Driver and actionable mutations in younger patients with lung
cancer-are we searching properly?

J 2023

Driver and actionable mutations in younger patients with lung cancer-are we searching properly?

BRATOVÁ, Monika; Kristián BRAT; Zdeněk PAVLOVSKÝ; Jiří ŠÁNA; Ondřej SLABÝ et al.

Základní údaje

Originální název

Driver and actionable mutations in younger patients with lung cancer-are we searching properly?

Autoři

BRATOVÁ, Monika; Kristián BRAT; Zdeněk PAVLOVSKÝ; Jiří ŠÁNA a Ondřej SLABÝ

Vydání

Biomedical Papers, Olomouc: Palacky University, Olomouc, Palacky University, 2023, 1213-8118

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30203 Respiratory systems

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 0.700

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/23:00130746

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

lung cancer; young patient; driver; mutation

Štítky

14110215, 14110513, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 9. 2023 09:36, Mgr. Tereza Miškechová

Anotace

V originále

Aims.The authors focused on a group of young lung cancer patients with the aim of better understanding the mechanisms of tumor pathogenesis in these patients and search for potential targetable mutations.Methods. We collected retrospective data on patients under 40 years diagnosed with lung cancer (NSCLC or small-cell lung cancer) from 2011-2020 at the Department of Respiratory Diseases, University Hospital Brno, Czech Republic. Tumor tissue of these patients was analysed by next-generation sequencing (NGS, a panel of 550 variants in 19 genes). Demographic characteristics, smoking history, histology, molecular-genetic results and clinical stage of the disesase were recorded in all eligible patients from accessible medical databases.Results. Of 17 identified patients in only 8 cases was successful NGS carried out due to lack of sufficient good quality material in the other cases. The most frequently found molecular genetic changes were EGFR, RICTOR and HER2 amplification and MET and FGFR1 amplification. In addition, we found rare pathogenic variants in BRAF and PIK3CA genes. Actionable variants were detected in 75% patients.Conclusion. We detected very frequent driver and potentially actionable alterations in young patients with lung cancer. This suggests different mechanisms of carcinogenesis in these patients and indicates that they might benefit more from a specific approach than older lung cancer patients.

Návaznosti

LX22NPO5102, projekt VaV

Název: Národní ústav pro výzkum rakoviny (Akronym: NÚVR)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro výzkum rakoviny, 5.1 EXCELES

Přiložené soubory

Driver_and_actionable_mutations_in_younger_patients_with_lung_cancer-are_we_searching_properly.pdf

Citovat

BRATOVÁ, Monika; Kristián BRAT; Zdeněk PAVLOVSKÝ; Jiří ŠÁNA a Ondřej SLABÝ. Driver and actionable mutations in younger patients with lung cancer-are we searching properly? Biomedical Papers, Olomouc: Palacky University. Olomouc: Palacky University, 2023, roč. 167, č. 2, s. 152-156. ISSN 1213-8118. Dostupné z: https://doi.org/10.5507/bp.2023.012.

@article{2281457,
   author = {Bratová, Monika and Brat, Kristián and Pavlovský, Zdeněk and Šána, Jiří and Slabý, Ondřej},
   article_location = {Olomouc},
   article_number = {2},
   doi = {https://doi.org/10.5507/bp.2023.012},
   keywords = {lung cancer; young patient; driver; mutation},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers, Olomouc: Palacky University},
   title = {Driver and actionable mutations in younger patients with lung cancer-are we searching properly?},
   url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3379},
   volume = {167},
   year = {2023}
}

TY  - JOUR
ID  - 2281457
AU  - Bratová, Monika - Brat, Kristián - Pavlovský, Zdeněk - Šána, Jiří - Slabý, Ondřej
PY  - 2023
TI  - Driver and actionable mutations in younger patients with lung cancer-are we searching properly?
JF  - Biomedical Papers, Olomouc: Palacky University
VL  - 167
IS  - 2
SP  - 152-156
EP  - 152-156
PB  - Palacky University
SN  - 12138118
KW  - lung cancer
KW  - young patient
KW  - driver
KW  - mutation
UR  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3379
N2  - Aims.The authors focused on a group of young lung cancer patients with the aim of better understanding the mechanisms of tumor pathogenesis in these patients and search for potential targetable mutations.Methods. We collected retrospective data on patients under 40 years diagnosed with lung cancer (NSCLC or small-cell lung cancer) from 2011-2020 at the Department of Respiratory Diseases, University Hospital Brno, Czech Republic. Tumor tissue of these patients was analysed by next-generation sequencing (NGS, a panel of 550 variants in 19 genes). Demographic characteristics, smoking history, histology, molecular-genetic results and clinical stage of the disesase were recorded in all eligible patients from accessible medical databases.Results. Of 17 identified patients in only 8 cases was successful NGS carried out due to lack of sufficient good quality material in the other cases. The most frequently found molecular genetic changes were EGFR, RICTOR and HER2 amplification and MET and FGFR1 amplification. In addition, we found rare pathogenic variants in BRAF and PIK3CA genes. Actionable variants were detected in 75% patients.Conclusion. We detected very frequent driver and potentially actionable alterations in young patients with lung cancer. This suggests different mechanisms of carcinogenesis in these patients and indicates that they might benefit more from a specific approach than older lung cancer patients.
ER  -

BRATOVÁ, Monika; Kristián BRAT; Zdeněk PAVLOVSKÝ; Jiří ŠÁNA a Ondřej SLABÝ. Driver and actionable mutations in younger patients with lung cancer-are we searching properly? \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, 2023, roč.~167, č.~2, s.~152-156. ISSN~1213-8118. Dostupné z: https://doi.org/10.5507/bp.2023.012.

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