Další formáty:
BibTeX
LaTeX
RIS
@article{2291625,
author = {Chrastina, Jan and Horák, Ondřej and Ryzí, Michal and Brázdil, Milan and Novák, Zdeněk and Zeman, Tomáš and Danhofer, Pavlína},
article_location = {NEW YORK},
article_number = {11},
doi = {http://dx.doi.org/10.1007/s00381-023-05992-3},
keywords = {Seizure; Stimulation treatment; Stimulation responder; Palliative surgery},
language = {eng},
issn = {0256-7040},
journal = {Childs nervous system},
title = {Single-center long-term results of vagus nerve stimulation for pediatric epilepsy: a 10-17-year follow-up study},
url = {https://link.springer.com/article/10.1007/s00381-023-05992-3},
volume = {39},
year = {2023}
}
TY - JOUR
ID - 2291625
AU - Chrastina, Jan - Horák, Ondřej - Ryzí, Michal - Brázdil, Milan - Novák, Zdeněk - Zeman, Tomáš - Danhofer, Pavlína
PY - 2023
TI - Single-center long-term results of vagus nerve stimulation for pediatric epilepsy: a 10-17-year follow-up study
JF - Childs nervous system
VL - 39
IS - 11
SP - 3215-3224
EP - 3215-3224
PB - SPRINGER
SN - 02567040
KW - Seizure
KW - Stimulation treatment
KW - Stimulation responder
KW - Palliative surgery
UR - https://link.springer.com/article/10.1007/s00381-023-05992-3
N2 - PurposeA retrospective study, based on a prospectively built database, presents the results of long-term follow-up care of pediatric vagus nerve stimulation (VNS) patients in terms of seizure outcome, surgical aspects, the potential impact of maturation, and medication changes.MethodsFrom a prospectively built database, 16 VNS patients (median age 12.0 years, range 6.0 to 16.0 years; median seizure duration 6.5 years, range 2.0 to 15.5 years) followed for at least 10 years were graded as non-responder - NR (seizure frequency reduction < 50%), responder - R (reduction >= 50% and < 80%), and 80% responder - 80R (reduction >= 80%). Data about surgical aspects (battery replacement, system complications), seizure dynamics, and medication changes were taken from the database.ResultsThe early percentages of good results (80R + R) were 43.8% (year 1), 50.0% (year 2), and 43.8% (year 3). These percentages remained stable between years 10 and 12 (50% year 10; 46.7% year 11; 50% year 12) and increased in years 16 (60%) and 17 (75%). Depleted batteries were replaced in ten patients, six of whom were either R or 80R. In the four NR, the indication for replacement was improved quality of life. Three patients had VNS explanted or switched off-one had repeated asystolia and two were NR. The effect of hormonal changes in menarche on seizure was not proven. During the study, antiseizure medication was changed in all patients.ConclusionsThe study proved the efficacy and safety of VNS in pediatric patients over an exceptionally long follow-up period. The demand for battery replacements indicates a positive treatment effect.
ER -
CHRASTINA, Jan, Ondřej HORÁK, Michal RYZÍ, Milan BRÁZDIL, Zdeněk NOVÁK, Tomáš ZEMAN a Pavlína DANHOFER. Single-center long-term results of vagus nerve stimulation for pediatric epilepsy: a 10-17-year follow-up study. \textit{Childs nervous system}. NEW YORK: SPRINGER, 2023, roč.~39, č.~11, s.~3215-3224. ISSN~0256-7040. Dostupné z: https://dx.doi.org/10.1007/s00381-023-05992-3.
|
