNA, Susan M BRIEN, Constantine S TAM, Lugui QIU, Maciej KAZMIERCZAK, Keshu ZHOU, Martin SIMKOVIC, Jiří MAYER, Amanda GILLESPIE-TWARDY, Mazyar SHADMAN, Alessandra FERRAJOLI, Peter S GANLY, Robert WEINKOVE, Sebastian GROSICKI, Andrzej MITAL, Tadeusz ROBAK, Anders OSTERBORG, Habte A YIMER, Tommi SALMI, Meng JI, Jessica YECIES, Adam IDOINE, Kenneth WU, Jane HUANG a Wojciech JURCZAK. Zanubrutinib Versus Ibrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: Interim Analysis of a Randomized Phase III Trial. \textit{Journal of clinical oncology}. United States: LIPPINCOTT WILLIAMS \&{} WILKINS, 2023, roč.~41, č.~5, s.~''1035''-''+'', 12 s. ISSN~0732-183X. Dostupné z: https://dx.doi.org/10.1200/JCO.22.00510.
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