Effect of selected cardiovascular factors on mortality in
patients with ST-segment elevation myocardial infarction
treated with primary coronary intervention.

J 2023

Effect of selected cardiovascular factors on mortality in patients with ST-segment elevation myocardial infarction treated with primary coronary intervention.

KOMOROVÁ, Zuzana, Jan MÁCHAL, Ladislav GROCH, Lenka ŠPINAROVÁ, Karel LÁBR et. al.

Základní údaje

Originální název

Effect of selected cardiovascular factors on mortality in patients with ST-segment elevation myocardial infarction treated with primary coronary intervention.

Autoři

KOMOROVÁ, Zuzana (703 Slovensko, domácí), Jan MÁCHAL (203 Česká republika, domácí), Ladislav GROCH (203 Česká republika, domácí), Lenka ŠPINAROVÁ (203 Česká republika, domácí) a Karel LÁBR (203 Česká republika, garant, domácí)

Vydání

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, BRATISLAVA, AEPRESS SRO, 2023, 0006-9248

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.500 v roce 2022

Kód RIV

RIV/00216224:14110/23:00130763

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4149/BLL_2023_064

UT WoS

000994256900003

Klíčová slova anglicky

myocardial infarction; pimary coronary intervention; shock; mortality; cardio-specific markers

Štítky

14110115, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 6. 2023 13:44, Mgr. Tereza Miškechová

Anotace

V originále

OBJECTIVE: This work was aimed at analyzing in-hospital, 30-day and 1-year mortality rates, impact of selected cardiovascular factors on mortality of patients with ST-segment elevation myocardial infarction (STEMI) manifested on electrocardiogram (ECG) and treated by the percutaneous coronary intervention (PCI) at our cardiac center, comparing the subgroup of non-shock (survivors and deceased) patients after STEMI and evaluating how these patients differ from each other. METHODS: In total, 270 patients with STEMI manifested on ECG and treated by PCI were enrolled between April 1, 2018, and March 31, 2019, at our cardiologic center. Our study sought to determine the risk of death after acute myocardial infarction with carefully selected factors and parameters such as the presence of cardiogenic shock, ischemic time, left ventricular ejection fraction (LVEF), post-PCI TIMI (thrombolysis in myocardial infarction) flow and serum levels of cardio-specific markers, namely troponin T, creatine kinase and N-terminal pro-brain natriuretic peptide (NT-proBNP). Further evaluation included in-hospital, 30-day and 1-year mortality rates in shock and non-shock patients and determination of factors that influence the survival separately in each subgroup. The follow-up was carried out for 12 months after the myocardial infarction in form of outpatient examinations. After 12 months of follow-up, the collected data were statistically evaluated. RESULTS: Shock and non-shock patients differed in mortality and several other parameters including NT-proBNP values, ischemic time, TIMI flow defect and LVEF. In all outcomes (in-hospital, 30-day and 1-year mortality rates) the shock patients did worse than non-shock patients (p < 0.001). In addition, age, gender, LVEF, NT-proBNP and post-PCI TIMI flow less than 3 were found to be important factors influencing the overall survival. In shock patients, the survival was associated with age, LVEF and TIMI flow, while in non -shock patients, the factors predicting survival were age, LVEF, level of NT-proBNP and troponin levels. CONCLUSION: Shock patients differed in terms of mortality in post-PCI TIMI flow, while non-shock patients varied in troponin and NT-proBNP levels. Despite early intervention, certain risk factors might affect the clinical outcome and prognosis of patients with STEMI treated by PCI (Tab. 5, Fig. 1, Ref. 30).

Návaznosti

MUNI/A/1410/2022, interní kód MU

Název: Nové trendy v diagnostice a managementu srdečních onemocnění

Investor: Masarykova univerzita, Nové trendy v diagnostice a managementu srdečních onemocnění

Citovat

KOMOROVÁ, Zuzana, Jan MÁCHAL, Ladislav GROCH, Lenka ŠPINAROVÁ a Karel LÁBR. Effect of selected cardiovascular factors on mortality in patients with ST-segment elevation myocardial infarction treated with primary coronary intervention. BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY. BRATISLAVA: AEPRESS SRO, 2023, roč. 124, č. 6, s. 421-426. ISSN 0006-9248. Dostupné z: https://dx.doi.org/10.4149/BLL_2023_064.

@article{2281879,
   author = {Komorová, Zuzana and Máchal, Jan and Groch, Ladislav and Špinarová, Lenka and Lábr, Karel},
   article_location = {BRATISLAVA},
   article_number = {6},
   doi = {http://dx.doi.org/10.4149/BLL_2023_064},
   keywords = {myocardial infarction; pimary coronary intervention; shock; mortality; cardio-specific markers},
   language = {eng},
   issn = {0006-9248},
   journal = {BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY},
   title = {Effect of selected cardiovascular factors on mortality in patients with ST-segment elevation myocardial infarction treated with primary coronary intervention.},
   url = {http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=8003&category_id=187&option=com_virtuemart&vmcchk=1&Itemid=1},
   volume = {124},
   year = {2023}
}

TY  - JOUR
ID  - 2281879
AU  - Komorová, Zuzana - Máchal, Jan - Groch, Ladislav - Špinarová, Lenka - Lábr, Karel
PY  - 2023
TI  - Effect of selected cardiovascular factors on mortality in patients with ST-segment elevation myocardial infarction treated with primary coronary intervention.
JF  - BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
VL  - 124
IS  - 6
SP  - 421-426
EP  - 421-426
PB  - AEPRESS SRO
SN  - 00069248
KW  - myocardial infarction
KW  - pimary coronary intervention
KW  - shock
KW  - mortality
KW  - cardio-specific markers
UR  - http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=8003&category_id=187&option=com_virtuemart&vmcchk=1&Itemid=1
N2  - OBJECTIVE: This work was aimed at analyzing in-hospital, 30-day and 1-year mortality rates, impact of selected cardiovascular factors on mortality of patients with ST-segment elevation myocardial infarction (STEMI) manifested on electrocardiogram (ECG) and treated by the percutaneous coronary intervention (PCI) at our cardiac center, comparing the subgroup of non-shock (survivors and deceased) patients after STEMI and evaluating how these patients differ from each other. METHODS: In total, 270 patients with STEMI manifested on ECG and treated by PCI were enrolled between April 1, 2018, and March 31, 2019, at our cardiologic center. Our study sought to determine the risk of death after acute myocardial infarction with carefully selected factors and parameters such as the presence of cardiogenic shock, ischemic time, left ventricular ejection fraction (LVEF), post-PCI TIMI (thrombolysis in myocardial infarction) flow and serum levels of cardio-specific markers, namely troponin T, creatine kinase and N-terminal pro-brain natriuretic peptide (NT-proBNP). Further evaluation included in-hospital, 30-day and 1-year mortality rates in shock and non-shock patients and determination of factors that influence the survival separately in each subgroup. The follow-up was carried out for 12 months after the myocardial infarction in form of outpatient examinations. After 12 months of follow-up, the collected data were statistically evaluated. RESULTS: Shock and non-shock patients differed in mortality and several other parameters including NT-proBNP values, ischemic time, TIMI flow defect and LVEF. In all outcomes (in-hospital, 30-day and 1-year mortality rates) the shock patients did worse than non-shock patients (p < 0.001). In addition, age, gender, LVEF, NT-proBNP and post-PCI TIMI flow less than 3 were found to be important factors influencing the overall survival. In shock patients, the survival was associated with age, LVEF and TIMI flow, while in non -shock patients, the factors predicting survival were age, LVEF, level of NT-proBNP and troponin levels. CONCLUSION: Shock patients differed in terms of mortality in post-PCI TIMI flow, while non-shock patients varied in troponin and NT-proBNP levels. Despite early intervention, certain risk factors might affect the clinical outcome and prognosis of patients with STEMI treated by PCI (Tab. 5, Fig. 1, Ref. 30).
ER  -

KOMOROVÁ, Zuzana, Jan MÁCHAL, Ladislav GROCH, Lenka ŠPINAROVÁ a Karel LÁBR. Effect of selected cardiovascular factors on mortality in patients with ST-segment elevation myocardial infarction treated with primary coronary intervention. \textit{BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY}. BRATISLAVA: AEPRESS SRO, 2023, roč.~124, č.~6, s.~421-426. ISSN~0006-9248. Dostupné z: https://dx.doi.org/10.4149/BLL\_{}2023\_{}064.

Podrobný výpis o publikaci