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@article{2291648, author = {Rychlíčková, Jitka and Kubickova, Vendula and Suk, Pavel and Urbanek, Karel}, article_location = {BASEL}, article_number = {3}, doi = {http://dx.doi.org/10.3390/antibiotics12030437}, keywords = {colistin; quantification methods; drug stability; pharmacokinetics; drug monitoring}, language = {eng}, issn = {2079-6382}, journal = {Antibiotics-Basel}, title = {Challenges of Colistin Use in ICU and Therapeutic Drug Monitoring: A Literature Review}, url = {https://www.mdpi.com/2079-6382/12/3/437}, volume = {12}, year = {2023} }
TY - JOUR ID - 2291648 AU - Rychlíčková, Jitka - Kubickova, Vendula - Suk, Pavel - Urbanek, Karel PY - 2023 TI - Challenges of Colistin Use in ICU and Therapeutic Drug Monitoring: A Literature Review JF - Antibiotics-Basel VL - 12 IS - 3 SP - 1-17 EP - 1-17 PB - MDPI SN - 20796382 KW - colistin KW - quantification methods KW - drug stability KW - pharmacokinetics KW - drug monitoring UR - https://www.mdpi.com/2079-6382/12/3/437 N2 - The emerging resistance of Gram-negative bacteria is a growing problem worldwide. Together with the financial cost, limited efficacy, and local unavailability of newer antibiotics or their combinations, it has led to the reintroduction of colistin as a therapeutic alternative. Despite its protracted development and availability on the market, there is now a complex maze of questions surrounding colistin with a more or less straightforward relationship to its safety and efficacy. This review aims to offer a way to navigate this maze. We focus on summarizing the available literature regarding the use of colistin in critically ill patients, particularly on stability, pharmacokinetics, methods for determining plasma concentrations, and therapeutic drug monitoring benefits and limitations. Based on these data, we then highlight the main gaps in the available information and help define directions for future research on this drug. The first gap is the lack of data on the stability of intravenous and nebulization solutions at clinically relevant concentrations and under external conditions corresponding to clinical practice. Furthermore, pharmacokinetic-pharmacodynamic parameters should be validated using standardized dosing, including a loading dose. Based on the pharmacokinetic data obtained, a population model for critically ill patients should be developed. Finally, the interference of colistin with extracorporeal methods should be quantified. ER -
RYCHLÍČKOVÁ, Jitka, Vendula KUBICKOVA, Pavel SUK a Karel URBANEK. Challenges of Colistin Use in ICU and Therapeutic Drug Monitoring: A Literature Review. \textit{Antibiotics-Basel}. BASEL: MDPI, 2023, roč.~12, č.~3, s.~1-17. ISSN~2079-6382. Dostupné z: https://dx.doi.org/10.3390/antibiotics12030437.
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