ŠŤASTNÁ, Nela, Kristián BRAT, Lukáš HOMOLA, Audun OS and Dagmar BRANČÍKOVÁ. Increasing incidence rate of breast cancer in cystic fibrosis-relationship between pathogenesis, oncogenesis and prediction of the treatment effect in the context of worse clinical outcome and prognosis of cystic fibrosis due to estrogens. Orphanet Journal of Rare Diseases. London: England, 2023, vol. 18, No 1, p. 1-7. ISSN 1750-1172. Available from: https://dx.doi.org/10.1186/s13023-023-02671-z.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Increasing incidence rate of breast cancer in cystic fibrosis-relationship between pathogenesis, oncogenesis and prediction of the treatment effect in the context of worse clinical outcome and prognosis of cystic fibrosis due to estrogens
Authors ŠŤASTNÁ, Nela (203 Czech Republic, guarantor, belonging to the institution), Kristián BRAT (703 Slovakia, belonging to the institution), Lukáš HOMOLA (203 Czech Republic, belonging to the institution), Audun OS and Dagmar BRANČÍKOVÁ (203 Czech Republic, belonging to the institution).
Edition Orphanet Journal of Rare Diseases, London, England, 2023, 1750-1172.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30203 Respiratory systems
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.700 in 2022
RIV identification code RIV/00216224:14110/23:00130751
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1186/s13023-023-02671-z
UT WoS 000956257500001
Keywords in English Cystic fibrosis; Breast cancer; Estrogens; Anticancer treatment; CFTR modulator therapy
Tags 14110212, 14110215, 14110318, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 10/5/2023 14:13.
Abstract
Cystic fibrosis (CF) is the most common genetic disease in the Caucasion population. Thanks to the CFTR modulators therapy, life expectancy will significantly improve. New therapeutic challenges can be expected, including diseases associated with ageing and higher incidence of cancer, as evidenced by recent epidemiological studies. The increasing incidence of tumors includes also breast cancer. The risk of breast cancer is higher in CF patients compared to the general population. Sex hormones, especially estrogens, also affect on the pathophysiology and immunology of the CF. Previous research, has demonstrated unequivocal survival rates for female CF patients compared to their male counterparts. Is demonstrated, that chemotherapy used for breast cancer affects the CFTR channel and CFTR modulator therapy has frequent side effects on breast tissue. In this review, we focus on the effects of female sex hormones on CF disease, pathophysiological relationships between CF and breast cancer, and the impact of antitumor treatment on both, malignant disease and CF. The potential for further investigation is also discussed.
PrintDisplayed: 29/6/2024 04:27