The bisphenol S contamination level observed in human
follicular fluid affects the development of porcine oocytes

J 2023

The bisphenol S contamination level observed in human follicular fluid affects the development of porcine oocytes

ŽALMANOVÁ, Tereza, Kristýna HOŠKOVÁ, Šárka PROKEŠOVÁ, Jan NEVORAL, Michal JEŠETA et. al.

Basic information

Original name

The bisphenol S contamination level observed in human follicular fluid affects the development of porcine oocytes

Authors

ŽALMANOVÁ, Tereza (203 Czech Republic, guarantor), Kristýna HOŠKOVÁ (203 Czech Republic), Šárka PROKEŠOVÁ (203 Czech Republic), Jan NEVORAL (203 Czech Republic), Michal JEŠETA (203 Czech Republic, belonging to the institution), Michal BENC, Yi YOUNG-JOO, Jiří MORAVEC (203 Czech Republic), Beáta MOČÁRYOVÁ (203 Czech Republic), Stanislava MARTÍNKOVÁ (203 Czech Republic), Josef FONTANA (203 Czech Republic), Moustafa ELKALAF (203 Czech Republic), Jan TRNKA (203 Czech Republic), Jana ŽÁKOVÁ (203 Czech Republic, belonging to the institution) and Jaroslav PETR (203 Czech Republic)

Edition

Frontiers in Cell and Developmental Biology, FRONTIERS MEDIA SA, LAUSANNE, 2023, 2296-634X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30214 Obstetrics and gynaecology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.500 in 2022

RIV identification code

RIV/00216224:14110/23:00130788

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3389/fcell.2023.1145182

UT WoS

000975622600001

Keywords in English

bisphenol S (BPS); oocyte; aneuploidy; meiosis; follicular fluid (FF); endocrine disruption; embryonic development

Abstract

V originále

Bisphenol S (BPS), the main replacement for bisphenol A (BPA), is thought to be toxic, but limited information is available on the effects of Bisphenol S on ovarian follicles. In our study, we demonstrated the presence of Bisphenol S in the follicular fluid of women at a concentration of 22.4 nM. The effect of such concentrations of Bisphenol S on oocyte maturation and subsequent embryo development is still unknown. Therefore, we focused on the effect of Bisphenol S on in vitro oocyte maturation, fertilization, and embryo development. As a model, we used porcine oocytes, which show many physiological similarities to human oocytes. Oocytes were exposed to Bisphenol S concentrations similar to those detected in female patients in the ART clinic. We found a decreased ability of oocytes to successfully complete meiotic maturation. Mature oocytes showed an increased frequency of meiotic spindle abnormalities and chromosome misalignment. Alarming associations of oocyte Bisphenol S exposure with the occurrence of aneuploidy and changes in the distribution of mitochondria and mitochondrial proteins were demonstrated for the first time. However, the number and quality of blastocysts derived from oocytes that successfully completed meiotic maturation under the influence of Bisphenol S was not affected.

Citovat

ŽALMANOVÁ, Tereza, Kristýna HOŠKOVÁ, Šárka PROKEŠOVÁ, Jan NEVORAL, Michal JEŠETA, Michal BENC, Yi YOUNG-JOO, Jiří MORAVEC, Beáta MOČÁRYOVÁ, Stanislava MARTÍNKOVÁ, Josef FONTANA, Moustafa ELKALAF, Jan TRNKA, Jana ŽÁKOVÁ and Jaroslav PETR. The bisphenol S contamination level observed in human follicular fluid affects the development of porcine oocytes. Frontiers in Cell and Developmental Biology. FRONTIERS MEDIA SA: LAUSANNE, 2023, vol. 11, April 2023, p. 1-12. ISSN 2296-634X. Available from: https://dx.doi.org/10.3389/fcell.2023.1145182.

@article{2283139,
   author = {Žalmanová, Tereza and Hošková, Kristýna and Prokešová, Šárka and Nevoral, Jan and Ješeta, Michal and Benc, Michal and YoungandJoo, Yi and Moravec, Jiří and Močáryová, Beáta and Martínková, Stanislava and Fontana, Josef and Elkalaf, Moustafa and Trnka, Jan and Žáková, Jana and Petr, Jaroslav},
   article_location = {FRONTIERS MEDIA SA},
   article_number = {April 2023},
   doi = {http://dx.doi.org/10.3389/fcell.2023.1145182},
   keywords = {bisphenol S (BPS); oocyte; aneuploidy; meiosis; follicular fluid (FF); endocrine disruption; embryonic development},
   language = {eng},
   issn = {2296-634X},
   journal = {Frontiers in Cell and Developmental Biology},
   title = {The bisphenol S contamination level observed in human follicular fluid affects the development of porcine oocytes},
   url = {https://www.frontiersin.org/articles/10.3389/fcell.2023.1145182/full},
   volume = {11},
   year = {2023}
}

TY  - JOUR
ID  - 2283139
AU  - Žalmanová, Tereza - Hošková, Kristýna - Prokešová, Šárka - Nevoral, Jan - Ješeta, Michal - Benc, Michal - Young-Joo, Yi - Moravec, Jiří - Močáryová, Beáta - Martínková, Stanislava - Fontana, Josef - Elkalaf, Moustafa - Trnka, Jan - Žáková, Jana - Petr, Jaroslav
PY  - 2023
TI  - The bisphenol S contamination level observed in human follicular fluid affects the development of porcine oocytes
JF  - Frontiers in Cell and Developmental Biology
VL  - 11
IS  - April 2023
SP  - 1-12
EP  - 1-12
PB  - LAUSANNE
SN  - 2296634X
KW  - bisphenol S (BPS)
KW  - oocyte
KW  - aneuploidy
KW  - meiosis
KW  - follicular fluid (FF)
KW  - endocrine disruption
KW  - embryonic development
UR  - https://www.frontiersin.org/articles/10.3389/fcell.2023.1145182/full
N2  - Bisphenol S (BPS), the main replacement for bisphenol A (BPA), is thought to be toxic, but limited information is available on the effects of Bisphenol S on ovarian follicles. In our study, we demonstrated the presence of Bisphenol S in the follicular fluid of women at a concentration of 22.4 nM. The effect of such concentrations of Bisphenol S on oocyte maturation and subsequent embryo development is still unknown. Therefore, we focused on the effect of Bisphenol S on in vitro oocyte maturation, fertilization, and embryo development. As a model, we used porcine oocytes, which show many physiological similarities to human oocytes. Oocytes were exposed to Bisphenol S concentrations similar to those detected in female patients in the ART clinic. We found a decreased ability of oocytes to successfully complete meiotic maturation. Mature oocytes showed an increased frequency of meiotic spindle abnormalities and chromosome misalignment. Alarming associations of oocyte Bisphenol S exposure with the occurrence of aneuploidy and changes in the distribution of mitochondria and mitochondrial proteins were demonstrated for the first time. However, the number and quality of blastocysts derived from oocytes that successfully completed meiotic maturation under the influence of Bisphenol S was not affected.
ER  -

ŽALMANOVÁ, Tereza, Kristýna HOŠKOVÁ, Šárka PROKEŠOVÁ, Jan NEVORAL, Michal JEŠETA, Michal BENC, Yi YOUNG-JOO, Jiří MORAVEC, Beáta MOČÁRYOVÁ, Stanislava MARTÍNKOVÁ, Josef FONTANA, Moustafa ELKALAF, Jan TRNKA, Jana ŽÁKOVÁ and Jaroslav PETR. The bisphenol S contamination level observed in human follicular fluid affects the development of porcine oocytes. \textit{Frontiers in Cell and Developmental Biology}. FRONTIERS MEDIA SA: LAUSANNE, 2023, vol.~11, April 2023, p.~1-12. ISSN~2296-634X. Available from: https://dx.doi.org/10.3389/fcell.2023.1145182.

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