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@article{2281360, author = {Nemejcova, Kristyna and Bartu Kendall, Michaela and Michalkova, Romana and Drozenova, Jana and Fabian, Pavel and Fadare, Oluwole and Hausnerová, Jitka and Laco, Jan and Matej, Radoslav and Mehes, Gabor and Singh, Naveena and Stolnicu, Simona and Skapa, Petr and Svajdler, Marian and Struzinska, Ivana and Cibula, David and Kocian, Roman and Lax, Sigurd F. and McCluggage, W Glenn and Dundr, Pavel}, article_location = {LONDON}, article_number = {1}, doi = {http://dx.doi.org/10.1186/s13000-023-01300-4}, keywords = {IMP2; IMP3; Ovarian carcinoma; Immunohistochemistry}, language = {eng}, issn = {1746-1596}, journal = {Diagnostic Pathology}, title = {A comprehensive immunohistochemical analysis of IMP2 and IMP3 in 542 cases of ovarian tumors}, url = {https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-023-01300-4}, volume = {18}, year = {2023} }
TY - JOUR ID - 2281360 AU - Nemejcova, Kristyna - Bartu Kendall, Michaela - Michalkova, Romana - Drozenova, Jana - Fabian, Pavel - Fadare, Oluwole - Hausnerová, Jitka - Laco, Jan - Matej, Radoslav - Mehes, Gabor - Singh, Naveena - Stolnicu, Simona - Skapa, Petr - Svajdler, Marian - Struzinska, Ivana - Cibula, David - Kocian, Roman - Lax, Sigurd F. - McCluggage, W Glenn - Dundr, Pavel PY - 2023 TI - A comprehensive immunohistochemical analysis of IMP2 and IMP3 in 542 cases of ovarian tumors JF - Diagnostic Pathology VL - 18 IS - 1 SP - 1-10 EP - 1-10 PB - BMC SN - 17461596 KW - IMP2 KW - IMP3 KW - Ovarian carcinoma KW - Immunohistochemistry UR - https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-023-01300-4 N2 - BackgroundIMP2 and IMP3 are mRNA binding proteins involved in carcinogenesis. We examined a large cohort of ovarian tumors with the aim to assess the value of IMP2 and IMP3 for differential diagnosis, and to assess their prognostic significance.MethodsImmunohistochemical analyses with antibodies against IMP2 and IMP3 were performed on 554 primary ovarian tumors including 114 high grade serous carcinomas, 100 low grade serous carcinomas, 124 clear cell carcinomas, 54 endometrioid carcinomas, 34 mucinous carcinomas, 75 mucinous borderline tumors, and 41 serous borderline tumors (micropapillary variant). The associations of overall positivity with clinicopathological characteristics were evaluated using the chi-squared test or Fisher's Exact test.ResultsWe found IMP2 expression (in more than 5% of tumor cells) in nearly all cases of all tumor types, so the prognostic meaning could not be analyzed. The positive IMP3 expression (in more than 5% of tumor cells) was most common in mucinous carcinomas (82%) and mucinous borderline tumors (81%), followed by high grade serous (67%) and clear cell carcinomas (67%). The expression was less frequent in endometrioid carcinomas (39%), low grade serous carcinomas (23%), and micropapillary variant of serous borderline tumors (20%). Prognostic significance of IMP3 could be evaluated only in low grade serous carcinomas in the case of relapse-free survival, where negative cases showed better RFS (p = 0.033).ConclusionConcerning differential diagnosis our results imply that despite the differences in expression in the different ovarian tumor types, the practical value for diagnostic purposes is limited. Contrary to other solid tumors, we did not find prognostic significance of IMP3 in ovarian cancer, with the exception of RFS in low grade serous carcinomas. However, the high expression of IMP2 and IMP3 could be of predictive value in ovarian carcinomas since IMP proteins are potential therapeutical targets. ER -
NEMEJCOVA, Kristyna, Michaela BARTU KENDALL, Romana MICHALKOVA, Jana DROZENOVA, Pavel FABIAN, Oluwole FADARE, Jitka HAUSNEROVÁ, Jan LACO, Radoslav MATEJ, Gabor MEHES, Naveena SINGH, Simona STOLNICU, Petr SKAPA, Marian SVAJDLER, Ivana STRUZINSKA, David CIBULA, Roman KOCIAN, Sigurd F. LAX, W Glenn MCCLUGGAGE a Pavel DUNDR. A comprehensive immunohistochemical analysis of IMP2 and IMP3 in 542 cases of ovarian tumors. \textit{Diagnostic Pathology}. LONDON: BMC, 2023, roč.~18, č.~1, s.~1-10. ISSN~1746-1596. Dostupné z: https://dx.doi.org/10.1186/s13000-023-01300-4.
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