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@article{2279583,
author = {Smolková, Denisa and Čmelík, Richard and Lavická, Jana},
article_number = {June},
doi = {http://dx.doi.org/10.1016/j.trac.2023.117068},
keywords = {Capillary electrophoresis; Derivatization; Fluorescence; Glycans; Glycomics; Labeling; Mass spectrometry; Oligosaccharides},
language = {eng},
issn = {0165-9936},
journal = {TrAC Trends in Analytical Chemistry},
title = {Labeling strategies for analysis of oligosaccharides and glycans by capillary electrophoresis},
url = {https://doi.org/10.1016/j.trac.2023.117068},
volume = {163},
year = {2023}
}
TY - JOUR
ID - 2279583
AU - Smolková, Denisa - Čmelík, Richard - Lavická, Jana
PY - 2023
TI - Labeling strategies for analysis of oligosaccharides and glycans by capillary electrophoresis
JF - TrAC Trends in Analytical Chemistry
VL - 163
IS - June
SP - 1-9
EP - 1-9
PB - Elsevier B.V.
SN - 01659936
KW - Capillary electrophoresis
KW - Derivatization
KW - Fluorescence
KW - Glycans
KW - Glycomics
KW - Labeling
KW - Mass spectrometry
KW - Oligosaccharides
UR - https://doi.org/10.1016/j.trac.2023.117068
N2 - Capillary electrophoresis represents a powerful separation technique that has been widely accepted in oligosaccharide and glycan analysis. However, due to their low electrophoretic mobility as well as the lack of chromophore or fluorophore in their native structure, appropriate modification of the saccharide molecule is required before separation and detection. In this review, we summarize the labeling strategies used for oligosaccharide/glycan analysis followed by electrophoretic separation published between 2010 and mid-2022. The review is divided by the labeling mechanism and part of the saccharide molecule used for modification. Although most labeling for CE-based applications is done with 8-aminopyrene-1,3,6-trisulfonic acid trisodium salt, we have also summarized less common, rare, and very recently developed tags with applicability in glycomics.
ER -
SMOLKOVÁ, Denisa, Richard ČMELÍK a Jana LAVICKÁ. Labeling strategies for analysis of oligosaccharides and glycans by capillary electrophoresis. \textit{TrAC Trends in Analytical Chemistry}. Elsevier B.V., 2023, roč.~163, June, s.~1-9. ISSN~0165-9936. Dostupné z: https://dx.doi.org/10.1016/j.trac.2023.117068.
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